A Review on Recent Advances in Transdermal Drug Delivery Systems of Tamsulosin

Abstract

Tamsulosin is a highly selective α1-adrenoreceptor antagonist. It has been developed to treat signs and symptoms of benign prostatic hyperplasia. Tamsulosin is absorbed quickly and completely in intestinal mucosa and is eliminated gradually after oral administration, which might generate some side effects as postural hypotension in number of patients. Transdermal drug delivery systems were developed for prolonged tamsulosin delivery in order to control its bioavailability and minimize its side effects. Hence, the present review aims to discuss thoroughly the various transdermal drug delivery systems of tamsulosin investigated in recent years. This review also discusses the skin as a route of drug administration, technologies in transdermal drug delivery along with different techniques used in the preparation of transdermal delivery systems of tamsulosin and their effects on its release and permeation.

Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials

“…First and foremost, they allow the delivery of the active ingredient to the exact site affected by the disease. Moreover, DDSs improve the effectiveness of the drugs, reduce the severity of side effects, and allow the use of a lower dose of the substance [1,2]. Given the above, this is one of the hottest topics in modern pharmacology or materials engineering.…”