A review on recent progress in electrochemical detection of antimalarial drugs

Nate, Zondi; Gill, Atal A.S.; Chauhan, Ruchika; Karpoormath, Rajshekhar

doi:10.1016/j.rechem.2022.100494

Cited by 6 publications

(1 citation statement)

References 66 publications

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“…HPLC is accurate and specific, making it the most commonly used [2][3][4][5][6][7][8][9]. Other techniques including liquid chromatography-mass spectrometry [10][11][12], electrochemiluminescence [13], potentiometry [14], capillary electrophoresis [15], miceller chromatography [16], chemometrics [17], and spectrophotometry [18][19][20][21] are also used. But some of these techniques are timeconsuming, require extraction with organic solvents, and have complex designs that require expensive equipment or specific detectors.…”

Section: ■ Introductionmentioning

confidence: 99%

Chromatographic and Spectrophotometric Determination of Clindamycin in Pharmaceutical Products

Al-Momani,

Al-Kilani

2024

Indones. J. Chem.

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Accurate, precise, and reliable chromatographic and spectrophotometric methods were developed for determining clindamycin (CLD) in pharmaceutical formulations. The spectrophotometric method was adopted for flow injection analysis (FIA). The method is based on the online oxidation of CLD and measuring the absorbance of the resulting product using a flow cell at 605 nm. Experimental conditions, including FIA variables and reaction conditions, were optimized. The chromatographic separation was achieved using a C8 column and an isocratic mobile phase. The composition of the mobile phase selected for the analysis consists of a mixture of phosphate buffer (50%), MeOH (35%), and ACN (15%), adjusted to a pH of 3.47 by phosphoric acid. The eluent was monitored with a UV detector at 205 nm. The linearity range was 10–200 and 50–800 µg/mL for the FIA and HPLC, respectively. The applicability of the FIA and HPLC methods was validated by analyzing CLD in synthetic and commercial pharmaceutical products. No significant interferences were observed from the common excipients usually used in commercial formulations.

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