A Review on Residence Time Distribution (RTD) in Food Extruders and Study on the Potential of Neural Networks in RTD Modeling

Ganjyal, Girish M.; Hanna, Milford A.

doi:10.1111/j.1365-2621.2002.tb09491.x

Cited by 40 publications

(20 citation statements)

References 32 publications

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“…It has been reported that heat (baking) above 180°C negatively affects the TPC of the grape seed flour [15]. The difference may be attributed to the short residence time usually less than 45 S in extrusion processing [44] as opposed to significantly longer baking times. In support, recently, we found that extrusion technology has a very minimal effect on the loss of water soluble TPC in cherry pomace incorporated in cornstarch, with no significant decrease of TPC in the extruded product [18].…”

Section: Total Polyphenolic Content Of Gp Extrudates Extractsmentioning

confidence: 90%

“…Previously, the baking process of grape seed flour significantly reduced its antioxidant activity [15]. The difference in time duration of exposure to heat which is less than 45s in extrusion processing [44] can explain the retention of antioxidant activity of the GP extrudates. Based on the physicochemical quality of the extruded products with GP, the addition of 5% GP level in cornstarch processed at 16% moisture level and 150 rpm screw speed is promising to produce healthy extrudates.…”

Section: Effect Of Extrusion On the Total Antioxidant Activities Of Gmentioning

confidence: 99%

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Stability and Functionality of Grape Pomace Used as a Nutritive Additive During Extrusion Process

Bibi¹,

Rj²,

Zhang³

et al. 2017

J Food Process Technol

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Grape pomace (GP) is a major byproduct of wine and juice industry, rich in polyphenolics with demonstrated health benefits. Extrusion processing for development of healthy and quality GP supplemented cornstarch snack foods was evaluated using response surface methodology. The retainability of polyphenolic content and antioxidant activity after extrusion processing were further assessed. The processing variables were feed moisture (16, 20, and 24 ± 0.2% w.b.), screw speed (150, 200, and 250 rpm), and the level of GP supplementation (0, 5, and 10% w/w). Extrudates with 5% GP and 16 ± 0.2% feed moisture had a high overall expansion ratio of 3.83 ± 0.14, and overall low density (0.11 ± 0.00 g/cm 3 ). Total polyphenolic content (TPC) of the extrudates (5% GP, and 16% feed moisture) extruded at 150 and 250 rpm retained up to 74.1% and 78.57% respectively, while TPC was retained at 95% when extruded under 200 rpm with 10% GP and 16% feed moisture. Additionally, the total antioxidant activity and 2,2-diphenyl-1-picrylhydrazyl scavenging activity of the 5% GP extrudates retained 98% after extrusion processing. Moreover, polyphenolic extract of 5% GP extrudates suppressed reactive oxygen species in Caco-2 cells induced by hydrogen peroxide. In conclusion, GP incorporation in cornstarch extrudates improved both the physicochemical quality as well as nutritional value of products. Our study indicates that GP can be effectively incorporated into extruded foods by providing enhanced nutritional value without losing the expansion characteristics.

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Section: Total Polyphenolic Content Of Gp Extrudates Extractsmentioning

confidence: 90%

Section: Effect Of Extrusion On the Total Antioxidant Activities Of Gmentioning

confidence: 99%

Stability and Functionality of Grape Pomace Used as a Nutritive Additive During Extrusion Process

Bibi¹,

Rj²,

Zhang³

et al. 2017

J Food Process Technol

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show abstract

“…In reality, the conventional batch processes of manufacturing have several drawbacks (e.g., poor controllability, low yield, and difficult scalability) and are labor intensive [31,32]. Thus, ongoing efforts have focused on the development and optimization of continuous processes.…”

Section: And Hme Processing Technologymentioning

confidence: 99%

“…The limited flexibility, and intensive costs and time taken for drug developments are the major reasons why many industries have moved to using continuous processing approaches. Other important factors governing this move include reducing the size of the manufacturing plant and using available in-house capacity for XXXX [DE1] [30,31]. However, a revision of the manufacturing regulations related to the use of CM will prove it to be beneficial for patients and healthcare systems as a whole [34,35].…”

Section: Applications Via Hmementioning

confidence: 99%

Continuous manufacturing via hot-melt extrusion and scale up: regulatory matters

Maniruzzaman

Nokhodchi

2017

Drug Discovery Today

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A c c e p t e d M a n u s c r i p t Highlights  HME can be exploited in a broad range of applications for advanced drug delivery  Unique advantages to be utilised in a solvent free manufacturing platform  A means to explore the potential of continuous manufacture of pharmaceuticals  Scale-up issue considerations, from an FDA compliance point of view  HME regulatory guidelines for the manufacture of novel drug delivery systems Ali NokhodchiAli Nokhodchi is a professor of pharmaceutics and drug delivery at the University of Sussex. He has supervised over 120 Mpharm, PharmD, and MSc students and 15 PhD postgraduate students at several institutions in various fields of pharmaceutical formulations and drug delivery. He is an editorial board member of over 20 peer-reviewed international journals. Ali has published over 185 research articles in various fields of pharmaceutics, including tableting, particle engineering, inhalation, nanoparticles, dissolution, skin delivery, and controlled-release formulations. In addition, he has published five book chapters on skin, controlled-release formulations, particle engineering, and inhalation products. Ali has also been the editor of a book on pulmonary delivery published by Wiley in 2015. He has been the recipient of several prizes in pharmaceutical sciences and has been listed by Essential Science Indicators in the top 1% scientists in the field of pharmacology and toxicology.Currently, because globalization, the pharmaceutical industry is facing enormous challenges to comply with regulatory matters. Reduced patent life and overall decreased profitability of newly discovered drugs are also forcing the pharmaceutical industry to shorten the drug development time with maximum throughput. Therefore, continuous manufacturing (CM) processes via hot melt extrusion (HME) can be a promising alternative for achieving these goals. HME offers solvent-free green technology with a process that is easy to scale up. Moreover, CM provides better product quality assurance compared with batch processes, with fewer labor costs and shorter time to development. In this review, we primarily focus on various aspects of CM and the emerging application of HME to bridge the current manufacturing gap in pharmaceutical sphere.

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“…The analysis was made based on effects of above process variables on the parameters of the complete model. Ganjyal and Hanna (2002) reviewed the various aspects of RTD in the extrusion process and prospects of using neural network (NN) to model. Ganjyal, Hanna, and Jones (2003) predicted physical properties of waxy cross-linked starches using a NN model.…”

Section: Introductionmentioning

confidence: 99%

Modeling residence time distribution in a twin-screw extruder as a series of ideal steady-state flow reactors

Kumar

Ganjyal

Jones

et al. 2008

Journal of Food Engineering

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A Review on Residence Time Distribution (RTD) in Food Extruders and Study on the Potential of Neural Networks in RTD Modeling

Cited by 40 publications

References 32 publications

Stability and Functionality of Grape Pomace Used as a Nutritive Additive During Extrusion Process

Stability and Functionality of Grape Pomace Used as a Nutritive Additive During Extrusion Process

Continuous manufacturing via hot-melt extrusion and scale up: regulatory matters

Modeling residence time distribution in a twin-screw extruder as a series of ideal steady-state flow reactors

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