A Review on Rheology of Non-Newtonian Properties of Blood

Fatahian, Esmaeel; Kordani, Naser; Fatahian, Hossein

doi:10.31436/iiumej.v19i1.826

Cited by 13 publications

(5 citation statements)

References 41 publications

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“…Hemorheology refers to the study of blood flow and its related properties, including viscosity, deformability of blood cells (such as RBCs), and the behavior of blood under various conditions. [85] In diabetes, micro-angiopathic complications often arise due to alterations in hemorheological parameters, impacting blood flow and microcirculation in small blood vessels. [86] Diabetes can lead to increased blood viscosity, primarily due to higher levels of plasma proteins, such as fibrinogen and globulins, as well as elevated levels of lipids and hyperglycemia-induced changes in blood components.…”

Section: Hemorheological Changes On Micro-angiopathic Complications I...mentioning

confidence: 99%

Red blood cells as biomarkers and mediators in complications of diabetes mellitus: A review

Obeagu

2024

Medicine

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Red blood cells (RBCs), traditionally recognized for their oxygen transport role, have garnered increasing attention for their significance as crucial contributors to the pathophysiology of diabetes mellitus. In this comprehensive review, we elucidate the multifaceted roles of RBCs as both biomarkers and mediators in diabetes mellitus. Amidst the intricate interplay of altered metabolic pathways and the diabetic milieu, RBCs manifest distinct alterations in their structure, function, and lifespan. The chronic exposure to hyperglycemia induces oxidative stress, leading to modifications in RBC physiology and membrane integrity. These modifications, including glycation of hemoglobin (HbA1c), establish RBCs as invaluable biomarkers for assessing glycemic control over extended periods. Moreover, RBCs serve as mediators in the progression of diabetic complications. Their involvement in vascular dysfunction, hemorheological changes, and inflammatory pathways contributes significantly to diabetic microangiopathy and associated complications. Exploring the therapeutic implications, this review addresses potential interventions targeting RBC abnormalities to ameliorate diabetic complications. In conclusion, comprehending the nuanced roles of RBCs as biomarkers and mediators in diabetes mellitus offers promising avenues for enhanced diagnostic precision, therapeutic interventions, and improved patient outcomes. This review consolidates the current understanding and emphasizes the imperative need for further research to harness the full potential of RBC-related insights in the realm of diabetes mellitus.

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Section: Hemorheological Changes On Micro-angiopathic Complications I...mentioning

confidence: 99%

Red blood cells as biomarkers and mediators in complications of diabetes mellitus: A review

Obeagu

2024

Medicine

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“…This includes questions of belief in the Islamic religion. According to the rules or experts, Tauhid Science is defined as "a science that discusses all religious beliefs using convincing arguments" (Fatahian, Kordani, and Fatahian 2018). Tawhid encourages humans to master and utilize the universe because it has been subjugated to humans (QS.…”

Section: The Relationship Between Tawhid and Sciencementioning

confidence: 99%

TAWHID: As a Basis for Science Development

Anwar,

Yasin,

Yusra

et al. 2023

J. Nat. Sci. Integr

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The development of science and technology is currently so rapid and has become an inevitable need. Religion through its noble books certainly has a lot of knowledge. For this reason, it is necessary to carry out scientific integration between science and Islam, in this case Al Qur’an and Hadith. However, there are pros and cons to this view. In accordance with the establishment of UIN Suska as an Islamic University that provides education based on Islamic values, the aim of this study is to support the integration of Islam in the science learning process so that it can increase our understanding of the concept of tawhid, not reverse. The research method developed was a literature review by collecting data from various sources, both books, journals, and scientific articles. The result of this study is a literature review of tawhid as a basis for the science development. Thereby, in this case, science goes hand in hand with Islamic understanding so that it can strengthen the faith and tawhid on mankind as signs of the Oneness and glory of Allah SWT.Keywords: Tawhid, Science, Knowledge, Islam

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“…It was previously shown that the non-Newtonian nature of blood acts as a regulating factor to reduce the flow resistance and wall shear stress thereby considering shear thinning to have the most significant role in facilitating blood flow through stenotic vessels (Shukla et al, 1980). Moreover, blood is usually considered as a predominantly shear thinning fluid, especially under steady flow conditions (Fatahian et al, 2018). Thus, this property seems to have the most important non-Newtonian impact (Sochi, 2013).…”

Section: Modeling Of the Capillary Blood Flowmentioning

confidence: 99%

Application of a multicomponent model of convectional reaction-diffusion to description of glucose gradients in a neurovascular unit

Nartsissov

2022

Front. Physiol.

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A supply of glucose to a nervous tissue is fulfilled by a cerebrovascular network, and further diffusion is known to occur at both an arteriolar and a microvascular level. Despite a direct relation, a blood flow dynamic and reaction-diffusion of metabolites are usually considered separately in the mathematical models. In the present study they are coupled in a multiphysical approach which allows to evaluate the effects of capillary blood flow changes on near-vessels nutrient concentration gradients evidently. Cerebral blood flow (CBF) was described by the non-steady-state Navier-Stokes equations for a non-Newtonian fluid whose constitutive law is given by the Carreau model. A three-level organization of blood–brain barrier (BBB) is modelled by the flux dysconnectivity functions including densities and kinetic properties of glucose transporters. The velocity of a fluid flow in brain extracellular space (ECS) was estimated using Darcy’s law. The equations of reaction-diffusion with convection based on a generated flow field for continues and porous media were used to describe spatial-time gradients of glucose in the capillary lumen and brain parenchyma of a neurovascular unit (NVU), respectively. Changes in CBF were directly simulated using smoothing step-like functions altering the difference of intracapillary pressure in time. The changes of CBF cover both the decrease (on 70%) and the increase (on 50%) in a capillary flow velocity. Analyzing the dynamics of glucose gradients, it was shown that a rapid decrease of a capillary blood flow yields an enhanced level of glucose in a near-capillary nervous tissue if the contacts between astrocytes end-feet are not tight. Under the increased CBF velocities the amplitude of glucose concentration gradients is always enhanced. The introduced approach can be used for estimation of blood flow changes influence not only on glucose but also on other nutrients concentration gradients and for the modelling of distributions of their concentrations near blood vessels in other tissues as well.

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A Review on Rheology of Non-Newtonian Properties of Blood

Cited by 13 publications

References 41 publications

Red blood cells as biomarkers and mediators in complications of diabetes mellitus: A review

Red blood cells as biomarkers and mediators in complications of diabetes mellitus: A review

TAWHID: As a Basis for Science Development

Application of a multicomponent model of convectional reaction-diffusion to description of glucose gradients in a neurovascular unit

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