A Review on Role of Plant(s) Extracts and its Phytochemicals for the Management of Diabetes

Abstract

The present review focused on plant extracts or phytochemicals role in diabetes management has been tried by many researchers. I have attempted to compile a list of total 419 plant species belongs to 133 families have been used for in-vitro and in-vivo studies. The plant extract or phytochemicals have involved in decreasing or increasing or stimulating different mechanisms in reducing diabetes and they have been listed in tabular form. By this review, few molecules are used in diabetes management and they possess molecular mechanisms or involved in signal transduction to initiate the insulin production or utilization of blood glucose level bring down to normal stage. The researchers have used different parts of the plant extracts or individual phytochemicalsfor antidiabetic activities. This review brings the researcher data on antidiabetic activities of different plant extracts role in reducing of diabetic problems.

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“…into various products or limiting the production of byproducts. Some of the extracts have gone about as insulin like action or prompt the activity of insulin, and some hindered the activity of enzymes, viz., α-amylase, α-glucosidase (Govindappa, 2015). Streptozotocin is notable for its particular pancreatic islet β-cell cytotoxicity and has been broadly utilized to incite diabetes mellitus in animals.…”

Review on Phaleria macrocarpa Pharmacological and Phytochemical Properties

“…These compounds play an important role in growth and reproduction, providing protection against pathogens, and predators [37]. Phenolic compounds exhibit a wide range of physiological properties, such as anti-allergenic, anti-artherogenic, antiinflammatory, anti-microbial, antioxidant, anti-thrombotic, cardioprotective and vasodilator effects [2,9,14,22,23].…”

“…This plant belongs to Thymelaeaceae family and has been mostly used traditionally as an indispensable medicinal plant in Malaysia and Indonesia [1]. Several ailments such as cancer, impotence, haemorrhoids, Diabetes mellitus, allergies, liver and heart diseases, kidney disorders, blood diseases, rheumatism, high blood pressure, stroke, migraine, skin diseases, and acne has been treated with this plant [2][3][4].…”

“…The stems has been used in treating bone cancer [8]; the leaves has been used for impotence, blood diseases, allergies, diabetes mellitus and tumor treatments [2,9]; the egg shell of seeds has been used for breast cancer, cervix cancer, lung diseases, liver and heart diseases treatments [10]; and the fruits consisting of alkaloid, saponin, flavonoid and polyphenol has been used as antioxidants [11]. The use of this plant in traditional medicine has been documented in literatures.…”

“…Compounds such as kaempferol-3-O-β-D-glucoside [4], gallic acid [18], 29-norcucurbitacin, fevicordin A and fevicordin A glucosides [19], and Cucurbitacins have anticancer effects on cancer cells [20,21]. Some of these compounds exhibit a wide range of physiological properties, such as anti-allergenic, anti-artherogenic, antiinflammatory, anti-microbial, antioxidant, anti-thrombotic, cardioprotective and vasodilator effects [2,9,14,22,23].…”