A Review on Saponin Biosynthesis and its Transcriptomic Resources in Medicinal Plants

Kavya, N. M.; Lateef, Adil; Palanisamy, S.

doi:10.1007/s11105-021-01293-8

Cited by 18 publications

(10 citation statements)

References 71 publications

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“…These results are in agreement with previous reports [1,3,37]. The antibacterial activity of the plant could be due to the presence of saponins [38,39], with active compounds such as hederacoside C in particular [40,41]. While the extract showed a significant antibacterial activity against a variety of tested bacteria, this sample only had a negligible amount of antibacterial activity against the test bacteria, as determined by their MIC values.…”

Section: Antibacterial Activitysupporting

confidence: 92%

Optimization of Subcritical Fluid Extraction for Total Saponins from Hedera nepalensis Leaves Using Response Surface Methodology and Evaluation of Its Potential Antimicrobial Activity

Duong

Linh

et al. 2022

Processes

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(1) Background: Hedera nepalensis (Araliaceae) is a recognized medicinal plant founded in Asia that has been reported to work in antioxidant, antifungal, antimicrobial, and antitumor capacities. (2) Methods: The subcritical fluid extraction of saponin from Hedera nepalensis leaves and the optimum of the extraction process based on yield of saponin contents (by calculating the hederacoside C contents in dried Hedera nepalensis leaves) are examined by response surface methodology (RSM). Furthermore, the antimicrobial activity of the extract is tested for potential drug applications in the future. (3) Results: Based upon RSM data, the following parameters are optimal: extraction time of 3 min, extraction temperature of 150 °C, and a sample/solvent ratio of 1:55 g/mL. Under such circumstances, the achieved yield of saponin is 1.879%. Moreover, the extracts inhibit the growth of some bacterial strains (Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenza) at a moderate to strong level with inhibition zone diameter values ranging from 12.63 to 19.50 mm. (4) Conclusions: The development of such a model provides a robust experimental process for optimizing the extraction factors of saponin contents from Hedera nepalensis extract using subcritical fluid extraction and RSM. Moreover, the current work reveals that saponin extracts of Hedera nepalensis leaves exhibit a potential antimicrobial activity, which can be used as scientific evidence for further study.

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Section: Antibacterial Activitysupporting

confidence: 92%

Optimization of Subcritical Fluid Extraction for Total Saponins from Hedera nepalensis Leaves Using Response Surface Methodology and Evaluation of Its Potential Antimicrobial Activity

Duong

Linh

et al. 2022

Processes

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“…Saponins, as a class of widely distributed natural compounds with various biological activities, have been found in more than 100 families of plants and a few marine organisms, such as Theaceae , Asparagaceae , Liliaceae , Agavaceae , Solanaceae , Alliaceae , Poaceae and starfish, etc. [ 13 , 20 , 21 , 22 , 23 ]. The tea seeds and flowers are rich in triterpene saponins, and their chemical structures and some bioactivities have been reviewed [ 8 , 9 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…The data showed that the secondary metabolism in different organs was remarkably diverse ( Figure 2 ), and two modules containing 1383 DEGs were found to be positively correlated with saponin content ( Figure 3 ). MVA and MEP are two classic pathways involved in the biosynthesis of plant triterpene saponins [ 13 ]. In this work, several key enzyme genes in the MVA pathway were highly expressed in both the seeds and flowers compared with leaves, especially HMGS , MVD and IDI , which were significantly correlated with the saponin content ( Figure 4 ).…”

Section: Discussionmentioning

confidence: 99%

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Comparative Transcriptome and Phytochemical Analysis Provides Insight into Triterpene Saponin Biosynthesis in Seeds and Flowers of the Tea Plant (Camellia sinensis)

et al. 2022

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Triterpene saponins exhibit various biological and pharmacological activities. However, the knowledge on saponin biosynthesis in tea plants (Camellia sinensis L.) is still limited. In this work, tea flower and seed samples at different developmental stages and leaves were collected and analyzed with UPLC-PDA-MS and RNA sequencing for saponin determination and transcriptome comparison. The saponin content reached around 19% in the freshly mature seeds and 7% in the green flower buds, and decreased with the fruit ripeness and flower blooming. Almost no saponins were detected in leaf samples. PCA and KEGG analysis suggested that the gene expression pattern and secondary metabolism in TF1 and TS2 vs. leaf samples were significantly different. Weighted gene coexpression network analysis (WGCNA) uncovered two modules related to saponin content. The mevalonate (MVA) instead of 2-C-methyl-d-erythritol-4-phospate (MEP) pathway was responsible for saponin accumulation in tea plants, and 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS), diphosphomevalonate decarboxylase (MVD) and isopentenyl diphosphate isomerase (IDI) may be the key enzymes involved in saponin biosynthesis in tea seeds and flowers. Moreover, ten transcription factors (TFs) were predicted to regulate saponin biosynthesis in the tea plant. Taken together, our study provides a global insight into the saponin biosynthesis and accumulation in the tea plant.

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“…Modern biotechnological applications include the development of morphological and molecular markers such as RAPD, RFLP, and ISSR, as well as biodiversity assessment (Niazian, 2019). DNA microarrays in medicinal plants have emerged as a promising tool for comparing gene expression patterns under different growing conditions (Kavya et al, 2021). Rapid and low-cost NGS technology can now discover sequences and genotype thousands of markers across any gene of interest in a single step.…”

Section: Deploying Biotechnology Based Breeding Program and Genetic T...mentioning

confidence: 99%

A Review on the Comprehensive Phylogenetic Relationship among Indian Species of Drimia: An Ethno-medicinal Indigenous Crop from Tribal Forest Belt

Shit¹,

Kumar²

2023

Preprint

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Indian Tribal population is known for their self-sustainability, including their robust natural health and trivial lifestyle, further traditionally relied on medicinal plants throughout history. The evolutionary history of the ethnic-medicinal bulbous geophyte has long been a contention in monocot systematics. In India, the genus is represented by a species array. Moreover, the phylogeny delimitation amongst them is poorly defined to date. Phenolics, sterols, proteins and some other phytochemicals of Drimia have also been isolated for pharmacological and clinical studies that have strongly recommended their background effect of geographical positioning. Through several in vivo and in vitro studies, extracts derived from Drimia species demonstrated biological activity, including antifungal antibacterial, antiviral, anti-inflammatory antioxidant, and insecticidal properties. This review highlights the comprehensive phylogenetic analysis of Indian spp. of Drimia and the multi-omics-based approach for species delineation, the discovery of candidate genes and the development of plant-based drugs, as well as the long-term utilisation of plant pharmaceutical resources.

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A Review on Saponin Biosynthesis and its Transcriptomic Resources in Medicinal Plants

Cited by 18 publications

References 71 publications

Optimization of Subcritical Fluid Extraction for Total Saponins from Hedera nepalensis Leaves Using Response Surface Methodology and Evaluation of Its Potential Antimicrobial Activity

Optimization of Subcritical Fluid Extraction for Total Saponins from Hedera nepalensis Leaves Using Response Surface Methodology and Evaluation of Its Potential Antimicrobial Activity

Comparative Transcriptome and Phytochemical Analysis Provides Insight into Triterpene Saponin Biosynthesis in Seeds and Flowers of the Tea Plant (Camellia sinensis)

A Review on the Comprehensive Phylogenetic Relationship among Indian Species of Drimia: An Ethno-medicinal Indigenous Crop from Tribal Forest Belt

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