A review on strategies for decreasing E. coli O157:H7 risk in animals

Saeedi, Pouya; Yazdanparast, Maryam; Behzadi, Elham; Salmanian, Ali Hatef; Mousavi, Seyed Latif; Nazarian, Javad; Amani, Jafar

doi:10.1016/j.micpath.2017.01.001

Cited by 68 publications

(56 citation statements)

References 89 publications

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“…In a commercial feedlot, the SRP vaccine demonstrated 53% efficacy in reducing O157 prevalence and 73% efficacy in reducing prevalence of high shedders among cattle (Cull et al, 2012). Overall, these studies support cattle vaccination can effectively reduce STEC shedding (Varela et al, 2013) and researchers are experimentally evaluating new formulations that may improve efficacy or provide alternatives to existing vaccines (Martorelli et al, 2017;Saeedi, Yazdanparast, & Behzadi, 2017;Schmidt et al, 2018).…”

Section: Vaccinesmentioning

confidence: 76%

“…In a commercial feedlot, the SRP vaccine demonstrated 53% efficacy in reducing O157 prevalence and 73% efficacy in reducing prevalence of high shedders among cattle (Cull et al, ). Overall, these studies support cattle vaccination can effectively reduce STEC shedding (Varela et al, ) and researchers are experimentally evaluating new formulations that may improve efficacy or provide alternatives to existing vaccines (Martorelli et al, ; Saeedi, Yazdanparast, & Behzadi, ; Schmidt et al, ). However, farmers in the United States and Canada have shown little interest in vaccinating their cattle against bacteria that cause no disease in these animals without any incentives or regulatory mandates (Matthews et al, ; Smith, ).…”

Section: Control Strategies Targeting Stec Can Also Mitigate Ar‐stecmentioning

confidence: 83%

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Antibiotic‐resistant Shiga toxin‐producing Escherichia coli: An overview of prevalence and intervention strategies

Mir

Kudva

2018

Zoonoses and Public Health

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Shiga toxin‐producing Escherichia coli (STEC) are foodborne pathogens that can cause severe diseases, including bloody diarrhoea and kidney failure, in humans, while remaining harmless to its primary reservoir hosts, cattle. Antibiotics such as azithromycin, fosfomycin and meropenem are being used and recommended in the treatment of early‐stage STEC (mainly E. coli O157:H7) infections, as these are reportedly effective in preventing Shiga toxin release and kidney failure while eliminating the pathogen. However, antibiotic resistance among STEC isolates could negatively impact these and other similar treatment options while contributing towards the spread of antibiotic resistance genes especially if encoded on mobile genetic elements like plasmids. Antibiotic resistance among STEC isolates recovered from animals and patients is being reported globally. A comprehensive understanding of the prevalence of antibiotic‐resistant STEC (AR‐STEC) and the mechanisms promoting this resistance among these bacteria could help direct therapies and develop strategies to effectively reduce/eliminate these pathogens. Here, we have reviewed literature from the past three decades to gain insights on this prevalence and its impact on human infections. In addition, we have reviewed various strategies proposed by researchers to control STEC that in turn would be applicable to AR‐STEC as well.

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Section: Vaccinesmentioning

confidence: 76%

“…In a commercial feedlot, the SRP vaccine demonstrated 53% efficacy in reducing O157 prevalence and 73% efficacy in reducing prevalence of high shedders among cattle (Cull et al, ). Overall, these studies support cattle vaccination can effectively reduce STEC shedding (Varela et al, ) and researchers are experimentally evaluating new formulations that may improve efficacy or provide alternatives to existing vaccines (Martorelli et al, ; Saeedi, Yazdanparast, & Behzadi, ; Schmidt et al, ). However, farmers in the United States and Canada have shown little interest in vaccinating their cattle against bacteria that cause no disease in these animals without any incentives or regulatory mandates (Matthews et al, ; Smith, ).…”

Section: Control Strategies Targeting Stec Can Also Mitigate Ar‐stecmentioning

confidence: 83%

Antibiotic‐resistant Shiga toxin‐producing Escherichia coli: An overview of prevalence and intervention strategies

Mir

Kudva

2018

Zoonoses and Public Health

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“…E. coli O157:H7, which exhibits optimum growth at pH 7.0, can grow in acidic foods, including under certain food processing conditions and in the human gastrointestinal tract (Saeedi et al, 2017;Samelis et al, 2004;Tosun & Gönül, 2006). This pathogen has a high acid tolerance and can survive exposure to pH 3.0 and 2.5 (adjusted with HCl) for at least 4 hr at 37 C (Benjamin & Datta, 1995;Molina, Parma, & Sanz, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Intimin, a product of the eae gene, is essential for adherence of the microorganism to the intestinal epithelium, that is, attaching and effacing lesions. Additionally, a plasmid-encoded hemolysin (hly) induces extraintestinal lesions and enterocyte and leukocyte lysis (Azizoglu & Drake, 2007;Saeedi et al, 2017). Environmental stresses, such as pH, temperature, and pressure, may not only affect the survival of E. coli O157:H7 but also modulate the expression of virulence genes (Carey, Kostrzynska, & Thompson, 2009;Elhanafi, Leenanon, Bang, & Drake, 2004;Leenanon, Elhanafi, & Drake, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of lactic acid stress with lactic acid adaptation on the survival and expression of virulence‐related genes in Escherichia coli O157:H7

et al. 2019

Journal of Food Safety

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This study was aimed to investigate the effects of lactic acid stress with acid adaptation on the survival and expression of virulence‐related genes in Escherichia coli O157:H7 (strains CICC21530, 89, 95, 112, 109, and J42). E. coli were subjected to acid adaption (pH 5.0) for 1–4 hr and then exposed to acid stress (pH 3.5) for 30–120 min. Results showed that exposure to pH 3.5 decreased the survival of E. coli strains, in which strains 109, 112, and J42 had stronger acid resistance. The expression of virulence‐related genes of most strains decreased after exposure to pH 3.5 compared with nonstressed cells. In addition, acid adaptation increased the acid resistance of most strains, except for CICC21530 and J42. And the virulence expression of most acid‐adapted cells decreased or showed no significant changes compared with nonadapted cells. There were no obvious relationships between the survival and expression of virulence‐related genes in E. coli O157:H7 strains. However, variable acid resistance of acid‐adapted strains was existed, and some acid adaptation increased the strain survival and expression of virulence‐related genes, which may still threaten food safety. Practical Applications This study evaluated the effects of lactic acid stress with acid adaptation on the survival and expression of virulence‐related genes in Escherichia coli O157:H7. Acid adaptation could enhance the survival and virulence expression of some strains, which will threaten the safety of acidic food during processing and storage. Furthermore, variable acid resistance of acid‐adapted strains should be noticed in surveillance and control of E. coli O157:H7 in environment and food, which is beneficial for its scientific and effective risk assessment and control.

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“…Shiga toxin-producing Escherichia coli (STEC) are a class of E. coli responsible for many food-borne outbreaks and sporadic cases of gastrointestinal illness, with a range of symptoms including haemorrhagic colitis (stomach cramping and bloody diarrhoea) and the potentially fatal hemolytic-uremic syndrome (break down of red blood cells, kidney failure, reduction in platelet cells) [6]. In the United States alone, STEC strains are estimated to cause approximately 176,000 illnesses, 2,400 hospitalizations, and 20 deaths each year [7].…”

Section: Introductionmentioning

confidence: 99%

Development and on-site evaluation of an easy-to-perform and low-cost food pathogen diagnostic workflow for low-resource communities

Mason

Botella

2020

Preprint

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20Food-borne diseases are a leading cause of illness and death in many developing 21 countries and thus, there is a real need to develop affordable and practical 22 technologies that can help improve food safety in these countries. The ability to 23 efficiently identify food pathogens is essential to allow national regulatory authorities 24 to monitor food quality and implement safety protocols. In this study, we have 25 developed a simple, low-cost ($0.76 (USD)) complete food pathogen diagnostic 26 workflow ideally suited for deployment in low-resource environments that uses a 27 simple four step process (sample enrichment, cell lysis, DNA amplification, and 28 naked-eye readout). The minimal number of steps and equipment involved in our 29 diagnostic workflow, as well as the simplicity of the yes/no flocculation readout, 30 allows non-technical personnel to perform and interpret the assay. To evaluate the 31 system's performance, we tested the entire system on fresh produce samples 32 collected from local farms and markets in Cambodia for the presence of the E. coli 33 O157 O-antigen polymerase, wzy. Although this was a proof-of-concept study, our 34 system successfully revealed a clear correlation between the origin and condition of 35 the produce collected and their likelihood of contamination. In conclusion, we believe 36 that our easy-to-perform diagnostic system can have a significant impact on 37 improving food quality and human health if adopted by regulatory authorities in 38 developing countries due to the assay's simplicity, affordability, and adaptability. 3 40 Introduction 41Over the last 20 years, there has been a significant increase in the incidence of food-42 borne diseases worldwide [1]. The risk of infection by a food-borne disease is 43 significantly higher in developing countries due to a combination of factors including 44 access to clean water and bathroom facilities, poor hygiene education, inadequate 45 food production and storage practices, and either insufficient food safety legislation 46 or poor implementation of existing legislation [2]. Most food-borne disease infections 47 in these countries result from the consumption of perishable foods sold in informal 48 markets [3] and, as such, food-borne diseases have become a leading cause of 49 illness and death in developing countries [4, 5]. Hence, there is a need for low-cost 50 and simple technologies that can help health authorities to monitor and enforce 51 adequate levels of food safety. In addition to the health benefits, increased food 52 safety standards would likely have economic benefits as a result of increased 53 demand for fresh produce exports [3]. 54 55 Shiga toxin-producing Escherichia coli (STEC) are a class of E. coli responsible for 56 many food-borne outbreaks and sporadic cases of gastrointestinal illness, with a 57 range of symptoms including haemorrhagic colitis (stomach cramping and bloody 58 diarrhoea) and the potentially fatal hemolytic-uremic syndrome (break down of red 59 blood cells, kidney failure, re...

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A review on strategies for decreasing E. coli O157:H7 risk in animals

Cited by 68 publications

References 89 publications

Antibiotic‐resistant Shiga toxin‐producing Escherichia coli: An overview of prevalence and intervention strategies

Antibiotic‐resistant Shiga toxin‐producing Escherichia coli: An overview of prevalence and intervention strategies

Effects of lactic acid stress with lactic acid adaptation on the survival and expression of virulence‐related genes in Escherichia coli O157:H7

Development and on-site evaluation of an easy-to-perform and low-cost food pathogen diagnostic workflow for low-resource communities

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