A review on synthesis, properties and applications of natural polymer based carrageenan blends and composites

Zia, Khalid Mahmood; Tabasum, Shazia; Nasif, Muhammad; Sultan, Neelam; Aslam, Nosheen; Noreen, Aqdas; Zuber, Mohammad

doi:10.1016/j.ijbiomac.2016.11.095

Cited by 368 publications

(150 citation statements)

References 282 publications

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“…Comparing MET:CS and MET:CAR wafers, it was demonstrated that MET:CAR formulations were stronger and more resistant to compressive deformation than MET:CS wafers due to the functional and physical properties of CAR which possess stabilizing, gelling and thickening ability (Pairatwachapun, et al, 2016). Due to the high robustness, good compatibility and persistent viscoelasticity, CAR has also been used in tablets as excipient for sustained release formulations (Zia, et al, 2017) due to its ability produce stronger formulations. On the other hand, MET:CS formulations were weaker and brittle due to highly water soluble nature of soluble CS and therefore unable to swell to form stable gels.…”

Section: Mechanical Properties Of the Wafersmentioning

confidence: 99%

Development and functional characterization of composite freeze dried wafers for potential delivery of low dose aspirin for elderly people with dysphagia

Farias

Boateng

2018

International Journal of Pharmaceutics

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The impact of demographic ageing is likely to be of major significance in the coming decades due to low birth rates and higher life expectancy. Older people generally require more prescribed medicines due to the presence of multiple conditions such as dysphagia which can make swallowing medicines challenging. This study involves the development, characterization and optimization of composite wafers for potential oral and buccal delivery of low dose aspirin to prevent thrombosis in elderly patients with dysphagia. Blank (BLK) wafers (no loaded drug) were initially formulated by dissolving combinations of metolose (MET) with carrageenan (CAR) and MET with low molecular weight chitosan (CS) in different weight ratios in water, to identify optimum polymer combinations. However, drug loaded (DL) wafers were prepared using 45% v/v ethanol to help complete solubilization of the aspirin. The formulations were characterized using texture analyzer (hardness, mucoadhesion), scanning electron microscopy (SEM), X-ray diffractometry (XRD), attenuated total reflection-Fourier transform infrared (ATR-FTIR), differential scanning calorimetry (DSC), thermogravimetric analyzer (TGA), and swelling capacity. Wafers with higher total polymer concentration were more resistant to penetration (MET:CAR 1:1 samples B2, C2) and MET:CS 1:1 (sample E2) and MET:CS 3:1 (sample F2) and also depended on the ratios between the polymers used. From the characterization, samples C2, B2, E2 and F2 showed the most ideal characteristics. XRD showed that BLK wafers were amorphous, whilst the DL wafers were crystalline due to the presence of aspirin. SEM confirmed the presence of pores within the polymer matrix of the BLK wafers, whilst DL wafers showed a more compact polymeric matrix with aspirin dispersed over the surface. The DL wafers showed a good flexibility required for transportation and patient handling and showed higher swelling capacity and adhesion values with phosphate buffer saline (PBS) than with simulated saliva (SS). Drug dissolution studies showed that aspirin was rapidly released in the first 20 minutes and then continuously over 1 hour. FTIR confirmed the interaction of aspirin with the polymers evidenced by peak shifts around 1750 cm-1 and the broad peak between 2500 to3300 cm-1. Lyophilized CAR: CS 1:3 (sample DL13), MET:CS 1:3 (sample DL8) and MET:CAR 3:1 (sample DL1) wafers seem to be a very promising system for the administration of low dose aspirin for older patients with dysphagia.

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Section: Mechanical Properties Of the Wafersmentioning

confidence: 99%

Development and functional characterization of composite freeze dried wafers for potential delivery of low dose aspirin for elderly people with dysphagia

Farias

Boateng

2018

International Journal of Pharmaceutics

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“…Algae refer to photosynthetic organisms with a complex and controversial taxonomy [7]. To date, more than 20,000 species of algae have been identified and there are two kinds of algae depending on size [6].…”

Section: Introductionmentioning

confidence: 99%

“…Marine macroalgae are be classified into three species according to their pigments: Phaeophyceae (brown macroalgae, Chromophyta), Chlorophyta (green macroalgae) and Rhodophyta (red macroalgae) [6,8]. In contrast, microalgae are unicellular or simple multicellular species that have the little size and found in various environments [6,7].…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Marine Algae-Derived Carbohydrates for Skin Health

Kim

Lee

Kim

et al. 2018

Preprint

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Marine algae have been considered as abundant source of bioactive compounds with cosmeceutical potential. Recently, a great deal of interest has focused on the health-promoting effects of marine bioactive compounds. Carbohydrate is a major and abundant constitute of marine algae that have been utilized in cosmetic formulations, such as moisturizing and thickening agents. In addition, marine carbohydrates have been suggested as promising bioactive biomaterials for various skin beneficial properties, such as anti-oxidant, anti-melanogenic and anti-skin aging. Therefore, marine algae carbohydrates have potential of skin health benefits for value-added cosmeceutical application. The present review focused on the various biological capacities and potential skin health benefits of bioactive marine carbohydrates.

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“…Gelatin is a substantially pure protein food ingredient obtained by a mild heat treatment of collagen under acidic or alkaline conditions and extensively used in food packaging application due to its edible or biodegradable nature, low cost, and wide availability of sources . Furthermore, its compounding with starch for food packaging applications have been reported in several studies .…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of antimicrobial starch‐based nanocomposite films and modeling the process parameters via the RSM

2018

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The main aim of this study is the design and fabrication of degradable nanocomposite films composed of starch/gelatin (S/G)/SiO2 suitable for food packaging applications. Response surface methodology (RSM) was applied to design the fabrication process and to investigate the effect of S/G weight ratio and SiO2 weight percent (wt.%) on the mechanical and barrier properties of the prepared samples. The results revealed that tensile strength and modulus were increased with increasing S/G wt. ratio and introducing SiO2 into the polymer matrix, while elongation at break and water vapor permeability (VWP) decreased. The process optimization was done and various properties of the optimized films such as morphological properties, thermal properties, VWP, degradability, and antibacterial properties were investigated. It was found that the thermal stability of the optimized sample as well as its barrier property against water vapor were improved dramatically as SiO2 presented into the matrix due to proper dispersion and interaction of nanoparticles with the polymer matrix as also confirmed via scanning electron microscopy images. Furthermore, SiO2 has brought significant antibacterial properties for the S/G matrix that is a notable feature for food packaging films. Overall, the results of the current study confirm the S/G/SiO2 compounding could be proper candidate for fabrication of antibacterial degradable food packaging films. POLYM. COMPOS., 39:E584–E591, 2018. © 2018 Society of Plastics Engineers

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A review on synthesis, properties and applications of natural polymer based carrageenan blends and composites

Cited by 368 publications

References 282 publications

Development and functional characterization of composite freeze dried wafers for potential delivery of low dose aspirin for elderly people with dysphagia

Development and functional characterization of composite freeze dried wafers for potential delivery of low dose aspirin for elderly people with dysphagia

Beneficial Effects of Marine Algae-Derived Carbohydrates for Skin Health

Fabrication and characterization of antimicrobial starch‐based nanocomposite films and modeling the process parameters via the RSM

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