A Review on Synthetic and Pharmacological Potential of Compounds Isolated from Garcinia mangostana Linn

Saraswathy, Swathy Unnikrishna Pillai; Lalitha, Lekshmi Chandran Pillai; Rahim, Sherifa; Gopinath, Chithra; Haleema, Simimole; SarojiniAmma, Sumalekshmy; Aboul‐Enein, Hassan Y.

doi:10.1016/j.phyplu.2022.100253

Cited by 13 publications

(2 citation statements)

References 118 publications

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“…In this study we assessed the influence of green Ag-NPs using G. mangostana peel extracts as ant proliferative activity against human breast cancer cell line MCF-, it is proved that a probable relevance between antioxidant activity and cancer inhibition of cell growth (Wathoni et al, 2020;Saraswathy et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Effect of biosynthesized silver nanoparticles by Garcinia mangostana extract against human breast cancer cell line MCF-7

et al. 2022

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Breast cancer is the greatest common malignancy in females. This syndrome represents a serious public health problem that needs additional study to define its prediction and specific treatment. MCF-7 is a usually used breast cancer cell line that has been spread for many years by multiple groups. It shows to be a suitable model cell line for breast cancer studies worldwide, including those concerning anticancer. Anticancer and anti-inflammatory influences are important to treat the threats of chronic inflammation related with chronic diseases. Natural products have made and are remaining to make vital influences to the search for new anticancer agents. The use of natural foodstuffs in relationship with green nanoparticles has drawn attention because of its easy and eco-friendly protocol. Therefore, we aimed to investigate the antiproliferative activity of silver nanoparticles biosynthesized by mangosteen peel extract (MPE) on human breast cancer cell line (MCF-7) using [3-(4, 5-dimethylthiazolyl)-2, 5-diphenyl-tetrazolium bromide (MTT) method. In the present study serial concentrations (5, 10, 15, 50, 70, µg/mL) of cells biosynthesized silver nanoparticles by (MPE) was tested against MCF-7 cell lines showed a cytotoxic effects, morphological degeneration, damaging and has more effectiveness against breast cancer cells. The results showed a substantial a high reducing power, a sensible antiproliferative role and antioxidant activity. The results showed that silver nanoparticles biosynthesized by mangosteen peel extract (MPE) can be regarded as a suitable candidate for designing anticancer pharmaceutical preparations.

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Section: Discussionmentioning

confidence: 99%

Effect of biosynthesized silver nanoparticles by Garcinia mangostana extract against human breast cancer cell line MCF-7

et al. 2022

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“…It plays an important role in many processes, such as protein folding stability and trafficking, assembly, biosynthesis of coenzyme A, detoxification of heavy metals, and redox balance. , Inside cells, l -cysteine is the prevailing form due to the highly reducing conditions . The thiol group present in the structure of cysteine makes it a unique amino acid, which can undergo a variety of different nucleophilic reactions and increase its affinity to enzyme binding sites of metals, such as zinc or iron. , Xanthene and thioxanthene are tricyclic structures; many derivatives of these structures showed anticancer and biological activities. − …”

Section: Introductionmentioning

confidence: 99%

Biological Evaluation of Xanthene and Thioxanthene Derivatives as Antioxidant, Anticancer, and COX Inhibitors

Abualhasan,

Hawash,

Aqel

et al. 2023

ACS Omega

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Xanthene and thioxanthene analogues have been investigated for their potential as anticancer and anti-inflammatory agents. Additionally, cysteine analogues have been found to possess antioxidant, anti-inflammatory, and anticancer activities due to their role in cellular redox balance, scavenging of free radicals, and involvement in nucleophilic reactions and enzyme binding sites. In this study, we synthesized a library of tertiary alcohols derived from xanthene and thioxanthene, and further, some of these compounds were coupled with cysteine. The objective of this research was to explore the potential anticancer, antioxidant, and anti-inflammatory activities of the synthesized compounds. The synthesized compounds were subjected to test for anticancer, antioxidant, and anti-inflammatory activities. Results indicated that compound 3 exhibited excellent inhibition activity (IC50 = 9.6 ± 1.1 nM) against colon cancer cells (Caco-2), while compound 2 showed good inhibition activity (IC50 = 161.3 ± 41 nM) against hepatocellular carcinoma (Hep G2) cells. Compound 4 demonstrated potent antioxidant inhibition activity (IC50 = 15.44 ± 6 nM), and compound 7 exhibited potent anti-inflammatory activity with cyclooxygenase-2 (COX-2) inhibition IC50 (4.37 ± 0.78 nM) and high selectivity for COX-2 (3.83). In conclusion, certain synthesized compounds displayed promising anticancer activity and anti-inflammatory effects. Nevertheless, additional research is necessary to create more analogues, develop a more distinct comprehension of the structure–activity relationship (SAR), and perform in vivo experiments to evaluate the pharmacokinetic and pharmacodynamic characteristics of the compounds under examination. Such research may pave the way for the development of novel therapeutic agents with potential applications in cancer and inflammatory diseases.

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Traditional Herbal Medicine for Dementia Therapy

Sosa,

Hassan

2024

Nutritional Neurosciences

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A Review on Synthetic and Pharmacological Potential of Compounds Isolated from Garcinia mangostana Linn

Cited by 13 publications

References 118 publications

Effect of biosynthesized silver nanoparticles by Garcinia mangostana extract against human breast cancer cell line MCF-7

Effect of biosynthesized silver nanoparticles by Garcinia mangostana extract against human breast cancer cell line MCF-7

Biological Evaluation of Xanthene and Thioxanthene Derivatives as Antioxidant, Anticancer, and COX Inhibitors

Traditional Herbal Medicine for Dementia Therapy

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