A review on the effect of COVID-19 in type 2 asthma and its management

Ghosh, Srijit; Das, Saibal Kumar; Mondal, Rupsa; Abdullah, Salik; Sultana, Shirin; Singh, Sukhbir; Sehgal, Aayush; Behl, Tapan

doi:10.1016/j.intimp.2020.107309

Cited by 21 publications

(17 citation statements)

References 108 publications

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“…Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are the SARS-Cov2 receptors highly expressed in patients with asthma [12]. Asthma can be harnessed by ACE inhibitors, including lisinopril and enalapril, but patients with asthma must remain alert during the COVID-19 pandemic [13]. Depending on Th response polarization, the role of eosinophils in fighting against the COVID-19 infection is yet to be studied.…”

Section: Fig (1)mentioning

confidence: 99%

Post-Coronavirus Era: Should We Expect a Surge in Allergic Diseases and Asthma?

Nasab¹,

Athari²

2021

TOPHJ

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Some infectious agents by priming the immune system promote protection against allergy and asthma. During infections, Th1 immune responses are dominant, while in allergic conditions, Th2 responses are more pronounced. Th1 immune response protects the body against infections, and Th2 response leads to allergy and asthma. For maintaining health, the balance between Th1 and Th2 responses is necessary. The COVID-19 infection augments Th1 and also eosinophilic responses. On the other hand, the main protocols to control the COVID-19 pandemic require adherence to health standards, maintaining personal hygiene, frequent disinfecting of hands, using face masks, etc. In the post-COVID-19 era, this sterile condition may relinquish, and the Th1/Th2 immune imbalance may lead to an increase in the incidence of allergy and asthma. Therefore, focus on the COVID-19 infection should not deter us from foreseeing a surge in asthma and other post-coronavirus problems.

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Section: Fig (1)mentioning

confidence: 99%

Post-Coronavirus Era: Should We Expect a Surge in Allergic Diseases and Asthma?

Nasab¹,

Athari²

2021

TOPHJ

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“…[33] Respiratory diseases COPD and asthma are the two most common and dangerous airway diseases. [104] Both are characterized by the presence of chronic infl ammation. [105,106] These patients present with changes to lung anatomy and to the blood vessels that feed them.…”

Section: Review Articlementioning

confidence: 99%

“…[38] Asthma Bronchial asthma is a heterogenous disease characterized by chronic airway infl ammation and variable remodeling, with a variety of clinical presentations and responses to treatment. [110] Most viral infections exacerbate asthma, [104,111,112] generally by inducing Th2-mediated responses, and high levels of proinfl ammatory cytokines and proinfl ammatory cytokine receptors. [111] Many of these reactions also appear during acute asthma attacks.…”

Section: Review Articlementioning

confidence: 99%

“…[114][115][116] Asthmatic patients generally have more comorbidities; however, greater severity and higher mortality levels have not been seen in COVID-19-positive asthmatics. [88,104,117] This may not be contradictory, as the course of COVID-19 in asthmatics depends on the persistence and severity of the patient's asthma. To avoid or reduce risk of COVID-19 complications in asthmatics, it is important to control both the asthma and its inter-crisis treatment, which prevents structural and functional damage to the tracheobronchial tree.…”

Section: Review Articlementioning

confidence: 99%

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2021

MEDICC Review

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MEDICC Review is a unique open-access platform for Latin American and Caribbean praxis addressing today's critical interactions between human health, development of sustainable societies, and the health of our planet. Drawing upon the contributions of the region in social medicine, social movements, rich diversity and scientifi c prowess, Latin America and Caribbean authors published in the journal can help fi ll gaps in thinking and evidence sorely needed to build a sustainable future and a hopeful legacy for future generations.We look forward to contributing to increased visibility for their work and to its positive impact on both regional integration and worldwide solutions.MEDICC Review is published by MEDICC, a US nonprofi t organization founded in 1997, based in Oakland, California, USA, and dedicated to US, Cuban and global health cooperation and equity.

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“…Contrary to popular belief, certain data show that COVID-19 severity is reduced in type 2 asthmatic patients with elevated T-cells, since most COVID-19 positive individuals have a significant drop in T-cells. This helps to restore the balance of immunological responses, slowing the advancement of the disease (Ghosh et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Current trends in diagnosis and treatment strategies of COVID-19 infection

Tiwari¹,

Kumar

Tiwari³

et al. 2021

Environ Sci Pollut Res

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Coronaviruses are terrifically precise and adapted towards specialized respiratory epithelial cells, observed in organ culture and human volunteers both. This virus is found to possess an unpredictable anti-viral T-cell response which in turn results in T-cell activation and finally apoptosis, leading to cytokine storm and collapse of the whole immune system. The present review provides comprehensive information regarding SARS-CoV-2 infection, mutant strains, and the impact of SARS-COV-2 on vital organs, the pathophysiology of the disease, diagnostic tests available, and possible treatments. It also includes all the vaccines developed so far throughout the world to control this pandemic. Until now, 18 vaccines have been approved by the WHO and further 22 vaccines are in the third trial. This study also provides up-to-date information regarding the drugs repurposed in clinical trials and the recent status of allopathic drugs along with its result. Although vaccines are available, specific treatment is not available for the disease. Furthermore, the effect of vaccines on new variants is a new area of research at this time. Therefore, a preventive attitude is the best approach to fight against this virus.

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A review on the effect of COVID-19 in type 2 asthma and its management

Abstract: Graphical abstract

Cited by 21 publications

References 108 publications

Post-Coronavirus Era: Should We Expect a Surge in Allergic Diseases and Asthma?

Post-Coronavirus Era: Should We Expect a Surge in Allergic Diseases and Asthma?

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Current trends in diagnosis and treatment strategies of COVID-19 infection

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