A review on the ethnobotany, phytochemistry, pharmacology and toxicology of butterbur species (Petasites L.)

Malagón

et al. 2023

Plants

The present study describes the chemical and enantiomeric composition of a new essential oil, distilled from the dry leaves of Gynoxys buxifolia (Kunth) Cass. The chemical analysis was conducted by GC-MS and GC-FID, on two orthogonal capillary columns. A total of 72 compounds were detected and quantified with at least one column, corresponding to about 85% by weight of the whole oil mass. Of the 72 components, 70 were identified by comparing the respective linear retention indices and mass spectra with data from the literature, whereas the two main constituents were identified by preparative purification and NMR experiments. The quantitative analysis was carried out calculating the relative response factor of each compound according to their combustion enthalpy. The major constituents of the EO (≥3%) were: furanoeremophilane (31.3–28.3%), bakkenolide A (17.6–16.3%), caryophyllene oxide (6.0–5.8%), and (E)-β-caryophyllene (4.4%). Additionally, the hydrolate was also analyzed with respect to the dissolved organic phase. About 40.7–43.4 mg/100 mL of organic compounds was detected in solution, of which p-vinylguaiacol was the main component (25.4–29.9 mg/100 mL). Finally, the enantioselective analysis of some chiral terpenes was carried out, with a capillary column based on β-cyclodextrin chiral stationary phase. In this analysis, (1S,5S)-(−)-α-pinene, (1S,5S)-(−)-β-pinene, (S)-(+)-α-phellandrene, (S)-(+)-β-phellandrene, and (S)-(−)-terpinen-4-ol were detected as enantiomerically pure, whereas (S)-(−)-sabinene showed an enantiomeric excess of 69.2%. The essential oil described in the present study is a good source of two uncommon volatile compounds: furanoeremophilane and bakkenolide A. The former lacks bioactivity information and deserves further investigation, whereas the latter is a promising selective anticancer product.

Section: Discussionmentioning

confidence: 97%

The Leaf Essential Oil of Gynoxys buxifolia (Kunth) Cass. (Asteraceae): A Good Source of Furanoeremophilane and Bakkenolide A

Malagón

et al. 2023

Plants

“…It is commonly known that, some Western traditional medicine herbs, such as butterbur ( Petasites hybridus ), feverfew ( Tanacetum parthenium L.) and rosemary ( Rosmarinus officinalis L.) are evidenced beneficial for migraine ( Ghasemzadeh Rahbardar and Hosseinzadeh, 2020 ; Hiemori-Kondo, 2020 ; Darbahani et al, 2022 ; Kulinowski et al, 2022 ). However, they were not identified by this Chinese medicine classical literature data-mining research.…”

Section: Discussionmentioning

confidence: 99%

Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature

et al. 2022

Background: Treatment effect of current pharmacotherapies for migraine is unsatisfying. Discovering new anti-migraine natural products and nutraceuticals from large collections of Chinese medicine classical literature may assist to address this gap.Methods: We conducted a comprehensive search in the Encyclopedia of Traditional Chinese Medicine (version 5.0) to obtain migraine-related citations, then screened and scored these citations to identify clinical management of migraine using oral herbal medicine in history. Information of formulae, herbs and symptoms were further extracted. After standardisation, these data were analysed using frequency analysis and the Apriori algorithm. Anti-migraine effects and mechanisms of actions of the main herbs and formula were summarised.Results: Among 614 eligible citations, the most frequently used formula was chuan xiong cha tiao san (CXCTS), and the most frequently used herb was chuan xiong. Dietary medicinal herbs including gan cao, bai zhi, bo he, tian ma and sheng jiang were identified. Strong associations were constructed among the herb ingredients of CXCTS formula. Symptoms of chronic duration and unilateral headache were closely related with herbs of chuan xiong, gan cao, fang feng, qiang huo and cha. Symptoms of vomiting and nausea were specifically related to herbs of sheng jiang and ban xia.Conclusion: The herb ingredients of CXCTS which presented anti-migraine effects with reliable evidence of anti-migraine actions can be selected as potential drug discovery candidates, while dietary medicinal herbs including sheng jiang, bo he, cha, bai zhi, tian ma, and gan cao can be further explored as nutraceuticals for migraine.

“…25,26 A disadvantage of the ethyl acetate extract of the plant root is that it contains a high level of toxic pyrrolizidine alkaloids. 7 However, the leaves of Petasite species contain a negligible level of pyrrolizidine. 1,7 Based on our results, the cytotoxicity estimates of leaf, petiole and rhizome extracts indicate that P. japonicus is a repository for anticancer compounds, and the fact that the IC50 values are significantly lower than the NCI criteria indicates its potential for cancer drug discovery programs.…”

Section: Cytotoxic Effects Of Fractionsmentioning

confidence: 99%

“…[1][2][3] The bioactive compounds of Petasites species roots are sesquiterpenes, such as petasin or isopetasin. [4][5][6][7] A disadvantage of the extract of the plant root is that it contains a high level of toxic pyrrolizidine alkaloids. 8,9 However, the areal parts of Petasites species, which contain a negligible amount of pyrrolizidine, 8 have been reported to contain relatively lower polar compounds such as petasitin, S-petasin, S-petasitin, petasinol, and Sisopetasin.…”

Section: Introductionmentioning

confidence: 99%

“…8,9 However, the areal parts of Petasites species, which contain a negligible amount of pyrrolizidine, 8 have been reported to contain relatively lower polar compounds such as petasitin, S-petasin, S-petasitin, petasinol, and Sisopetasin. 7 Ethnobotanical and ethnopharmacological data describing plants with potential therapeutic activities are more economical and beneficial for identifying potential anticancer molecules than mass screening of plant species. Plants have long been used for their therapeutic values, and 85,000 plants have been documented for therapeutic use globally.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In Vitro Anticancer Activity of Hexane and Ethyl acetate Extracts of Leaf, Petiole and Rhizome of Petasites japonicus

2023

TJNPR

Cancer is one of the most dangerous diseases in humans; accordingly, there is considerable demand for discovery of new anticancer agents from natural products. [12][13][14] The potential for using natural products as anticancer drugs was recognized in 1950 by the United States Natural Cancer Institute (NCI). 15 Since then, many naturally occurring anticancer drugs have been identified. 16,17 Despite the recent dominance of synthetic chemistry as a method to discover and produce drugs, there is still enormous potential for bioactive plants or their extracts to provide new and novel products for disease treatment and prevention. 18,19 Plants have an almost unlimited capacity to produce substances that attract researchers in the quest for novel chemotherapeutics. 18 The continuing search for new anticancer compounds in plants and traditional foods is a realistic and promising strategy for its prevention. 20 The objective of this study was to investigate the anticancer activity of the hexane, ethyl acetate, butanol and aqueous fractions of extract of Petasites japonicus Max plant parts against four human cancer cell lines. Materials and Methods Plant materialsWild Petasites japonicus Max was collected in September 2019 from Chungdogun, Gyungbuk Province, Korea, and processed and divided into leaves, petioles, and rhizomes. The plant species was verified by Dr. Young Whan Choi, and a voucher specimen (No.