A review on the gastrointestinal protective effects of tropical fruit polyphenols

Jiang, Qianer; Charoensiddhi, Suvimol; Xue, Xiaofeng; Sun, Biqi; Liu, Yang; El-Seedi, Hesham R.; Wang, Kai

doi:10.1080/10408398.2022.2145456

Cited by 20 publications

(17 citation statements)

References 188 publications

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“…To determine the similarities and differences across crop kinds, thorough metabolomic approaches utilizing various analytical methods have been devised. Untargeted research using LC-MS, GC-MS, and NMR has been done on a small number of crops, including melon, 164 raspberry, 118,165 cranberries, 166 tomato, 167,168 apples, 169,170 sweet pepper, 171 avocado, 172 potato, 173,174 and broccoli, 111 etc. Table 3 displays results from a few metabolomics analyses done on fruit that has been harvested.…”

Section: Metabolomics Assessment Of Food Quality and Safetymentioning

confidence: 99%

“…To evaluate the chemical makeup of potato cultivars, a metabolomics technique based on flow infusion electrospray ionization mass spectrometry (FIE-MS) and GC-MS was applied. 173,174 Results from-FIE-MS indicated significant variations between the tubers of potatoes of various cultivars. A substantial number of the discovered metabolites that significantly contributed to compositional variations between cultivars were revealed by GC-MS analysis to be closely related to the qualities of potato tubers.…”

Section: Metabolomics Assessment Of Food Quality and Safetymentioning

confidence: 99%

See 1 more Smart Citation

Emerging trends and applications of metabolomics in food science and nutrition

Zhang,

Sun,

Elmaidomy

et al. 2023

Food Funct.

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Section: Metabolomics Assessment Of Food Quality and Safetymentioning

confidence: 99%

Section: Metabolomics Assessment Of Food Quality and Safetymentioning

confidence: 99%

Emerging trends and applications of metabolomics in food science and nutrition

Zhang,

Sun,

Elmaidomy

et al. 2023

Food Funct.

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show abstract

“…Peptides of food protein origin have a wide range of biological functions and are used to various degrees in biomaterial development, the food industry, and peptide-based therapeutics [ 11 , 12 ]. The angiotensin-converting enzyme inhibitor Ile–Arg–Trp (IRW) is a food-derived oligopeptide that was identified in the egg protein ovotransferrin [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

IRW (Ile–Arg–Trp) Alleviates DSS–Induced Intestinal Injury by Remodeling Gut Microbiota and Regulating Fecal SCFA Levels

Fei

Wang

et al. 2023

Nutrients

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Inflammatory bowel disease (IBD) is a chronic disease of unknown etiology with a progressive and destructive course and an increasing incidence worldwide. Dietary peptides have a variety of biological functions and are effective anti-inflammatories and antioxidants, making them a prospective class of material for treating intestinal inflammation. Our study investigated the association between Ile–Arg–Trp (IRW), a dietary oligopeptide, and intestinal microbial changes during the relief of colitis using different concentrations of IRW. We found that IRW can significantly alleviate mouse colonic barrier damage caused by dextran sulphate sodium salt (DSS) and promote intestinal health. The results of microbial community composition showed that the relative abundance of Bacillota and Lactobacillus in the gut microbiota at different concentrations of IRW was significantly increased and that the abundance of Bacteroides was suppressed. Surprisingly, the relative abundance of Odoribacter also received regulation by IRW concentration and had a positive correlation with acetic acid. IRW at 0.02 mg/mL and 0.04 mg/mL significantly altered the abundance of Bacillota, Odoribacter, and Lactobacillus.

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“…12,25, 26 The gut microbiome has been found to assist in infection resistance as well as the synthesis of all kinds of essential nutrients. 27 Studies have demonstrated that clinical AD indicators are negatively correlated with Akkermansia and Bif idobacterium abundance, which are lactateand propionate-producing bacteria, respectively, 13 and pos-itively correlated with Clostridium abundance. 28 Bif idobacterium suppresses neuroinflammation and modulates the microbiota, thereby exerting neuroprotective effects against AD.…”

Section: Introductionmentioning

confidence: 99%

“…Relevant research findings indicate that the microbiota–gut–brain axis significantly influences brain functions, such as AD disease. ,, AD induces dysregulation of gut microbiota imbalance, including quantitative and composition changes in the gut microbiome. ,, The gut microbiome has been found to assist in infection resistance as well as the synthesis of all kinds of essential nutrients . Studies have demonstrated that clinical AD indicators are negatively correlated with Akkermansia and Bifidobacterium abundance, which are lactate- and propionate-producing bacteria, respectively, and positively correlated with Clostridium abundance …”

Section: Introductionmentioning

confidence: 99%

Effect of Human Milk Oligosaccharides on Learning and Memory in Mice with Alzheimer’s Disease

Gao,

Fang,

Sun

et al. 2023

J. Agric. Food Chem.

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Alzheimer's disease (AD) is distinguished by cognitive dysfunction and neuroinflammation in the brain. 2′-Fucosyllactose (2′-FL) is a major human milk oligosaccharide (HMO) that is abundantly present in breast milk and has been demonstrated to exhibit immunomodulatory effects. However, the role of 2′-FL and HMO in gut microbiota modulation in relation to AD remains insufficiently investigated. This study aimed to elucidate the preventive effect of the 2′-FL and HMO impact of AD and the relevant mechanism involved. Here, the behavioral results showed that 2′-FL and HMO intervention decreased the expression of Tau phosphorylation and amyloid-β (Aβ), inhibited neuroinflammation, and restored cognitive impairment in AD mice. The metagenomic analysis proved that 2′-FL and HMO intervention restored the dysbiosis of the gut microbiota in AD. Notably, 2′-FL and HMO intervention significantly enhanced the relative abundance of Clostridium and Akkermansia. The metabolomics results showed that 2′-FL and HMO enhanced the oleoyl-L-carnitine metabolism as potential drivers. More importantly, the levels of oleoyl-L-carnitine were positively correlated with the abundances of Clostridium and Akkermansia. These results indicated that 2′-FL and HMO had therapeutic potential to prevent AD-induced cognitive impairment, which is of great significance for the treatment of AD.

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A review on the gastrointestinal protective effects of tropical fruit polyphenols

Cited by 20 publications

References 188 publications

Emerging trends and applications of metabolomics in food science and nutrition

Emerging trends and applications of metabolomics in food science and nutrition

IRW (Ile–Arg–Trp) Alleviates DSS–Induced Intestinal Injury by Remodeling Gut Microbiota and Regulating Fecal SCFA Levels

Effect of Human Milk Oligosaccharides on Learning and Memory in Mice with Alzheimer’s Disease

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