A review on the genus Melodinus: traditional uses, phytochemical diversity and pharmacological activities of indole alkaloids

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

“…These substances are predominantly found in the plant families Oleaceae Hoffmans. and Rubiaceae Juss, exhibiting a range of structures from simple indoles to complex bisindoles ( Teng et al, 2023 ). In the field of antiseizure pharmacotherapy, indole alkaloids target a range of molecular receptors, effectively regulating neurotransmitter movement and ion channel activities.…”

Aza-Achmatowicz rearrangement coupled with intermolecular aza-Friedel–Crafts enables total syntheses of uleine and aspidosperma alkaloids

“…3000 members) with diverse biological activities and intricate skeletal diversity. [1][2][3][4][5][6][7] They continue to inuence the research elds of natural products, drug discovery, biochemistry, and especially organic chemistry (total synthesis and methodology development). 8,9 Structurally, the direct covalent C3-C2 0 linkage of indole (in blue) with piperidine (in red) characterizes this subclass of alkaloids and thus has sparked great interest from generations of organic chemists in developing novel and efficient synthetic strategies (Scheme 1c).…”

Total Synthesis of Putative Melognine

“…Melognine was reported in 2021 as a novel monoterpenoid indole alkaloid isolated from Melodinus fusiformis , showing the ability to induce apoptosis in BT549 cells (Figure ). The atypical [6–6–6–5–5–6] hexacyclic skeleton, containing a bicyclo[3.2.1]­octane fused with a tetrahydroquinoline and a hexahydroindolizine, was elucidated by NMR techniques and was supported by the structures of known alkaloids meloscine and scandine. The structures of these two alkaloids were confirmed by X-ray crystallography and by total syntheses. , The highly fused structure of melognine as well as five contiguous stereogenic centers, three of which are quaternary carbons, attracted our attention as a synthetic target, and we initiated our synthetic program toward the hexacyclic natural product.…”