A review on the oxidative and nitrosative stress (O&amp;NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

Maes, Michaël; Gałecki, Piotr; Chang, Yong Seun; Berk, Michael

doi:10.1016/j.pnpbp.2010.05.004

Cited by 1,048 publications

(855 citation statements)

References 246 publications

Supporting

Mentioning

818

Contrasting

Unclassified

Order By: Relevance

“…In support of these ideas, depressogenic paradigms causing ‘psychological’ stress in rodents (e.g., restraint stress) have been shown to generate oxidative damage leading to the accumulation of malondialdehydes (MDA) or 4‐hydroxy‐2‐nonenals (4‐HNE). Consistent with our findings that Mianserin protects from oxidative stress in C. elegans , antidepressant treatment in rodents suppresses the accumulation of oxidative stress markers MDA and 4‐HNE generated by restraint stress in rodents (Abdel‐Wahab & Salama, 2011; Maes et al ., 2011; Spiers et al ., 2013). Similarly, patients suffering from major depression show increased oxidative damage and reduced antioxidant capacity in the blood (Scapagnini et al ., 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Multiple antioxidants, such as N‐acetyl‐cysteine (NAC), glutathione, and tocopherol, have antidepressant‐like effects in rodents in the tail suspension test. Furthermore, in patients, NAC was found to have antidepressant‐like effects in randomized clinical trials (Maes et al ., 2011). Interestingly, dietary restriction, a well‐established method to extend lifespan that also reduces oxidative damage, was found to have antidepressant effects in mice (Lutter et al ., 2008).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response

et al. 2015

View full text Add to dashboard Cite

SummaryOxidative stress has long been associated with aging and has recently been linked to psychiatric disorders, including psychosis and depression. We identified multiple antipsychotics and antidepressants that extend Caenorhabditis elegans lifespan and protect the animal from oxidative stress. Here, we report that atypical antidepressants activate a neuronal mechanism that regulates the response to oxidative stress throughout the animal. While the activation of the oxidative stress response by atypical antidepressants depends on synaptic transmission, the activation by reactive oxygen species does not. Lifespan extension by atypical antidepressants depends on the neuronal oxidative stress response activation mechanism. Neuronal regulation of the oxidative stress response is likely to have evolved as a survival mechanism to protect the organism from oxidative stress, upon detection of adverse or dangerous conditions by the nervous system.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response

et al. 2015

View full text Add to dashboard Cite

show abstract

“…There is now evidence that depression is accompanied by an increase in O&NS as indicated by an increase in lipid peroxidation, oxidative and nitrosative damage to DNA, nitrosative damage to proteins, hypernitrosylation, autoimmune responses to oxidatively and nitrosatively modified epitopes (neoepitopes, including malondialdehyde (MDA), oxidized LDL and NO-adducts 93,94 . These activated O&NS pathways are partly related to lowered levels of key antioxidants including lowered levels of coenzyme Q10, zinc, vitamin E, glutathione, HDL-cholesterol, albumin, etc.…”

Section: Effects Of Oxidative and Nitrosative Stress (Oandns)mentioning

confidence: 99%

“…These activated O&NS pathways are partly related to lowered levels of key antioxidants including lowered levels of coenzyme Q10, zinc, vitamin E, glutathione, HDL-cholesterol, albumin, etc. 93 . Both the activated O&NS pathways and lowered levels of key antioxidants may be associated with different symptom profiles, the specific neurotransmitter pathophysiology of depression and staging of depression including chronicity of depression (e.g.…”

Section: Effects Of Oxidative and Nitrosative Stress (Oandns)mentioning

confidence: 99%

Depression in cancer: The many biobehavioral pathways driving tumor progression

Bortolato

Hyphantis

Valpione

et al. 2017

Cancer Treatment Reviews

Self Cite

261

179

View full text Add to dashboard Cite

Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote:(1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic-pituitary-adrenal axis. Consequently, the prompt recognition of depression among patients with cancer who may benefit of treatment strategies targeting depressive symptoms, cognitive dysfunction, fatigue and sleep disturbances, is a public health priority. Moreover, behavioral strategies aiming at reducing psychological distress and depressive symptoms, including addressing unhealthy diet and life-style choices, as well as physical inactivity and sleep dysfunction, may represent important strategies not only to treat depression, but also to improve wider cancer-related outcomes. Herein, we provide a comprehensive review of the intertwined biobehavioural pathways linking depression to cancer progression. In addition, the clinical implications of these findings are critically reviewed.

show abstract

“…cognitivedysfunction 3 .Recently, oxidative stress has been proposed as a contributing factor in the pathogenesis of depression 4 .Again, significantly lower plasma concentrations of several key antioxidants (vitamin-E,zinc and coenzyme Q),as wellas lower antioxidant enzyme activity, have been reported in major depression 5 .Depression is aneuropsychiatric illness that has been estimated to be third among the global burden of diseases 6 .…”

Section: Introductionmentioning

confidence: 99%

Effect of Oyster Mushroom on Kidney in Stress Induced Depressed Rats

Jahan¹,

Akhter

Sultana

2017

J Bangladesh Soc Physiol

View full text Add to dashboard Cite

Background: Depression is associated with stressful condition which may cause kidney damage. Oyster mushroom (plurotus florida) may have free radical scavenging activity thereby can be used for the prevention and treatment for kidney damage. Objective: to observe the effect of oyster mushroom (plurotus florida) on kidney in restraint stress induced depressed rats. Methods: This experimental study was conducted from July 2012 to June 2013 in the Department of Physiology, Sir Salimullah Medical College( SSMC), Mitford, Dhaka. Thirty Wister albino male rats, aged 90 to 100 days, weighing 150 to 180g (initial body weight) were used in the present study. Then they were divided into Group I (Control group, without mushroom n=20) and Group II (Experimental group, depressed rats supplemented with mushroom n=10). Control group without mushroom again subdivided into Group Ia,( baseline control n=10) and Group Ib (depressed control n=10) . All groups of animals were received basal diet for 28 consecutive days started from the 1 st day of the study period. Group Ib (depressed control) and group II (depressed mushroom supplemented) were housed under controlled condition in rat immobilizer (made up of steel wire, measuring 9´´ x 2.75´´ of light weight) for 6 hour/day for 28 days for the development of stress induced depression. In addition, only group II received oyster mushroom extract (200 mg/kg body weight, orally) for the same period. One rat of Group Ib (depressed control) was expired after 10 days for unknown cause. All 29 rats were sacrificed on day 30. Then blood sample and kidneys specimen were collected. Initial (initial bw ) and final body weights (final bw) were measured. Then estimation of blood glucose and serum urea levels were done by standard laboratory technique. Histology of kidney was done by standard laboratory procedure. Statistical analysis was done by using SPSS windows Version -16. One way ANOVA and Bonferroni tests were done as applicable. Results: In this study blood glucose level and serum urea level was significantly higher and abnormal histological structure was found in stress induced depressed rats. After taking mushroom extract for 28 days all the parameters were improved. Conclusion: From this study it can be concluded that oyster mushroom(Pleurotus florida) which is excellent edible and nutritious, may have renoprotective effect.

show abstract

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

Cited by 1,048 publications

References 246 publications

Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response

Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response

Depression in cancer: The many biobehavioral pathways driving tumor progression

Effect of Oyster Mushroom on Kidney in Stress Induced Depressed Rats

Contact Info

Product

Resources

About