A review on the pharmacological effects of vitexin and isovitexin

He, Maoxian; Min, Jia-Wei; Kong, Weilin; He, Xiaohua; Li, Jun-Xu; Peng, Biwen

doi:10.1016/j.fitote.2016.09.011

Cited by 357 publications

(214 citation statements)

References 142 publications

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“…Vitexin was found in 93% of the accessions studied, and the highest levels (0.104 to 0.124 g kg −1 ) were detected in the #24, #60, #119, #129, #139, and #146 accessions, which were not significantly different from one another. Vitexin (apigenin‐8‐C‐glucoside) has recently received increased attention due to its wide range of pharmacological effects, including anti‐oxidant, anti‐cancer, anti‐inflammatory, anti‐hyperalgesic, anti‐Alzheimer's disease, anti‐hypertensive, anti‐spasmodic, anti‐depressant‐like, anti‐viral, and neuroprotective effects …”

Section: Resultsmentioning

confidence: 99%

Physicochemical characterization of ‘Cerrado’ cashew (Anacardium othonianum Rizzini) fruits and pseudofruits

et al. 2019

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BACKGROUND The Cerrado occupies 23% of Brazil. A. othonianum is a native Cerrado species that presents differently colored pseudofruits. This report describes the morphometric properties, physicochemical characterization, and phenolic and flavonoid compound compositions of 30 accessions of A. othonianum. RESULTS The morphometric properties show that an average fruit had 21.97 mm length, 18.61 mm width, and 11.13 mm thickness, with 2.52 g mass. The pseudofruits had 28.84 mm apex width with 12.83 g of mass. The hue parameters of the pseudofruits were 18.67 ± 2.00 and 83.32 ± 1.97° (P < 0.05), reflecting their red to yellow color. The titratable acidity of the accessions was 0.91 ± 0.09 to 3.02 ± 0.02% (P < 0.05), soluble solid content was 9.60 ± 0.17 to 13.47 ± 0.38 °Brix (P < 0.05), and pH ranged from 2.83 ± 0.06 to 3.83 ± 0.06 (P < 0.05). Fourteen flavonoid compounds were identified. The most common compounds in the accessions were vitexin (93% of the accessions), hesperidin (57% of the accessions), epicatechin (34% of the accessions), and kaempferol‐3‐O‐glucoside (30% of the accessions). Cluster analysis generated four groups with the traits ΔE, °h, C, soluble solid content, titratable acidity, pH, total flavonoids, and their identified compounds. CONCLUSIONS Although all accessions are A. othonianum, there the chemical composition and the physical characteristics of these fruits vary. This is the first report in the literature using wild accessions. Greater disclosure of the species characteristic is interesting because it can increase income for the local population. © 2019 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Physicochemical characterization of ‘Cerrado’ cashew (Anacardium othonianum Rizzini) fruits and pseudofruits

et al. 2019

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“…The isovitexin (apigenin-6-C-glucoside), an isomer of vitexin, generally occurring together with vitexin, and together are exhibiting diverse biological activities like anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects [45].…”

Section: Hydroalcoholic Fenugreekmentioning

confidence: 99%

Analysis of Phytoconstituent Profile of Fenugreek – Trigonella Foenuem-Graecum L. – Seed Extracts

et al. 2017

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ABSTRACT. Fenugreek (Trigonella foenum-graecum L.) is a well-known herb for its efficiency in the prevention/treatment of diabetes among other chronic diseases. The aim of present study was to analyse the phytoconstituent profile of aqueous and hydro-alcoholic extracts of fenugreek seeds produced in Hungary. The aqueous and hydro-aqueous extracts were analysed using a UHPLC-ESI-MS approach, and in the first 54, while in the second extract 67 phytoconstituents were identified that mostly corroborate the previously described health promoting effects of fenugreek. However, it remains a huge challenge to correlate the phytoconstituent composition of the two extracts with the generated dose dependent hormetic response and cytotoxic effects that were reported by us in case of some human breast cancerous cell lines.

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“…Blood was obtained right after animal's sacrifice, and serum melatonin level was measured. Vitexin is considered to have the ability to induce sleepness with antidiabetic and anti-inflammatory effects (Abbasi, Nassiri-Asl, Shafeei, & Sheikhi, 2012;Choi et al, 2014;He et al, 2016). Serum melatonin levels were significantly different between Veh-treated and PI extract (500 mg/kg)-treated animals (**, p < .01).…”

Section: Discussionmentioning

confidence: 98%

Sleep‐inducing effect of Passiflora incarnata L. extract by single and repeated oral administration in rodent animals

Kim

Yoon

et al. 2019

Food Science & Nutrition

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Social cost of insomnia in modern society is gradually increasing. Due to various social phenomena and lifestyles that take away the opportunity of good quality of sleep, problems of insomnia cannot be easily figured out. Prescription of sleeping pills for insomnia patients can cause other inconveniences due to their side effects beyond their intended purposes. On the other hand, Passiflora incarnata L. (PI) has been widely used in South America for several centuries, showing effectiveness for sleep, sedation, anxiety, and so on in the civilian population. However, reports on the treatment efficacy of this herbal medicinal plant for insomnia patients through standardization as a sleeping agent have been very rare. Therefore, we obtained leaves and fruits of PI (8:2 by weight) as powder to prepare an extract. It was then applied to C6 rat glioma cells to quantitate mRNA expression levels of GABA receptors. Its sleep‐inducing effect was investigated using experimental animals. PI extract (6 μg/ml) significantly decreased GABA receptors at 6 hr after treatment. Immobility time and palpebral closing time were significantly increased after single (500 mg/kg) or repeated (250 mg/kg) oral administration. In addition, blood melatonin levels were significantly increased in PI extract‐treated animals after both single and repeated administrations. These results were confirmed through several repeated experiments. Taken together, these results confirmed that PI extract had significant sleep‐inducing effects in cells and animals, suggesting that PI extract might have potential for treating human insomnia.

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A review on the pharmacological effects of vitexin and isovitexin

Cited by 357 publications

References 142 publications

Physicochemical characterization of ‘Cerrado’ cashew (Anacardium othonianum Rizzini) fruits and pseudofruits

Physicochemical characterization of ‘Cerrado’ cashew (Anacardium othonianum Rizzini) fruits and pseudofruits

Analysis of Phytoconstituent Profile of Fenugreek – Trigonella Foenuem-Graecum L. – Seed Extracts

Sleep‐inducing effect of Passiflora incarnata L. extract by single and repeated oral administration in rodent animals

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