There are around 60 global species belonging to the genus Sesbania which are commonly found to be grown in Africa, Australia, and Asia. The leaves of Sesbania grandiflora have been used in local traditional medicine since ancient times. Major chemical constituents are alkaloids, flavonoids, glycosides, tannin, anthraquinone, steroid, pholobatannins, and terpenoids. Isovestitol, medicarpin, sativan (isoflavonoids) and betulinic acid (tannin substance) are the major constituents responsible for antibacterial and antifungal, antioxidant, anti-urolithiatic, anticonvulsant and anxiolytic, and hepatoprotective properties. Also, the plant extract contains alkaloids, phenolics, tannins, triterpenoids, and sterols. All parts of S. grandiflora are used in traditional medicine and phytochemical investigations have been conducted on extracts of the leaves, seeds and roots of S. grandiflora to provide scientific validation of its properties.