A review on the role of antioxidants in the management of diabetes and its complications

Rahimi, Roja; Nikfar, Shekoufeh; Larijani, Bagher; Abdollahi, Mohammad

doi:10.1016/j.biopha.2005.07.002

Cited by 754 publications

(517 citation statements)

References 67 publications

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“…Musarrat et al has shown earlier that the accumulation of 8-OHdG in nuclear DNA had predictive significance for breast cancer risk assessment (Musarrat et al, 1996). It is widely postulated that the etiology of Type 2 diabetes has a strong association with oxidative stres (Rahimi et al, 2005). However, a number of studies on the role of oxidative stress in Type diabetes have shown inconsistent results (Bhatia et al, 2003), and this discrepancy may exist with respect to patient age, duration of diabetes, treatment methods, techniques used to measure oxidative stress etc.…”

Section: Discussionmentioning

confidence: 99%

Use of Oral Antidiabetic Drugs (Metformin and Pioglitazone) in Diabetic Patients with Breast Cancer: How Does It Effect on Serum Hif-1 Alpha and 8Ohdg Levels?

Harman¹,

Erten²,

Küçükzeybek³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: The aim was to investigate indicators related to DNA damage and cancer pathogenesis in Type II diabetes cases with breast cancer. It was planned to evaluate the relationship between these markers with oral antidiabetic drugs. Research Design and Methods: Fourty patients and 10 healthy individuals were included in the study. HIF-1α and 8-OHdG are examined in blood samples taken from these individuals with an ELISA Kit. Statistical analysis of data was performed with 95% confidence using Windows package program SPSS 15.0. Results: HIF-1α parameters were found to be meaningfully higher in the patient group than the controls in both pretreatment and posttreatment periods (p<0.05). No significant differences in terms of 8-OHdG between patients and controls. However, posttreatment serum HIF-1α ve 8-OHdG levels was found lower than pretreatment levels in patients receiving metformin, but not with pioglitazone. Conversely, serum 8-OHdG levels decreased significantly in these patients. When patients were evaluated according to the treatment groups (pioglitazone vs. metfformin) no significant differences in terms of serum HIF-1α and 8-OHdG levels between treatment groups. Conclusions: HIF-1α levels decreased significantly in the patient group receiving metformin. However, there was no significant difference in terms of HIF-1α levels in the patients receiving pioglitazone.

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Section: Discussionmentioning

confidence: 99%

Use of Oral Antidiabetic Drugs (Metformin and Pioglitazone) in Diabetic Patients with Breast Cancer: How Does It Effect on Serum Hif-1 Alpha and 8Ohdg Levels?

Harman¹,

Erten²,

Küçükzeybek³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Under the aerobic state, a rapid increase in pyruvate as a product of cytosolic glycolysis accelerates the PDH-mediated conversion of pyruvate to acetyl-CoA followed by mitochondrial NADH-dependent ATP synthesis together with surplus superoxide leakage, leading to oxidative stress that plays a central role in the pathogenesis of diabetes (40,41). Reasonably, the antioxidative effect of ATP6AP2 blockade (Fig.…”

Section: Atp6ap2 Contributes To Glucose Metabolismmentioning

confidence: 99%

ATP6AP2/(Pro)renin Receptor Contributes to Glucose Metabolism via Stabilizing the Pyruvate Dehydrogenase E1 β Subunit

Kanda

Noda

Ishida

2015

Journal of Biological Chemistry

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Background:The mechanism of efficient energy generation in the highly evolved mammalian retina remains incompletely understood. Results: ATP6PA2 interacts with the E1 ␤ subunit of pyruvate dehydrogenase, a key enzyme in aerobic energy generation, controlling its protein stability. Conclusion: ATP6AP2 contributes to glucose metabolism together with oxidative stress. Significance: The present data provide a novel insight into the biological function of ATP6AP2 in the retina.

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“…1 Several studies have demonstrated that oxidative stress, caused mainly by the formation of AGEs, induces the generation of free radicals that contribute to diabetes development and progression of the secomplications, this lead to cell and tissue damages, and among other causes aging. 2 Thus, agents that inhibit AGEs formation and /or decrease oxidative stress are believed to have the rapeutic potential in patients' with diabetes orage-related diseases.…”

Section: Introductionmentioning

confidence: 99%

In vitro study of anti-glycation and radical scavenging activities of the essential oils of three plants from Morocco: Origanum compactum, Rosmarinus officinalis and Pelargonium asperum

Ramdan¹,

Raja²,

Amakran³

et al. 2015

Phcog J

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Introduction:We have carried out our study on the chemical composition; anti-glycation andradical scavenging activities of Origanum compactum, Rosmarinus officinalis and Pelargonium asperum essential oils (EO) that were harvested in the northeast of Morocco. These plants have been traditionally used in medicine as a chief ingredient of many polyherbal formulations for the treatment of several pathologies. Method: The phytochemical study was revealed by GC-MS. The protein glycation inhibitory activity of EO extracted from these plant tissues was evaluated in vitro using the model system of bovine serum albumin and methylglyoxal. The measure of DPPH • radical reducing power was used to evaluate the antiradical activity. To test each fraction, we used the IC50 value previously obtained for the crude oils. Results: The phytochemical study of these essential oils showed that p-Thymol, Eucalyptol and Citronellal were respectively the major components in the three investigated EO of O.compactum, R. officinal is and P. asperum. More than 90% of the total components were detected. The extracts and fractions with glycation inhibitory activity also showed antiradical activity when the DPPH • radical reducing power was measured. Conclusion: The glycation inhibitory activity was correlated with the antiradical potency of the extracts. Thus, the positive glycation inhibitory and antiradical activities of these plants might suggest a possible role in targeting aging and diabetic complications.The presence of various bioactive compounds confirms the application of these plants for various diseases by traditional practitioners. However, isolation of individual phytochemical constituents may proceed to find a novel drug.

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A review on the role of antioxidants in the management of diabetes and its complications

Cited by 754 publications

References 67 publications

Use of Oral Antidiabetic Drugs (Metformin and Pioglitazone) in Diabetic Patients with Breast Cancer: How Does It Effect on Serum Hif-1 Alpha and 8Ohdg Levels?

Use of Oral Antidiabetic Drugs (Metformin and Pioglitazone) in Diabetic Patients with Breast Cancer: How Does It Effect on Serum Hif-1 Alpha and 8Ohdg Levels?

ATP6AP2/(Pro)renin Receptor Contributes to Glucose Metabolism via Stabilizing the Pyruvate Dehydrogenase E1 β Subunit

In vitro study of anti-glycation and radical scavenging activities of the essential oils of three plants from Morocco: Origanum compactum, Rosmarinus officinalis and Pelargonium asperum

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