A Review on the Role of Hypofractionated Radiotherapy in High-Grade Glioma Patients

Abstract

High-grade gliomas (HGG) comprise WHO grade III anaplastic astrocytoma (AA) and WHO grade IV glioblastoma (GBM). Even WHO grade II, IDH-wild type gliomas may be categorized as HGG since genetic abnormalities are predictive. Surgery, radiation therapy (RT), chemotherapy, and combinations thereof are currently used to treat HGG. Patients with GBM and low-performance status who are elderly (defined here as age 60 or more) do far worse in terms of survival than younger patients. Surgery and chemoradiation are the mainstays of care for treating HGG. The best course of treatment for old and/or underperforming individuals, who typically have worse prognoses, is still up for debate. Elderly individuals treated with radiation therapy (RT) have better survival rates than those receiving only the best supportive care (BSC), but patients receiving both conventional RT and hypofractionated RT have equal survival rates.