A review on the role of salivary MUC5B in oral health

Faruque, Mouri R. J.; Wanschers, Melène; Ligtenberg, A.J.M.; Laine, Marja L.; Bikker, Floris J.

doi:10.1016/j.job.2022.09.005

Cited by 22 publications

(8 citation statements)

References 79 publications

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“…For "drinking water" and "drinking small volumes" their high frequencies could be explained by the short working effects and lack of lubricating properties in contrast to saliva, which is contained with e.g. mucins, which aid in the retention of uids in the oral cavity [22,23]. Other frequently used interventions were "eating fruit", "moistening the lips" and "concentrating on other activities'' were found to be applied frequently.…”

Section: Discussionmentioning

confidence: 99%

Use and efficacy of dry-mouth interventions in Sjögren’s Disease patients and possible association with perceived oral dryness and patients’ discomfort

Assy,

Santen,

Brand

et al. 2023

Preprint

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Objectives Sjögren’s Disease (SjD) patients use various interventions to relief their oral dryness. However, the use and efficacy of these interventions have only partially been evaluated. The present study aims to investigate whether there is an association between the perceived oral dryness and discomfort of SJDpatients and their use of specific interventions.Materials and methods A cross-sectional study was performed among SjD patients, who completed several questionnaires to assess the severity of their oral dryness and an inventory of dry-mouth interventions. The perceived efficacy of each intervention was reported on a 5-point Likert-scale.Results The questionnaires were returned by 92 SjD patients. For relief of oral dryness, they mostly used “eating fruit’’, “drinking tea’’, “moistening the lips’’, “drinking water’’ and “drinking small volumes’’ (> 50%). Three interventions had a frequency of use ranging from 2–6 times/day, whereas, “drinking water’’ and “drinking small volumes’’ showed higher frequencies (> 14). The highest overall efficacy (≥ 3.5) was reported for “chewing gum’’ and “using a mouth gel’’. Furthermore, various dry-mouth interventions showed significant associations with oral dryness scores and/or patients’ discomfort. For example, “drinking small volumes” and “using XyliMelts” were associated with the Bother Index score.Conclusion Great variation was found in the use of dry-mouth interventions by the participants and the severity of the oral dryness and/or patients’ discomfort seemed to affect their choice of intervention. Notably, the mostly used interventions did not show the highest reported efficacy.Clinical relevance: These findings might help SjD patients and clinicians in their choice for effective dry-mouth interventions.

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Section: Discussionmentioning

confidence: 99%

Use and efficacy of dry-mouth interventions in Sjögren’s Disease patients and possible association with perceived oral dryness and patients’ discomfort

Assy,

Santen,

Brand

et al. 2023

Preprint

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“…Spinnbarkeit correlates positively with calcium concentrations in saliva and mucins MUC5B and MUC7 [21,22]. MUC5B is a large, multimeric salivary glycoprotein with a molecular mass of >10 4 kDa composed of a protein backbone and a high number of hydrophilic carbohydrate side chains forming filamentous watery polymer brushes [23,24]. MUC5B is part of the dental pellicle important for properties such as moistening, lubrication, viscoelasticity, and spinnbarkeit [20,25].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Correlation between Salivary Spinnbarkeit and Caries Scores

Faruque,

Taidouch,

Bikker

et al. 2024

Caries Res

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Introduction: In this study, the relationship between the spinnbarkeit, i.e., the stretchability of saliva, and dental caries was investigated. Methods: Dentistry students were divided into a group with more than 2 decayed, missed, and filled teeth (DMFT ≥2, n = 30) and caries-free group (DMFT = 0, n = 36). Results: Unstimulated saliva flow rate, pH, and spinnbarkeit were determined. Salivary spinnbarkeit was significantly lower in the caries-prone group compared to the caries-free group (5.4 ± 3.9 mm vs. 13.5 ± 7.6 mm, respectively, p < 0.001). Conclusion: This suggests that saliva with high spinnbarkeit protects better against dental caries.

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“…Oral diseases due to salivary hypofunction constitute a significant concern among individuals with Sjögren’s disease (SD) (previously referred to as Sjögren’s Syndrome), affecting their oral and overall quality of life. The dry mouth due to salivary hypofunction is a predisposing factor for caries, candidiasis, mucositis, tooth wear, erosion, and other soft tissue oral pathologies [ 1 , 2 ]. Therefore, severe dental caries and dental restoration treatments are common in this population [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Longevity of dental restorations in Sjogren’s disease patients using electronic dental and health record data

Gomez,

Wang,

Siddiqui

et al. 2024

BMC Oral Health

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Background Decreased salivary secretion is not only a risk factor for carious lesions in Sjögren’s disease (SD) but also an indicator of deterioration of teeth with every restorative replacement. This study determined the longevity of direct dental restorations placed in patients with SD using matched electronic dental record (EDR) and electronic health record (EHR) data. Methods We conducted a retrospective cohort study using EDR and EHR data of Indiana University School of Dentistry patients who have a SD diagnosis in their EHR. Treatment history of patients during 15 years with SD (cases) and their matched controls with at least one direct dental restoration were retrieved from the EDR. Descriptive statistics summarized the study population characteristics. Cox regression models with random effects analyzed differences between cases and controls for time to direct restoration failure. Further the model explored the effect of covariates such as age, sex, race, dental insurance, medical insurance, medical diagnosis, medication use, preventive dental visits per year, and the number of tooth surfaces on time to restoration failure. Results At least one completed direct restoration was present for 102 cases and 42 controls resulting in a cohort of 144 patients’ EDR and EHR data. The cases were distributed as 21 positives, 57 negatives, and 24 uncertain cases based on clinical findings. The average age was 56, about 93% were females, 54% were White, 74% had no dental insurance, 61% had public medical insurance, < 1 preventive dental visit per year, 94% used medications and 93% had a medical diagnosis that potentially causes dry mouth within the overall study cohort. About 529 direct dental restorations were present in cases with SD and 140 restorations in corresponding controls. Hazard ratios of 2.99 (1.48–6.03; p = 0.002) and 3.30 (1.49–7.31, p-value: 0.003) showed significantly decreased time to restoration failure among cases and positive for SD cases compared to controls, respectively. Except for the number of tooth surfaces, no other covariates had a significant influence on the survival time. Conclusion Considering the rapid failure of dental restorations, appropriate post-treatment assessment, management, and evaluation should be implemented while planning restorative dental procedures among cases with SD. Since survival time is decreased with an increase in the number of surfaces, guidelines for restorative procedures should be formulated specifically for patients with SD.

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A review on the role of salivary MUC5B in oral health

Cited by 22 publications

References 79 publications

Use and efficacy of dry-mouth interventions in Sjögren’s Disease patients and possible association with perceived oral dryness and patients’ discomfort

Use and efficacy of dry-mouth interventions in Sjögren’s Disease patients and possible association with perceived oral dryness and patients’ discomfort

Exploring the Correlation between Salivary Spinnbarkeit and Caries Scores

Longevity of dental restorations in Sjogren’s disease patients using electronic dental and health record data

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