A Review on the Sex Differences in Organ and System Pathology with Alcohol Drinking

Vatsalya, Vatsalya; Liaquat, Hammad; Ghosh, Kuldeep; Mokshagundam, Sri Prakash L.; McClain, Craig J.

doi:10.2174/1874473710666170125151410

Cited by 32 publications

(25 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is indicative that the results of the CR sub-group (of quetiapine treated patients) mostly reflected the trends in males. Previously publications support vulnerability in females with alcohol drinking and its neurological manifestations, 45 this has not been analyzed in this study due to very low numbers of females enrolled. There were a few dropouts during the course of the study and 4% to 5% of the total data points could not be included in this study due to missing values.…”

Section: Discussionmentioning

confidence: 93%

Interaction of Heavy Drinking Patterns and Depression Severity Predicts Efficacy of Quetiapine Fumarate XR in Lowering Alcohol Intake in Alcohol Use Disorder Patients

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Shared etiological pathways of dopamine and serotonin neurotransmission play a central role in heavy alcohol intake and exacerbation in the symptoms of depression. We investigated the treatment efficacy of Quetiapine fumarate extended release (XR) in lowering alcohol intake in alcohol use disorder (AUD) patients indicated by the shared alleviation of depression ratings and patterns of heavy drinking. Methods: Hundred and eight male and female heavy drinking AUD patients in the age range of 18 to 64 years. participated in a randomized clinical trial (RCT) to receive 12 weeks of quetiapine XR or placebo (N = 115). Participants were sub-grouped by the severity grading of depression using Montgomery-Asberg Depression Rating Scale (MADRS) (clinically relevant ⩾8 [CR], clinically non-relevant ⩽7 [CNR]) at baseline in both the groups. Drinking history and depression ratings were assessed at the patients’ visits. Results: Heavy drinking days (HDD) and total drinks (TD) were significantly fewer in CR patients at the treatment end. A true positive response in AUROC analysis supported the lowering of TD in CR patients. The number of drinking days (NDD) and average drinks per drinking day (AvgD) were lower in the CNR patients at treatment-end. Significant associations with increasing effect sizes were observed for all the heavy drinking measures (HDD, TD, NDD, and AvgD) and MADRS scores by the end of the treatment course. Conclusions: Baseline elevated depressive symptoms could likely predict the course of heavy alcohol drinking during the treatment, and efficacy outcome of a treatment. AUD patients with baseline clinically significant depression had a progressive lowering in heavy drinking markers significantly corresponding to the lowering of depression symptoms by the end of treatment with Quetiapine fumarate XR. ClinicalTrials.gov: NCT#0049862 ( https://clinicaltrials.gov/ct2/show/NCT00498628?term=litten&draw=2&rank=3 )

show abstract

Section: Discussionmentioning

confidence: 93%

Interaction of Heavy Drinking Patterns and Depression Severity Predicts Efficacy of Quetiapine Fumarate XR in Lowering Alcohol Intake in Alcohol Use Disorder Patients

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Additional research is needed to determine whether unadjusted confounding factors may have contributed to this finding (Naimi et al., ), a possibility made more salient by the fact that failure to ever drink regularly was rare among men in Western New York State, whereas failure to drink regularly was more normative among women and not associated with increased AMI risk. Alternatively, given women's greater sensitivity to the effects of alcohol on health (Vatsalya et al., ), regular drinking may be less protective against AMI among women than among men.…”

Section: Discussionmentioning

confidence: 99%

Lifetime Drinking Trajectories and Nonfatal Acute Myocardial Infarction

Russell

Fan

Freudenheim

et al. 2019

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Background: The relation of lifetime drinking trajectories to coronary heart disease is not well understood.Methods: Cases hospitalized for a nonfatal acute myocardial infarction (AMI) and healthy population-based controls matched on age and sex completed a physical examination and an interview covering known AMI risk factors and a detailed lifetime drinking history. Distinct lifetime drinking trajectories based on ounces of ethanol consumed per decade between ages 10 and 59 years were derived and characterized according to lifetime drinking patterns associated with each. Sex-specific multiple logistic regression analyses were conducted to estimate AMI risk among participants who never drank regularly compared to lifetime drinking trajectories and risk associated with distinct trajectories among former and current drinkers.Results: Two lifetime drinking trajectories were derived, early peak and stable. Early peak trajectories were characterized by earlier onset of regular drinking, less frequent drinking, more drinks per drinking day, fewer total drinks, more frequent drunkenness per drinking year, and reduced alcohol intake or abstention by middle age. Never drinking regularly, reported by significantly more women than men, was associated with significantly higher AMI risk than stable lifetime drinking trajectories among men and in the sex-combined analysis of former drinkers only. Compared to stable lifetime drinking trajectories, early peak trajectories were associated with significantly higher AMI risk among male former drinkers, among sex-combined former drinkers, and among female current drinkers.Conclusions: Epidemiological studies of alcohol and health in populations over age 35 may have underestimated the impact of heavy episodic drinking during adolescence and emerging adulthood on the cardiovascular system.

show abstract

“…However, in women, the volumes continued to decline with sobriety, even after statistically accounting for age. This might indicate an AUD-related abnormality in another biological system, as AUDw may be more susceptible to liver injury and heart disease, and have been reported to display lower drinking thresholds for systemic damage [78].…”

Section: Influence Of Participant Characteristicsmentioning

confidence: 97%

Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder

et al. 2020

View full text Add to dashboard Cite

Alcohol Use Disorder (AUD) has been associated with abnormalities in hippocampal volumes, but these relationships have not been fully explored with respect to sub-regional volumes, nor in association with individual characteristics such as age, gender differences, drinking history, and memory. The present study examined the impact of those variables in relation to hippocampal subfield volumes in abstinent men and women with a history of AUD. Using Magnetic Resonance Imaging at 3 Tesla, we obtained brain images from 67 participants with AUD (31 women) and 64 nonalcoholic control (NC) participants (31 women). The average duration of the most recent period of sobriety for AUD participants was 7.1 years. We used Freesurfer 6.0 to segment the hippocampus into 12 regions. These were imputed into statistical models to examine the relationships of brain volume with AUD group, age, gender, memory, and drinking history. Interactions with gender and age were of particular interest. Compared to the NC group, the AUD group had approximately 5% smaller subiculum, CA1, molecular layer, and hippocampal tail regions. Age was negatively associated with volumes for the AUD group in the subiculum and the hippocampal tail, but no significant interactions with gender were identified. The relationships for delayed and immediate memory with hippocampal tail volume differed for AUD and NC groups: Higher scores on tests of immediate and delayed memory were associated with smaller volumes in the AUD group, but larger volumes in the NC group. Length of sobriety was associated with decreasing CA1 volume in women (0.19% per year) and increasing volume size in men (0.38% per year). The course of abstinence on CA1 volume differed for men and women, and the differential relationships of subfield volumes to age and memory could indicate a distinction in the impact of AUD on functions of the hippocampal tail. These findings confirm and extend evidence that AUD, age, gender, memory, and abstinence differentially impact volumes of component parts of the hippocampus.

show abstract

A Review on the Sex Differences in Organ and System Pathology with Alcohol Drinking

Cited by 32 publications

References 81 publications

Interaction of Heavy Drinking Patterns and Depression Severity Predicts Efficacy of Quetiapine Fumarate XR in Lowering Alcohol Intake in Alcohol Use Disorder Patients

Interaction of Heavy Drinking Patterns and Depression Severity Predicts Efficacy of Quetiapine Fumarate XR in Lowering Alcohol Intake in Alcohol Use Disorder Patients

Lifetime Drinking Trajectories and Nonfatal Acute Myocardial Infarction

Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder

Contact Info

Product

Resources

About