A Review on the Synthesis and Biological Studies of 2,4-Thiazolidinedione Derivatives

Abstract

: 2,4-Thiazolidinediones are a versatile scaffold with a unique structural feature of hydrogen bonding donor and the hydrogen bonding acceptor region. This review deals with the synthesis of various bio-active 2,4-thiazolidinedione derivatives. It is presented on the basis of the linker variations at 3rd & 5th positions of 2,4-thizolidinediones. Biological evaluations of various derivatives thus prepared and toxicity studies on the respective products as given by various researchers/ Research groups have been described.

Antifungal Thiazolidines: Synthesis and Biological Evaluation of Mycosidine Congeners

“…Thiazolidine and its derivatives, such as thiazolidine-2,4-dione (TZD) ( Figure 1 , structure II ), are important heterocyclic systems with a range of biological activities [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. According to the literature, TZD is one of the most important derivatives, due to a wide range of therapeutic effects and the possibility of modifications producing additional biological activities.…”