A review on therapeutic potentials of <i>Trigonella foenum graecum</i> (fenugreek) and its chemical constituents in neurological disorders: Complementary roles to its hypolipidemic, hypoglycemic, and antioxidant potential

Zameer, Saima; Najmi, Abul Kalam; Vohora, Divya; Akhtar, Mohd

doi:10.1080/1028415x.2017.1327200

Cited by 68 publications

(32 citation statements)

References 45 publications

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“…The extract exerted a significant (P < 0.05) hypoglycaemic effect in normal rabbits which was however short-lived. The hypoglycaemic effect was not significant (P > 0.1) in alloxan-treated rabbits [150] Fenugreek is an excellent source of neutral detergent fiber, proteins, vitamins as well as chemical constituents [172][173][174][175][176]. Hypoglycaemic activity of alcoholic extract of seeds of Trigonella foenum-graecum was tested in both normal and alloxan-induced diabetic rats.…”

Section: Pharmacological and Toxicological Studiesmentioning

confidence: 99%

Ethnopharmacological review of medicinal plants used to manage diabetes in Morocco

2020

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Diabetes is a chronic metabolic disorder which affects millions of people every year. If diabetes is not controlled, it can cause serious damage and a number of health complications. The aim of this paper was to review published ethnobotanical and ethnopharmacological evidences of Moroccan plants with antidiabetic potentials. Publications describing the medicinal plants used for the treatment of diabetes in Morocco were searched from the databases, including Google Scholar, Elsevier, Medline, Web of Science, SCOPUS and Pubmed. Other literature source was also used including books and theses available in library. About 750 literature references were studied, and only 240 research publications based on data from different Moroccan provinces published until June 2019 were included in this review. In total, 255 plants species belonging to 70 families were reported. Compositae and Lamiaceae were mentioned as the most represented families. The frequently used plant species in the dwellers of most regions of Morocco are Trigonella foenum-graecum, Artemesia herba-alba, Nigella sativa, Olea europaea, Allium cepa and Marrubium vulgare. This review provides useful information and current scientific knowledge on the medicinal plants used to manage diabetes in Morocco. Medicinal plants reported should be submitted to chemical, pharmacological and clinical studies to identify pharmacologically active metabolites and to confirm their antidiabetic activity.

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Section: Pharmacological and Toxicological Studiesmentioning

confidence: 99%

Ethnopharmacological review of medicinal plants used to manage diabetes in Morocco

2020

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“…Epidemiological studies have shown that people with Obesity and T2DM who received a chronic treatment with antioxidants or anti‐inflammatories, besides showing a greater sensitivity to insulin and low glucose levels, are also at low risk for developing cognitive damage or AD (Walker & Harrison, ). Furthermore, in animal models with hyperglycemia, there are benefits in glucose metabolism at the peripheral level, a decrease in hyperphosphorylation of the tau protein, reduction in the death of neurons, and an improvement in the processes of learning and memory (Lu et al, ; Zameer, Najmi, Vohora, & Akhtar, ). This clearly demonstrates the neuroprotective power of these anti‐inflammatory and anti‐inflammatory agents.…”

Section: Alzheimer Diseasementioning

confidence: 99%

Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration

Rojas-Gutierrez

Muñoz-Arenas

Treviño

et al. 2017

Synapse

149

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Alzheimer's disease (AD) is the most common cause of dementia and one of the most important causes of morbidity and mortality among the aging population. AD diagnosis is made post-mortem, and the two pathologic hallmarks, particularly evident in the end stages of the illness, are amyloid plaques and neurofibrillary tangles. Currently, there is no curative treatment for AD. Additionally, there is a strong relation between oxidative stress, metabolic syndrome, and AD. The high levels of circulating lipids and glucose imbalances amplify lipid peroxidation that gradually diminishes the antioxidant systems, causing high levels of oxidative metabolism that affects cell structure, leading to neuronal damage. Accumulating evidence suggests that AD is closely related to a dysfunction of both insulin signaling and glucose metabolism in the brain, leading to an insulin-resistant brain state. Four drugs are currently used for this pathology: Three FDA-approved cholinesterase inhibitors and one NMDA receptor antagonist. However, wide varieties of antioxidants are promissory to delay or prevent the symptoms of AD and may help in treating the disease. Therefore, therapeutic efforts to achieve attenuation of oxidative stress could be beneficial in AD treatment, attenuating Aβ-induced neurotoxicity and improve neurological outcomes in AD. The term inflammaging characterizes a widely accepted paradigm that aging is accompanied by a low-grade chronic up-regulation of certain pro-inflammatory responses in the absence of overt infection, and is a highly significant risk factor for both morbidity and mortality in the elderly.

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“…To our knowledge, no dietary pattern similar to Traditional-Indian-Confinement pattern has been examined in relation to PPD in previous literature for direct comparison. However, key food groups of Traditional-Indian-Confinement diet, such as Indian herbs and seed herbs (e.g., saffron [ 48 , 49 ], fenugreek [ 50 ]), as well as curcumin [ 51 , 52 ] present in curry dishes have previously been reported to be effective in alleviating depressive symptoms via their anti-inflammatory [ 49 , 53 ], neuroprotective [ 54 ], serotonergic [ 55 , 56 ], and hypothalamic pituitary adrenal (HPA) regulation effects [ 57 ]. The Traditional-Indian-Confinement diet also comprises of legumes and pulses and ethnic bread (e.g., chapatti, thosai, idli, and naan), which are rich in B-group vitamins, are crucial for the synthesis of monoamine neurotransmitters and may have helped to establish protection against PPD symptoms [ 20 , 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

Prospective Associations of Maternal Dietary Patterns and Postpartum Mental Health in a Multi-Ethnic Asian Cohort: The Growing up in Singapore towards Healthy Outcomes (GUSTO) Study

et al. 2018

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Diet in the first month postpartum, otherwise known as “the confinement diet” in Asia, has unique characteristics that are influenced by traditions, cultures, and beliefs. We aimed to characterize dietary patterns during confinement period in a multi-ethnic Asian cohort and examined their associations with postpartum depression (PPD) and anxiety (PPA). Dietary intakes of 490 women were ascertained in the first month postpartum using 3-day food diaries and dietary patterns were derived by factor analysis. Participants completed the Edinburgh Postnatal Depression Scale (EPDS) and State-Trait Anxiety Inventory (STAI) at three months’ postpartum; higher scores are indicative of more depressive and anxiety symptoms, respectively. Four dietary patterns were identified: Traditional-Chinese-Confinement diet, Traditional-Indian-Confinement diet, Eat-Out diet and Soup-Vegetables-Fruits diet. The Traditional-Indian-Confinement diet was associated with less PPD symptoms [β (95% CI) −0.62 (−1.16, −0.09) EPDS score per SD increase in diet score] and a non-significant trend with reduced probable PPD (EPDS scores ≥ 13) [OR (95% CI) 0.56 (0.31, 1.01)]. The Soup-Vegetables-Fruits diet was associated with less PPA symptoms [β (95% CI) −1.49 (−2.56, −0.42) STAI-state score]. No associations were observed for other dietary patterns. Independent of ethnicity, adherence to the Traditional-Indian-Confinement diet that is characterized by intake of herbs and legumes, and Soup-Vegetables-Fruits diet high in fruits, vegetables and fish during the postpartum period were associated with less PPD and PPA symptoms, respectively.

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A review on therapeutic potentials of Trigonella foenum graecum (fenugreek) and its chemical constituents in neurological disorders: Complementary roles to its hypolipidemic, hypoglycemic, and antioxidant potential

Cited by 68 publications

References 45 publications

Ethnopharmacological review of medicinal plants used to manage diabetes in Morocco

Ethnopharmacological review of medicinal plants used to manage diabetes in Morocco

Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration

Prospective Associations of Maternal Dietary Patterns and Postpartum Mental Health in a Multi-Ethnic Asian Cohort: The Growing up in Singapore towards Healthy Outcomes (GUSTO) Study

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