A review on therapeutical potential of paeonol in atherosclerosis

Yu, Wei; Ilyas, Iqra; Aktar, Nasrin; Xu, Suowen

doi:10.3389/fphar.2022.950337

Cited by 13 publications

(8 citation statements)

References 165 publications

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“…For more information on Sect. Moutan, please refer to the reference ( 10 ). Specifically, the PLP first appeared in written records in the earliest Chinese pharmacological work<神农本草经> (Shen nong Ben Cao Jing) in Eastern Han Dynasty, 25-220 AD.…”

Section: Paeoniflorinmentioning

confidence: 99%

“…The discovery of new drugs from natural products has become a new approach to discovering the treatment of CVD including atherosclerosis. Some extracts or single units of natural drugs have shown enormous potential for the therapy of atherosclerosis, such as paeonol ( 10 ). As an ornamental and medicinal plant widely distributed around the world, P. lactiflora is receiving increasing attention in the research and development of natural drugs.…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

Ilyas

et al. 2022

Front. Immunol.

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Epidemiological studies have shown that the incidence, prevalence and mortality of atherosclerotic cardiovascular disease (ASCVD) are increasing globally. Atherosclerosis is characterized as a chronic inflammatory disease which involves inflammation and immune dysfunction. P. lactiflora Pall. is a plant origin traditional medicine that has been widely used for the treatment of various diseases for more than a millennium in China, Japan and Korean. Paeoniflorin is a bioactive monomer extracted from P. lactiflora Pall. with anti-atherosclerosis effects. In this article, we comprehensively reviewed the potential therapeutic effects and molecular mechanism whereby paeoniflorin protects against atherosclerosis from the unique angle of inflammation and immune-related pathway dysfunction in vascular endothelial cells, smooth muscle cells, monocytes, macrophages, platelets and mast cells. Paeoniflorin, with multiple protective effects in atherosclerosis, has the potential to be used as a promising therapeutic agent for the treatment of atherosclerosis and its complications. We conclude with a detailed discussion of the challenges and future perspective of paeoniflorin in translational cardiovascular medicine.

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Section: Paeoniflorinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

Ilyas

et al. 2022

Front. Immunol.

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“…[15] MC possesses a range of pharmacological activities, including anticoagulant, anti-inflammatory, anti-tumour, and improvement in diabetes mellitus, among others. [15][16][17][18][19][20] However, MC is less used in agriculture, especially for fungicidal activity. Interestingly, our group discovered in a previous study that MC ethanol extract exhibited fungicidal activity against a wide range of plant pathogenic fungi, especially against R. solani, with 100 % inhibitory activity at a concentration of 1000 μg/mL.…”

Section: Introductionmentioning

confidence: 99%

“…Moutan cortex (MC), derived from the root bark of Paeonia suffruticosa Andrews, has been utilized in China's clinical practice for nearly 2000 years [15] . MC possesses a range of pharmacological activities, including anticoagulant, anti–inflammatory, anti–tumour, and improvement in diabetes mellitus, among others [15–20] . However, MC is less used in agriculture, especially for fungicidal activity.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Activity Against Rhizoctonia Solani and Chemical Composition of Extract from Moutan Cortex

Zhao,

Wang,

Han

et al. 2024

Chemistry & Biodiversity

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Rice sheath blight (RSB), caused by Rhizoctonia solani, is a significant disease of rice. The negative effects of chemical fungicides have created an urgent need for low‐toxicity botanical fungicides. Our previous research revealed that the ethanol crude extract of Moutan Cortex (MC) exhibited superior antifungal activity against R. solani at 1000 μg/mL, resulting in 100% inhibition rate. And the antifungal properties were mainly found in the petroleum ether extract. However, the active ingredients of the extract are still unclear. In this study, gas chromatography‐mass spectrometry (GC‐MS) was utilised for the analysis of its chemical components. The mycelium growth rate method was utilized to detect the antifungal activity. The findings indicated that paeonol constituted the primary active component, with a content of more than 96%. Meanwhile, paeonol was the most important antifungal active ingredient, the antifungal activity of paeonol (EC50 = 44.83 μg/mL) was much higher than that of β‐sitosterol and ethyl propionate against R. solani. Observation under an optical microscope revealed that paeonol resulted in abnormal mycelial morphology. This study provided theoretical support for identifying monomer antifungal compounds and developing biological fungicides for R. solani.

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“…However, Guizhi Fuling Decoction, as a classical formula, has complex and unclear composition. Paeonol in Guizhi Fuling Decoction was found to improve disease by regulating inflammation, platelet aggregation, lipid metabolism, mitochondrial damage, and endoplasmic reticulum autophagy [ 20 , 21 ]. Peng Yi et al investigated the mechanism by which paeonol alleviates dysmenorrhea in mice and found that paeonol reduces inflammatory cytokines and simultaneously inhibits uterine contractions [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

UPLC-Q-TOF/MS Based Plasma Metabolomics for Identification of Paeonol’s Metabolic Target in Endometriosis

et al. 2023

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Endometriosis is a common gynecological illness in women of reproductive age that significantly decreases life quality and fertility. Paeonol has been shown to play an important part in endometriosis treatments. Understanding the mechanism is critical for treating endometriosis. In this study, autologous transplantation combined with a 28 day ice water bath was used to create a rat model of endometriosis with cold clotting and blood stagnation. The levels of estradiol and progesterone in plasma were detected by ELISA, and the pathological changes of ectopic endometrial tissue were examined by H&E staining, which proved the efficacy of paeonol. For metabolomic analysis of plasma samples, UPLC-Q/TOF-MS was combined with multivariate statistical analysis to identify the influence of paeonol on small molecule metabolites relevant to endometriosis. Finally, the key targets were screened using a combination of network pharmacology and molecular docking approaches. The results showed that the pathological indexes of rats were improved and returned to normal levels after treatment with paeonol, which was the basis for confirming the efficacy of paeonol. Metabolomics results identified 13 potential biomarkers, and paeonol callbacks 7 of them, involving six metabolic pathways. Finally, four key genes were found for paeonol therapy of endometriosis, and the results of molecular docking revealed a significant interaction between paeonol and the four key genes. This study was successful in establishing a rat model of endometriosis with cold coagulation and blood stagnation. GCH1, RPL8, PKLR, and MAOA were the key targets of paeonol in the treatment of endometriosis. It is also demonstrated that metabolomic techniques give the potential and environment for comprehensively understanding drug onset processes.

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A review on therapeutical potential of paeonol in atherosclerosis

Cited by 13 publications

References 165 publications

Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

Inhibitory Activity Against Rhizoctonia Solani and Chemical Composition of Extract from Moutan Cortex

UPLC-Q-TOF/MS Based Plasma Metabolomics for Identification of Paeonol’s Metabolic Target in Endometriosis

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