2020
DOI: 10.30526/33.2.2442
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A Review: Saccharin Discovery, Synthesis, and Applications

Abstract: Saccharin is firstly synthesized in 1879. It is a very well-known as an inexpensive substitute for sugar as it is a non-caloric sweetener. The article shows the properties, use, metabolism and various synthesis and reactions of saccharine. Moreover, the toxicological reports explain that saccharin is mostly responsible for the bladder tumors observed in the male rats, the relationship between the consumption of saccharin and bladder cancer is afforded by epidemiological studies.  The benefit-risk evaluation fo… Show more

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Cited by 12 publications
(10 citation statements)
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“…The sodium saccharin was rejected due to its intensely sweet and the off bitter flavour provided by it in the product prepared. The bitter flavour by incorporation of sodium saccharin in milk products during high thermal treatment has been reported by Mahmood and Al-Juboori (2020). The bulking agents viz., maltodextrin, and D-sorbitol as filler were tried in (1:1) ratio at different levels, viz., 4, 5, 6, and 7 %.…”
Section: Preliminary Studymentioning
confidence: 97%
“…The sodium saccharin was rejected due to its intensely sweet and the off bitter flavour provided by it in the product prepared. The bitter flavour by incorporation of sodium saccharin in milk products during high thermal treatment has been reported by Mahmood and Al-Juboori (2020). The bulking agents viz., maltodextrin, and D-sorbitol as filler were tried in (1:1) ratio at different levels, viz., 4, 5, 6, and 7 %.…”
Section: Preliminary Studymentioning
confidence: 97%
“…As shown previously [15], OLZ benefits from co-amorphization with saccharin (SAC, pKa = 1.6 [16], Figure 1B), both in terms of solubility (5896 vs. 41 mg/L for OLZ-CAM and pure crystalline OLZ, respectively) and dissolution rate of the drug (88.7 vs. 25.2% of drug release for OLZ-CAM and pure crystalline OLZ, respectively). Both olanzapine [17] and saccharine [18] are reportedly stable under the conditions used for co-amorphization [15]. The formation of a stable CAM between OLZ and SAC was explained by salification, rather than hydrogen or π-π bonds, which was supported by the huge difference between the pKa of OLZ and SAC (∆pKa = 6.06) [15].…”
Section: Introductionmentioning
confidence: 98%
“…Schiff-base formation from the reaction of tryptophan and saccharin ( Mahmood and AlJuboori, 2020 ).…”
Section: Introductionmentioning
confidence: 99%