A Review Study on Macrolides Isolated from Cyanobacteria

Wang, Mengchuan; Zhang, Jinrong; He, Shan; Yan, Xiaojun

doi:10.3390/md15050126

Cited by 38 publications

(27 citation statements)

References 59 publications

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“…These unique organisms produce as secondary metabolites a number of biologically active substances with antifungal, antibacterial, antitumor, immunosuppressive, immunostimulating and toxic effects [7][8][9]. This determined their high potential as sources of substances used in the food and pharmaceutical industries, medicine and biotechnology.…”

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confidence: 99%

Content of phycoerythrin, phycocyanin, alophycocyanin and phycoerythrocyanin in some cyanobacterial strains: Applications

Basheva

Moten

Stoyanov

et al. 2018

Engineering in Life Sciences

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Cyanobacteria are unique prokaryotes, which are capable to perform oxygenic photosynthesis. Within these organisms, phycobilisomes (PBS) act as an antenna of the photosynthetic pigment apparatus. Phycobilisomes contain several phycobiliproteins (PBP): phycoerythrin (PE), phycocyanin (PC), allophycocyanin (APC) and phycoerythrocyanin (PEC). The application of phycobiliproteins in the biotechnology, food industry and medicine during the last years is rapidly increasing. The aim of our study was to assess the qualitative and quantitative content of phycoerythrin, phycocyanin, allophycocyanin and phycoerythrocyanin in 14 cyanobacterial strains kept in Plovdiv Algal Culture Collection (PACC) and 4 strains purchased from the Culture Collection of Autotrophic Organisms (CCALA). Our data demonstrated that three strains of Microcoleus autumnalis (PACC 5505, PACC 5522 and PACC 5527) have high potential to produce phycoerythrins (0.132, 0.201 and 0.136 mg/mL, respectively). Similarly, one Microcoleus autumnalis strain (PACC 5522) and one strain of Leptolyngbya boryana (CCALA 084) are suitable for biotechnological production of phycocyanins (0.051 and 0.264 mg/mL, respectively) as well as allophycocyanins (0.102 and 0.171 mg/mL, respectively). In addition, the data about the pigment content could be used as a biochemical marker for taxonomic purposes within the group.

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confidence: 99%

Content of phycoerythrin, phycocyanin, alophycocyanin and phycoerythrocyanin in some cyanobacterial strains: Applications

Basheva

Moten

Stoyanov

et al. 2018

Engineering in Life Sciences

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“…Marine cyanobacteria are extraordinarily rich in biologically active and structurally diverse natural products (NPs), often times deriving from hybrid nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) biosynthetic pathways [1][2][3]. However, those cyanobacterial NPs with an exclusive PKS origin are often cyclized to form macrolides, a class of compounds that generally possesses important biomedical properties [4,5]. From other microbial sources, macrolide NPs have proven utility in treating human diseases, such as erythromycin and clarithromycin, as antibiotics, tacrolimus as a macrolide immunosuppressant, and amphotericin B and nystatin as antifungals.…”

Section: Introductionmentioning

confidence: 99%

Palstimolide A: A Complex Polyhydroxy Macrolide with Antiparasitic Activity

et al. 2020

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Marine Cyanobacteria (blue-green algae) have been shown to possess an enormous potential to produce structurally diverse natural products that exhibit a broad spectrum of potent biological activities, including cytotoxic, antifungal, antiparasitic, antiviral, and antibacterial activities. Here, we report the isolation and structure determination of palstimolide A, a complex polyhydroxy macrolide with a 40-membered ring that was isolated from a tropical marine cyanobacterium collected at Palmyra Atoll. NMR-guided fractionation in combination with MS2-based molecular networking and isolation via HPLC yielded 0.7 mg of the pure compound. The small quantity isolated along with the presence of significant signal degeneracy in both the 1H and 13C-NMR spectra complicated the structure elucidation of palstimolide A. Various NMR experiments and solvent systems were employed, including the LR-HSQMBC experiment that allows the detection of long-range 1H–13C correlation data across 4-, 5-, and even 6-bonds. This expanded NMR data set enabled the elucidation of the palstimolide’s planar structure, which is characterized by several 1,5-disposed hydroxy groups as well as a tert-butyl group. The compound showed potent antimalarial activity with an IC50 of 223 nM as well as interesting anti-leishmanial activity with an IC50 of 4.67 µM.

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“…Two main aspects, the chemical diversity and the related bioactivity, have to be considered when considering the application potential of natural products (molecules, metabolites, or compounds) produced by cyanobacteria. The chemical diversity of metabolites produced by cyanobacteria has been largely described and about fifteen reviews have been already published in the past twenty years dealing with their structural and chemical diversity [9][10][11][12][13][14] or their corresponding biosynthetic pathways [15,16]. Beyond the notorious harmful effects of cyanotoxins, other cyanobacterial natural products show a wide range of bioactivities that could be potentially useful for diverse application fields [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Natural Products from Cyanobacteria: Focus on Beneficial Activities

Demay

Bernard²,

Reinhardt

et al. 2019

Preprint

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Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities and the diversity of natural products (molecules, metabolites, or compounds) that they synthesize support the cyanobacterial success for the colonization of their respective ecological niches. Although cyanobacteria are well-known for their toxin production and their relative deleterious consequences, they also produce a large variety of molecules that exhibit beneficial properties with high potential for various fields of application (e.g., synthetic analog of the dolastatin 10 used against Hodgkin lymphoma). The present review specially focuses on the beneficial activities of cyanobacterial molecules described so far. Based on an analysis of 670 papers, it appears that more than 90 genera of cyanobacteria have been found to produce compounds with potential beneficial activities, most of them belonging to the orders Oscillatoriales, Nostocales Chroococcales, and Synechococcales. The rest of the cyanobacterial orders (i.e., Pleurocapsales, Chroococcidiopsales, and Gloeobacterales) remain poorly explored in terms of their molecular diversity and relative bioactivity. The diverse cyanobacterial molecules presenting beneficial bioactivities belong to 10 different chemical classes (alkaloids, depsipeptides, lipopeptides, macrolides/lactones, peptides, terpenes, polysaccharides, lipids, polyketides, and others) that exhibit 14 major kinds of bioactivity. However, no direct relation between the chemical class and the bioactivity of these molecules has been demonstrated. We further selected and specifically described 50 molecule families according to their specific bioactivities and their potential uses in pharmacology, cosmetology, agriculture, or other specific fields of interest. This up-to-date review takes advantage of the recent progresses in genome sequencing and biosynthetic pathway elucidation, and presents new perspectives for the rational discovery of new cyanobacterial metabolites with beneficial bioactivity.

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A Review Study on Macrolides Isolated from Cyanobacteria

Cited by 38 publications

References 59 publications

Content of phycoerythrin, phycocyanin, alophycocyanin and phycoerythrocyanin in some cyanobacterial strains: Applications

Content of phycoerythrin, phycocyanin, alophycocyanin and phycoerythrocyanin in some cyanobacterial strains: Applications

Palstimolide A: A Complex Polyhydroxy Macrolide with Antiparasitic Activity

Natural Products from Cyanobacteria: Focus on Beneficial Activities

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