Urban safety production is a core component of social safety and is associated with the production, storage and transport of hazardous chemicals, which are potential sources of disaster in an urban area. Chemicals’ locations in a city present a hidden site of danger, which can easily become disaster sites if supervision is inadequate. Aiming to improve the processes and typical scenarios of the production, storage, transportation and use of hazardous chemicals, this paper proposes an intelligent-technology-empowered active emergency command strategy (ITAECS) for urban hazardous chemical disaster management (UHCDM) in smart–safe cities. This paper aims to provide a strategy for active emergency command that takes into account the disaster source; hidden danger site; or disaster site of hazardous chemicals such as natural gas, gasoline and hydrogen energy based on five aspects: intelligent perception technology and equipment, a dynamically perceived IoT system, the accurate deduction of disaster posture, virtual reality emergency rescue rehearsal and an immersive emergency command platform. This research is conducive to the safety, efficiency and greenness of the whole industrial chain, such as the production, storage, transportation, operation and use of hazardous chemicals. There are difficulties and challenges in introducing ITAECS to urban hazardous chemical production safety and emergency management, such as the need for joint promotion of enterprises, industries and governments; uneven technological development; and several scientific–technological issues to be solved, as well as non-uniform standards. Overall, this paper helps improve the emergency management of urban hazardous chemical safety production.