A Revolution in Biomedical Assessment: The Development of Salivary Diagnostics

Tabak, Lawrence A.

doi:10.1002/j.0022-0337.2001.65.12.tb03492.x

Cited by 116 publications

(69 citation statements)

References 47 publications

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“…Leakage of blood and GCF into the oral cavity may compromise the measurement of salivary components (43). In order to estimate the level of contamination of the saliva samples by potential extraoral sources of IgA, the levels of transferrin were calculated for each sample.…”

Section: Transferrin Concentration In Saliva Samplesmentioning

confidence: 99%

Salivary IgA to cariogenic bacteria in HIV‐positive children and its correlation with caries prevalence and levels of cariogenic microorganisms

Castro

Souza

Lopes

et al. 2004

Oral Microbiology and Immunology

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The interrelationship of HIV infection, dental caries and mucosal immune responses remains controversial. In our study population of 40 HIV-infected and 40 healthy control children (ages 2-5 years) there was a significantly higher prevalence of dental caries in HIV-infected children (P<0.05). The extent of caries correlated with the severity of HIV disease. To determine whether the immunosuppression that ensues after HIV infection could contribute to the increased caries prevalence, the concentrations of total IgA and IgA specific to cariogenic bacteria (Streptococcus mutans, Streptococcus sobrinus and Lactobacillus acidophilus) were determined in whole saliva by enzyme-linked immunosorbent assay. Levels of the same bacteria were also quantified in saliva using checkerboard DNA-DNA hybridization. A significantly increased level of total salivary IgA was found in the HIV-positive population (P < 0.05), but there were comparable titers of specific IgA to cariogenic bacteria in HIV-positive and healthy controls. The microbiological assessment also demonstrated similar levels of cariogenic microorganisms in both groups. We conclude that HIV-positive children appear to maintain the capacity to mount a mucosal immune response to cariogenic microorganisms, at least until late stages of disease.

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Section: Transferrin Concentration In Saliva Samplesmentioning

confidence: 99%

Salivary IgA to cariogenic bacteria in HIV‐positive children and its correlation with caries prevalence and levels of cariogenic microorganisms

Castro

Souza

Lopes

et al. 2004

Oral Microbiology and Immunology

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“…Saliva analysis was chosen, since it is an attractive diagnostic fluid, especially with regard to children and disability patients. Furthermore, saliva collection is a noninvasive technique, painless, fast, and lower cost when compared to blood collection …”

Section: Introductionmentioning

confidence: 99%

Reduced salivary flow rate and high levels of oxidative stress in whole saliva of children with Down syndrome

Domingues

Mariusso

Tanaka

et al. 2017

Special Care in Dentistry

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“…It has been determined that a number of markers are present in saliva; therefore, its use as a diagnostic fluid could have significant diagnostic and logistical advantages when compared with serum. As a diagnostic medium, saliva has several advantages – its collection is safe, non‐invasive, inexpensive, and simple, and it may be collected repeatedly without discomfort to the patient (Tabak, 2001; Bigler et al , 2002; Kaufman and Lamster, 2002; Lawrence, 2002; Agha‐Hosseini et al , 2006). It is used to aid in the diagnosis of diseases and assessment of the severity of some illnesses (Agha‐Hosseini et al , 2007a,b).…”

Section: Introductionmentioning

confidence: 99%