A réz élettani funkciója, a rézfelhalmozódás és a rézhiány kóroktani szerepe

Vetlényi, Enikő; Rácz, Gergely

doi:10.1556/650.2020.31854

Cited by 19 publications

(9 citation statements)

References 44 publications

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“…Copper is an essential element, and it enters a lot of physiological functions, being a part of different enzymes and proteins. For example, copper is required for terminal oxidation and the elimination of free radicals and is involved in the synthesis of hormones and iron metabolism [ 36 ]. Both copper deficiency and poisoning, especially in ruminants, are responsible for nutritional and nutrition-related diseases and, in the case of livestock, for economic losses due to the mortality of animals.…”

Section: Discussionmentioning

confidence: 99%

Roe Deer (Capreolus capreolus) Hair as a Bioindicator for the Environmental Presence of Toxic and Trace Elements

Draghi

Agradi

Riva

et al. 2023

Toxics

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The return to pasture use as an alternative to intensive livestock farming implies some risks with the lack or the excessive presence of potentially toxic elements; in this regard, wild animals have been used as bioindicators for decades. Thus, the purpose of this study is quantifying Cu, Cr, Mn, Zn, Se, As, Cd, Ni, Pb, Al, Fe, and Mg in fur from roe deer and understanding if it is a valid bioindicator tool. Hair was collected from 39 hunted roe deer and divided by age (<36 months old/≥36 months old), sex (male/female), and area of origin (urbanized/rural area). The mean concentrations of Fe, Mg, Mn, Al, Cr, and Pb were higher (p < 0.05) in the urbanized group; the mean levels of Mg and Cr were higher (p < 0.05) in older animals; and Cu, Fe, Mg, Cd, and Cr showed a higher accumulation in females. Our findings showed an age-related variation of elements, with higher concentrations in adult animals and females. In conclusion, our findings prove that hair is a valid matrix for this type of survey, and wild animals are good bioindicators for monitoring the presence of trace elements in pastures.

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Section: Discussionmentioning

confidence: 99%

Roe Deer (Capreolus capreolus) Hair as a Bioindicator for the Environmental Presence of Toxic and Trace Elements

Draghi

Agradi

Riva

et al. 2023

Toxics

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“…Because of the dual role of metallic copper in tumor progression, this area is becoming a hot research topic in cancer biology. Copper is a valuable coenzyme in the metabolism of organisms (30), and the imbalance of copper ion homeostasis in the human body is also closely related to various diseases (31). Increasing evidence has shown that copper plays vital roles in tumor cell proliferation, angiogenesis, and cancer metastasis (32,33).…”

Section: Discussionmentioning

confidence: 99%

Prognostic analysis of cuproptosis-related gene in triple-negative breast cancer

Sha

et al. 2022

Front. Immunol.

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BackgroundCuproptosis is a copper-dependent cell death mechanism that is associated with tumor progression, prognosis, and immune response. However, the potential role of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) of triple-negative breast cancer (TNBC) remains unclear.Patients and methodsIn total, 346 TNBC samples were collected from The Cancer Genome Atlas database and three Gene Expression Omnibus datasets, and were classified using R software packages. The relationships between the different subgroups and clinical pathological characteristics, immune infiltration characteristics, and mutation status of the TME were examined. Finally, a nomogram and calibration curve were constructed to predict patient survival probability to improve the clinical applicability of the CRG_score.ResultsWe identified two CRG clusters with immune cell infiltration characteristics highly consistent with those of the immune-inflamed and immune-desert clusters. Furthermore, we demonstrated that the gene signature can be used to evaluate tumor immune cell infiltration, clinical features, and prognostic status. Low CRG_scores were characterized by high tumor mutation burden and immune activation, good survival probability, and more immunoreactivity to CTLA4, while high CRG_scores were characterized by the activation of stromal pathways and immunosuppression.ConclusionThis study revealed the potential effects of CRGs on the TME, clinicopathological features, and prognosis of TNBC. The CRGs were closely associated with the tumor immunity of TNBC and are a potential tool for predicting patient prognosis. Our data provide new directions for the development of novel drugs in the future.

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“…Copper homeostasis is important in the proper functioning of various physical and biological processes. Copper homeostasis imbalance is closely correlated with various diseases 26 . Evidence from previous studies has demonstrated that copper is critical in tumor cell proliferation, angiogenesis, and metastasis 27 .…”

Section: Discussionmentioning

confidence: 99%

Cuproptosis-related risk score based on machine learning algorithm predicts prognosis and characterizes tumor microenvironment in head and neck squamous carcinomas

Zhang

et al. 2023

Sci Rep

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Cuproptosis is a recently discovered type of programmed cell death that shows significant potential in the diagnosis and treatment of cancer. It has important significance in the prognosis of HSNC. This study aims to construct a cuproptosis-related prognostic model and risk score through new data analysis methods such as machine learning algorithms for the prognosis analysis of HSNC. Protein–protein interaction network and machine learning methods were employed to identify hub genes that were used to construct a TreeGradientBoosting model for predicting overall survival. The relationship between the risk scores obtained from the model and features such as tumor microenvironment (TME) and tumor immunity was explored. The C-indexes of the TreeGradientBoosting model in the training and validation cohorts were 0.776 and 0.848, respectively. The nomogram based on risk scores and clinical features showed good performance, and distinguished the TME and immunity between high-risk and low-risk groups. The cuproptosis-associated risk score can be used to predict prognoses, TME, and tumor immunity of HNSC patients.

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A réz élettani funkciója, a rézfelhalmozódás és a rézhiány kóroktani szerepe

Cited by 19 publications

References 44 publications

Roe Deer (Capreolus capreolus) Hair as a Bioindicator for the Environmental Presence of Toxic and Trace Elements

Roe Deer (Capreolus capreolus) Hair as a Bioindicator for the Environmental Presence of Toxic and Trace Elements

Prognostic analysis of cuproptosis-related gene in triple-negative breast cancer

Cuproptosis-related risk score based on machine learning algorithm predicts prognosis and characterizes tumor microenvironment in head and neck squamous carcinomas

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