A rickettsia infection from Saudi Arabia

Elzein, Fatehi; Aloteibi, Mutib; Alanazi, Wasan Lafi; Alsaeed, Mohammed; Almaghaslah, Manar

doi:10.1016/j.ijid.2019.10.042

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…5). By the end of the first week, the rash develop into a maculopapular rash with central petechiae (CDC 2000;Regan et al 2015;Lindblom 2016;Elzein et al 2020). In RMSF, a skin rash may be not obvious in patients with dark skin (Kirkland et al 1995;Rathi and Rathi 2010).…”

Section: Clinical Symptoms Of Rmsfmentioning

confidence: 99%

Rocky Mountain Spotted Fever

2023

IJAB

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Section: Clinical Symptoms Of Rmsfmentioning

confidence: 99%

Rocky Mountain Spotted Fever

2023

IJAB

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“…Acute neurological manifestations of rickettsial diseases include severe headache, behavioral abnormalities, meningismus, photophobia, amnesia, aphasia, visual and hearing loss, ataxia, seizures, encephalitis, and coma (reviewed in [9]). These symptoms are most often reported in children and patients with delayed diagnosis [10,11]. Infection and associated neuroinflammation may be fatal [12] or lead to lasting sequelae [13,14].…”

Section: Introductionmentioning

confidence: 99%

Rickettsia Deregulates Genes Coding for the Neurotoxic Cell Response Pathways in Cerebrocortical Neurons In Vitro

Cente

Danchenko

Škultéty

et al. 2023

Cells

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Rickettsial infections of the central nervous system (CNS) are manifested by severe neurological symptoms and represent a serious life-threatening condition. Despite the considerable health danger, only a few studies have been conducted focusing on the pathogenesis induced by Rickettsia sp. in CNS. To investigate the signaling pathways associated with the neurotoxic effects of rickettsiae, we employed an experimental model of cerebrocortical neurons combined with molecular profiling and comprehensive bioinformatic analysis. The cytopathic effect induced by Rickettsia akari and Rickettsia slovaca was demonstrated by decreased neuronal viability, structural changes in cell morphology, and extensive fragmentation of neurites in vitro. Targeted profiling revealed the deregulation of genes involved in the neuroinflammatory and neurotoxic cell response pathways. Although quantitative analysis showed differences in gene expression response, functional annotation revealed that the biological processes are largely shared between both Rickettsia species. The identified enriched pathways are associated with cytokine signaling, chemotaxis of immune cells, responses to infectious agents, interactions between neurons, endothelial and glial cells, and regulation of neuronal apoptotic processes. The findings of our study provide new insight into the etiopathogenesis of CNS infection and further expand the understanding of molecular signaling associated with neuroinvasive Rickettsia species.

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