Developing a just‐in‐time (JIT) compiler can be a daunting task, especially for a language as flexible as Python. While PyPy, powered with JIT compilation, can often outperform the official pure interpreter, CPython, by a noteworthy margin, its popularity remains far from comparable to that of CPython due to some issues. Given that an easier‐to‐deploy and better‐compatible JIT compiler would benefit more Python users, we have developed comPyler, a simple JIT compiler functioning as a CPython extension and intended to convert frequently interpreted CPython bytecode into equivalent machine code. Designed with good compatibility in mind, it does not alter CPython's internal data structures or external interfaces. Based on LLVM's mature infrastructure, it can be readily ported to almost all platforms. Compared with CPython, it achieved the highest speedup of 2.205, with an average of 1.093. Despite its relatively limited effect, comPyler incurs low development costs. As a baseline compiler, it also sheds light on the improvement attainable by optimizing solely the overhead of bytecode interpretation. Furthermore, as there is still a dearth of empirical research covering the multitude of JIT compilers available for Python, we have conducted a performance study that examines Jython, IronPython, PyPy, GraalPy, Pyston, Pyjion, and our comPyler. Our research takes into account not only the benchmark speed for various time windows but also the boot latency and memory footprint. Through this comprehensive study, our objective is to assist developers in gaining a better understanding of the effects of distinct JIT compilation techniques and to aid users in making informed decisions when choosing among different Python implementations.