A Risk-Benefit Assessment of Drugs Used in the Eradication of Helicobacter pylori Infection

Abstract

Helicobacter pylori is the cause of chronic active gastritis and predisposes to peptic ulcer disease (PUD). Furthermore, H. pylori is linked to the pathogenesis of gastric lymphoma and gastric cancer. However, treatment of this infection has proven difficult. In the last decade, many antimicrobial compounds have been studied extensively as monotherapy as well as in combination with bismuth or acid-suppressive drugs. The individual drugs and the most important eradication regimens are discussed with special regard to their risks. In the past, highly complex multidrug regimens, fear of adverse effects and frequent eradication failures have hampered the broad acceptance of H. pylori-eradication therapies. Recently, new 1-week, low-dose combination regimens of 2 antibacterials with a proton pump inhibitor have consistently achieved eradication rates of 90% and more with an acceptably low rate of adverse effects. One week's standard triple therapy [tripotassium dicitrato bismuthate (or bismuth salicylate plus metronidazole plus tetracycline or amoxicillin) has been shown to be highly effective and tolerated better in combination with a proton pump inhibitor. This regimen is, however, more complex and has more adverse effects. Therefore, it is not recommended as first-line therapy. Equipped with these therapies physicians can now be strongly encouraged to use H. pylori eradication as the therapy of choice for patients with PUD and even extend this treatment to other H. pylori-associated disease conditions.

Helicobacter pylori infection and peptic ulcer disease

“…Historically, the first substances in use were bismuth salts (bismuth subcitrate and bismuth sub salicylate) [66], followed by several antibiotics among the 5-nitroimidazoles, penicillins and chinolones. Antibacterial monotherapy was ineffective in the eradication of H. pylori, since such regimes typically achieved cure rates of < 20 % after 2 to 4 weeks of therapy [67]. Use of mono therapy with antibiotics was eventually strongly discouraged due to the possible risk of development of antibacterial resistance [66].…”

Helicobacter pylori Current Chemotherapy and New Targets for Drug Design

“…31,150].Unfortunately, there is no gold standard therapy that is 100% effective for the eradication of all H. pylori infections. Nevertheless, today's antibiotic…”

Ökonomische Aspekte der Helicobacter-pylori-Eradikation - Eine Standortbestimmung

“…Diese divergierenden Ergebnisse beruhen zum gröûten Teil darauf, dass sehr heterogene Regime bis Mitte der 90er Jahre zur Anwendung kamen, allerdings spielten auch die Güte der Erfolgsevaluation und z. B. die Resistenzlage unabhängig von anderen populationsbedingten Faktoren und Nebenwirkungen eine Rolle [5].…”