A risk factor for newly diagnosed secondary cancer in patients with early-stage laryngeal, oropharyngeal, or hypopharyngeal cancer: sub-analysis of a prospective observation study

Nishimura, Goshi; Sano, Daisuke; Arai, Yasuhiro; Takahashi, Hideaki; Hatano, Takashi; Kitani, Yosuke; Takada, Kazuya; Wada, Takashi; Hiiragi, Yohei

doi:10.1007/s10147-021-02080-x

Cited by 2 publications

(2 citation statements)

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“…Recently, developments in medical technology have increased the chances of detecting head and neck cancer at an early-stage and have enabled a long-term prognosis. We have previously reported that early-stage laryngeal, oropharyngeal, and hypopharyngeal cancer patients who were treated with TOS showed a good prognosis, even though a high rate of secondary carcinogenesis occurred 8,9) . Among these cancers, hypopharyngeal cancer was found to be an independent risk factor for secondary carcinogenesis, and although associations with alcohol consumption, smoking, and aging were inferred, no direct relationship could be demonstrated.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously reported that patients with early-stage laryngeal, oropharyngeal, and hypopharyngeal cancer treated by transoral surgery (TOS) had a high incidence rate of newly diagnosed secondary cancer during the observation period after TOS 8,9) . In these patients, the primary site of the hypopharynx was an independent risk factor for secondary cancer.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors of secondary cancer in laryngeal, oropharyngeal, or hypopharyngeal cancer after definitive therapy

Nishimura,

Takahashi,

Sano

et al. 2023

Int J Clin Oncol

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BackgroundOur previous research showed that a high rate of secondary carcinogenesis is observed during follow-up after transoral surgery in patients with early-stage laryngeal, oropharyngeal, and hypopharyngeal cancers.We speculate that the contributing factors are alcohol drinking, smoking, and aging; however, we could not provide clear evidence. In this study, we aimed to identify the risk factors for secondary carcinogenesis in patients with these cancers, particularly factors associated with drinking and/or smoking. MethodsThe medical records of all-stage laryngeal, oropharyngeal, and hypopharyngeal cancer patients who had undergone de nitive treatment were retrospectively analyzed. Assessments included visual and endoscopic observations of the primary site, enhanced cervical CT or US of the primary site and regional lymph nodes, PET-CT, and enhanced whole-body CT. Clinical characteristics were compared in patients with and without secondary carcinogenesis and in patients with hypopharyngeal cancer and patients with other cancers. ResultsHypopharyngeal cancer was an independent risk factor for secondary cancer. The 5-year incidence rate of secondary cancer was 25.5%, 28.6%, and 41.2% in laryngeal, oropharyngeal, and hypopharyngeal cancers, respectively. Radiotherapy was de ned as an independent risk factor in hypopharyngeal cancer patients with secondary cancers. No direct correlation was found between secondary carcinogenesis and alcohol consumption, smoking, or aging. ConclusionsPatients with hypopharyngeal cancer require close follow-up as they are at high risk of developing secondary cancer, possibly because out-of-eld radiation exposure may induce systemic secondary carcinogenesis in hypopharyngeal cancer patients with genetic abnormality induced by alcohol consumption.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk factors of secondary cancer in laryngeal, oropharyngeal, or hypopharyngeal cancer after definitive therapy

Nishimura,

Takahashi,

Sano

et al. 2023

Int J Clin Oncol

Self Cite

View full text Add to dashboard Cite

show abstract

Risk factors of secondary cancer in laryngeal, oropharyngeal, or hypopharyngeal cancer after definitive therapy

Nishimura

Takahashi

Sano

et al. 2023

Preprint

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Background Our previous research showed that a high rate of secondary carcinogenesis is observed during follow-up after transoral surgery in patients with early-stage laryngeal, oropharyngeal, and hypopharyngeal cancers. We speculate that the contributing factors are alcohol drinking, smoking, and aging; however, we could not provide clear evidence. In this study, we aimed to identify the risk factors for secondary carcinogenesis in patients with these cancers, particularly factors associated with drinking and/or smoking. Methods The medical records of all-stage laryngeal, oropharyngeal, and hypopharyngeal cancer patients who had undergone definitive treatment were retrospectively analyzed. Assessments included visual and endoscopic observations of the primary site, enhanced cervical CT or US of the primary site and regional lymph nodes, PET-CT, and enhanced whole-body CT. Clinical characteristics were compared in patients with and without secondary carcinogenesis and in patients with hypopharyngeal cancer and patients with other cancers. Results Hypopharyngeal cancer was an independent risk factor for secondary cancer. The 5-year incidence rate of secondary cancer was 25.5%, 28.6%, and 41.2% in laryngeal, oropharyngeal, and hypopharyngeal cancers, respectively. Radiotherapy was defined as an independent risk factor in hypopharyngeal cancer patients with secondary cancers. No direct correlation was found between secondary carcinogenesis and alcohol consumption, smoking, or aging. Conclusions Patients with hypopharyngeal cancer require close follow-up as they are at high risk of developing secondary cancer, possibly because out-of-field radiation exposure may induce systemic secondary carcinogenesis in hypopharyngeal cancer patients with genetic abnormality induced by alcohol consumption.

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A risk factor for newly diagnosed secondary cancer in patients with early-stage laryngeal, oropharyngeal, or hypopharyngeal cancer: sub-analysis of a prospective observation study

Cited by 2 publications

References 22 publications

Risk factors of secondary cancer in laryngeal, oropharyngeal, or hypopharyngeal cancer after definitive therapy

Risk factors of secondary cancer in laryngeal, oropharyngeal, or hypopharyngeal cancer after definitive therapy

Risk factors of secondary cancer in laryngeal, oropharyngeal, or hypopharyngeal cancer after definitive therapy

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