Through the research and development of the regression prediction function of support vector machine, this paper applies it to the prediction of drilling fluid performance parameters and the formulation design of drilling fluid. The research in this paper can reduce the experimental workload and improve the efficiency of drilling fluid formulation design. The apparent viscosity (AV), plastic viscosity (PV), API filter loss (FLAPI), and roll recovery (R) of the drilling fluid were selected as the inspection objects of the drilling fluid performance parameters, and the support vector machine was used to establish a model for predicting the drilling fluid performance parameters. This predictive model was used as part of the overall drilling fluid formulation optimization design model. For a given drilling fluid performance parameter requirement, this model can be applied to reverse the addition of various treatment agents, and finally, the prediction accuracy of the model is verified by experiments.