A Risk Scale for Predicting Extensive Subclinical Spread of Nonmelanoma Skin Cancer

Abstract

background. The clinical appearance of nonmelanoma skin cancer may represent only a portion of microscopic tumor invasion. objective. To develop a scale based on high-risk characteristics for predicting the probability of extensive subclinical spread of nonmelanoma skin cancer. methods. Retrospective analysis of 1095 Mohs micrographic surgical cases (MMS) yielded high-risk factors for extensive tumor spread, defined as requirement of Ն 3 MMS layers. Predictive characteristics included: any BCC on the nose, morpheaform BCC on the cheek, neck tumors and recurrent BCC

Mohs micrographic surgery for basal cell carcinomas: appropriateness of ‘Rotterdam’ criteria and predictive factors for three or more stages

“…12 Identifying predictors for the degree of subclinical tumour spread can guide surgeons in efficient scheduling of patients and in estimating time needed for operation and reconstruction. 12,14,17 Patient and BCC characteristics A retrospective study was done based on digital patient records to collect pre-operative patient and tumour characteristics. The following variables were recorded for all patients: date of birth, age at time of MMS, gender, tumour size, anatomical location, histological BCC subtype, primary or recurrent BCC and number of required stages for microscopic tumour clearance.…”

Prospective follow-up after curettage-cryosurgery for scalp and face skin cancers

“…NMSCs of these regions have been considered to carry a higher risk of recurrence than skin cancers in other regions of the body such as the trunk and extremities. 17,18 There are only a few published comparative studies with long-term follow-up 19,20 and they are burdened with a high variability in recurrence rates. 21 The objectives of this study were to assess prospectively, in a northern European setting (the West coast of Sweden), the patient tolerance, the rate of complications, the cosmetic result, and the long-term recurrence rate after treatment of NMSCs of the scalp and face with standardized curettage and CS (CCS).…”

Recurrent Squamous Cell Carcinoma Presenting as Facial Nerve Palsy in the Setting of Organ Transplantation

“…Unrecognized perineural spread, however, can result in delayed treatment of the cancer, tissue destruction, and even death. 1,5 Skin cancers that spread to the perineural space many times express ''skip'' lesions throughout the nerve suggesting noncontiguous spread of the cancer along the nerves. Therefore, recurrence of these cancers is still likely after a resection with negative margins.…”

“…O ne million new cases of nonmelanoma skin cancer are diagnosed annually in the United States with squamous cell carcinomas (SCC) comprising 20%. [1][2][3] The majority of skin cancers in transplant patients are SCC. 4 Tumors occurring in the head and neck region have the propensity to spread into the perineural space.…”