A risk scoring system for predicting Streptococcus suis hearing loss: A 13-year retrospective cohort study

Rayanakorn, Ajaree; Katip, Wasan; Goh, Bey Hing; Oberdorfer, Peninnah; Lee, Learn‐Han

doi:10.1371/journal.pone.0228488

Cited by 15 publications

(14 citation statements)

References 17 publications

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“…The prevalence of S. suis infections in humans has shown a notable increase in the last decade, with highest prevalence values in countries with a high pig density (i.e., Southeast Asia) [ 74 ]. There is a wide clinical variation in the presentation of S. suis infections in humans, but meningitis and sepsis are the most common and serious clinical manifestations of S. suis infections; these pathologies are usually accompanied with hearing loss in the surviving patients (which was also demonstrated in our Case 2) [ 75 , 76 , 77 ]. According to animal experiments, the human pathomechanism of hearing loss is likely from the invasion of S. suis to the perilymph, via the cochlear aqueduct, resulting in suppurative labyrinthitis [ 78 ].…”

Section: Discussionmentioning

confidence: 77%

Streptococcus suis: An Underestimated Emerging Pathogen in Hungary?

et al. 2020

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Streptococcus suis (S. suis) is an emerging zoonotic pathogen, demonstrated as an etiological agent in human infections in increasing frequency, including diseases like purulent meningitis, sepsis, uveitis-endophtalmitis and arthritis. Due to the increased availability and utility of novel diagnostic technologies in clinical microbiology, more studies have been published on the epidemiology of S. suis, both in veterinary and human medicine; however, there are no comprehensive data available regarding human S. suis infections from East-Central European countries. As a part of our study, data were collected from the National Bacteriological Surveillance (NBS) system on patients who had at least one positive microbiological result for S. suis, corresponding to an 18-year study period (2002–2019). n = 74 S. suis strains were isolated from invasive human infections, corresponding to 34 patients. The number of affected patients was 1.89 ± 1.53/year (range: 0–5). Most isolates originated from blood culture (63.5%) and cerebrospinal fluid (18.9%) samples. Additionally, we present detailed documentation of three instructive cases from three regions of the country and with three distinctly different outcomes. Hungary has traditional agriculture, the significant portion of which includes the production and consumption of pork meat, with characteristic preparation and consumption customs and unfavorable epidemiological characteristics (alcohol consumption, prevalence of malignant diseases or diabetes), which have all been described as important predisposing factors for the development of serious infections. Clinicians and microbiologist need to be vigilant even in nonendemic areas, especially if the patients have a history of occupational hazards or having close contact with infected pigs.

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Section: Discussionmentioning

confidence: 77%

Streptococcus suis: An Underestimated Emerging Pathogen in Hungary?

et al. 2020

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“…Raw pork eating practice was also identified as one of significant predictors (raw pork eating, meningitis, and vestibular dysfunction) of S . suis hearing loss which is a major sequelae among most surviving patients [ 41 ]. Considering significant economic burden incurred from S .…”

Section: Discussionmentioning

confidence: 99%

Burden of disease and productivity impact of Streptococcus suis infection in Thailand

et al. 2021

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Background Streptoccocus suis (S.suis) infection is a neglected zoonosis disease in humans mainly affects men of working age. We estimated the health and economic burden of S.suis infection in Thailand in terms of years of life lost, quality-adjusted life years (QALYs) lost, and productivity-adjusted life years (PALYs) lost which is a novel measure that adjusts years of life lived for productivity loss attributable to disease. Methods A decision-analytic Markov model was developed to simulate the impact of S. suis infection and its major complications: death, meningitis and infective endocarditis among Thai people in 2019 with starting age of 51 years. Transition probabilities, and inputs pertaining to costs, utilities and productivity impairment associated with long-term complications were derived from published sources. A lifetime time horizon with follow-up until death or age 100 years was adopted. The simulation was repeated assuming that the cohort had not been infected with S.suis. The differences between the two set of model outputs in years of life, QALYs, and PALYs lived reflected the impact of S.suis infection. An annual discount rate of 3% was applied to both costs and outcomes. One-way sensitivity analyses and Monte Carlo simulation modeling technique using 10,000 iterations were performed to assess the impact of uncertainty in the model. Key results This cohort incurred 769 (95% uncertainty interval [UI]: 695 to 841) years of life lost (14% of predicted years of life lived if infection had not occurred), 826 (95% UI: 588 to 1,098) QALYs lost (21%) and 793 (95%UI: 717 to 867) PALYs (15%) lost. These equated to an average of 2.46 years of life, 2.64 QALYs and 2.54 PALYs lost per person. The loss in PALYs was associated with a loss of 346 (95% UI: 240 to 461) million Thai baht (US$11.3 million) in GDP, which equated to 1.1 million Thai baht (US$ 36,033) lost per person. Conclusions S.suis infection imposes a significant economic burden both in terms of health and productivity. Further research to investigate the effectiveness of public health awareness programs and disease control interventions should be mandated to provide a clearer picture for decision making in public health strategies and resource allocations.

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“…It is believed that S. suis can directly affect the auditory nerve or cause hemorrhagic labyrinthitis [ 9 , 10 ]. A risk scoring system for predicting S. suis hearing loss is under development [ 11 ]. Despite considerable prevalence, little is known regarding the etiopathogenesis of hearing impairment observed in the later stages of S. suis meningitis.…”

Section: Discussionmentioning

confidence: 99%

Meningitis due to Streptococcus suis in Two Patients with Occupational Exposure from Northeastern Brazil

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et al. 2021

Case Reports in Infectious Diseases

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Streptococcus suis is an emerging zoonotic agent that causes bacterial meningitis. S. suis is an encapsulated Gram-positive, facultative anaerobic bacterium. This infection usually manifests in humans as meningitis, endocarditis, septicemia, and/or arthritis. The primary groups at risk for S. suis infection are individuals occupationally exposed to pigs and/or pork, for example, farmers, butchers, and hunters. Herein, we report two cases of meningitis related to S. suis with occupational exposure from the Ceará state, northeastern Brazil.

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A risk scoring system for predicting Streptococcus suis hearing loss: A 13-year retrospective cohort study

Cited by 15 publications

References 17 publications

Streptococcus suis: An Underestimated Emerging Pathogen in Hungary?

Streptococcus suis: An Underestimated Emerging Pathogen in Hungary?

Burden of disease and productivity impact of Streptococcus suis infection in Thailand

Meningitis due to Streptococcus suis in Two Patients with Occupational Exposure from Northeastern Brazil

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