“…In all these studies the notion of uncertainty is partly conflated with that of risk of project failure, or inversely, probability of success (PoS). However, several studies introduce measures of uncertainty that capture variance of R&D portfolio performance more broadly, such as: Value at Risk (VaR) or Conditional Value at Risk (CVaR) [34], fuzzy value [43], reward/loss ratios [38,44,46] or value probability thresholds [34,38,40,[44][45][46]48,49], variance of portfolio value distribution [39,42,44,50,51], semivariance below or above portfolio value thresholds [42], or covariance of portfolio value, cumulative probability distribution of portfolio value and Gini criteria [41]. A final set of methods emerging from the health economic literature attempt to measure the impact of this variance on the probability that a portfolio is chosen [42,52,53].…”