A Robust Design for Cellular Vehicles of Gold Nanorods for Multimodal Imaging

Abstract

Ref. [82] was not included in the originally published version of this article. It should be added to the second paragraph on page 7179, which then reads as follows: "More recently, the notion to exploit the natural tropism of cells, such as tumor-associated macrophages, [35][36][37][38][39] T cells, [40,82] mesenchymal stem cells, [41][42][43] and neural stem cells, [44,45] has begun to emerge as a radical alternative."Ref.

1064‐nm‐resonant gold nanorods for photoacoustic theranostics within permissible exposure limits

“…The upper panel of Figure displays representative micrographs of cells treated for 24 hours with 50 ppm Au GNRs@CPP. As already reported elsewhere , the accumulation of GNRs did not modify the cellular morphology but for the occasional extrusion of pseudopodia and the occurrence of a dark particulate inside the perinuclear cytoplasm, probably consisting of endosomal vesicles enclosing a high density of gold. The lower panel of Figure displays the viability of cells treated with GNRs@CPP at different concentrations and incubation times.…”

“…Also, the effect of accumulation from pulse to pulse is rather negligible, and the average power supplied to the pellets is a small fraction of that required for photothermal treatments. An exposure to 100 mJ/cm 2 for a repetition rate of 5 Hz amounts to 500 mW/cm 2 , which is only about 1% of the typical power in use in photothermal tests . In addition, the typical duration of a hyperthermia treatment is in the order of several tens of minutes, as opposed to an overall timespan of 20 seconds, in this work.…”

A Gold Nanocage/Cluster Hybrid Structure for Whole‐Body Multispectral Optoacoustic Tomography Imaging, EGFR Inhibitor Delivery, and Photothermal Therapy

“…Preparation of AuNCs : AuNCs were prepared using a galvanic replacement between silver nanocubes and chloroauric acid (HAuCl 4 ) following previously reported procedures . Briefly, for the synthesis of Ag nanocubes, 10 mL of ethylene glycol was heated to 150 °C under magnetic stirring in oil bath, and 0.12 mL of 3 × 10 −3 m NaSH solution (in EG) was quickly added into the heated solution.…”

“…Compared with pure optical imaging (e.g., fluorescent imaging), the optoacoustic (OA) imaging technique is an attractive imaging modality that functions by detecting the ultrasound waves generated by the thermoelastic expansion of tissue resulting from the laser pulse absorption . This technology is not affected by photon scattering and thus can provide high‐resolution optical images deep inside biological tissues . Particularly, the multispectral optoacoustic tomography (MSOT), which is a spectral optoacoustic technique achieved by irradiating an object with multiple wavelengths and allowing the system to detect ultrasound waves from different photoabsorbing substances in the tissue, has shown its great potential in a wide range of biological imaging.…”

A Nanoprobe for Diagnosing and Mapping Lymphatic Metastasis of Tumor Using 3D Multispectral Optoacoustic Tomography Owing to Aggregation/Deaggregation Induced Spectral Change

“…Nevertheless, based on diffuse‐light‐based imaging, pure optical detection techniques have some limitations such as relatively low spatial resolution and penetration depth because of strong light scattering in deep tissue . On the other hand, optoacoustic (OA) imaging, also known as photoacoustic (PA) imaging, integrates the good contrast and high sensitivity attainable in optical imaging with the deep penetration and high resolution of ultrasound . With pulsed‐laser light illumination, the OA contrast agents (either endogenous or exogenous) undergo thermoelastic expansion, and produce ultrasound waves which are detected with an ultrasound detector.…”