2023
DOI: 10.21203/rs.3.rs-3229244/v1
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A robust penalized-regression-based method for multivariable Mendelian randomization using GWAS summary statistics

Hongyu Zhao,
Wei Jiang,
Shuang Song
et al.

Abstract: Mendelian randomization (MR) is a statistical approach to inferring the causal relationships from genome-wide association studies (GWAS) by using genetic variants as instrumental variables (IVs). As IVs, the selected genetic variants should be solely associated with the exposure of interest, and have no associations with confounders and the studied outcome except through the exposure. Sometimes the selected genetic variants have effects on the outcome through other pathways, a phenomenon known as horizontal pl… Show more

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