A rogue cells an indicator of cancer risk due to the action of bacterial restriction endonucleases?

Ahuja, Y.R.; Obe, Günter

doi:10.1016/0027-5107(94)90013-2

Cited by 14 publications

(2 citation statements)

References 27 publications

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“…Their presence is transient, and several hyp otheses h ave been form ulated concerning th eir cause. These include viral infection in which retrotransposons induce ch rom osom al rearran gem en ts, the release of endon ucleases after a bacterial infection, a defective D N A synthesis or repair system resulting from a m utation, and exp osure to an ingested alphaem itting particle (N eel et al 1992, Ah uja andO be 1994), but none of these explan ations is really satisfactory. Rogue cells perh aps result from a com bination of rare events of a different and undeterm ined natu re (Bochkov and Katosova 1994) an d we wonder whether groun d irradiation with particles of solar or cosm ic origin m ight be one of them .…”

Section: Discussionmentioning

confidence: 96%

Radiation-induced chromosome damage in astronauts' lymphocytes

Testard

Ricoul

Hoffschir³

et al. 1996

International Journal of Radiation Biology

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The increased number of manned space missions has made it important to estimate the biological risks encountered by astronauts. As they are exposed to cosmic rays, especially ions with high linear energy transfer (LET), it is necessary to estimate the doses they receive. The most sensitive biological dosimetry used is based on the quantification of radiation-induced chromosome damage to human lymphocytes. After the space missions ANTARES (1992) and ALTAIR (1993), we performed cytogenetic analysis of blood samples from seven astronauts who had spent from 2 weeks to 6 months in space. After 2 or 3 weeks, the X-ray equivalent dose was found to be below the cytogenetic detection level of 20 mGy. After 6 months, the biological dose greatly varied among the astronauts, from 95 to 455 mGy equivalent dose. These doses are in the same range as those estimated by physical dosimetry (90 mGy absorbed dose and 180 mSv equivalent dose). Some blood cells exhibited the same cytogenetic pattern as the 'rogue cells' occasionally observed in controls, but with a higher frequency. We suggest that rogue cells might result from irradiation with high-LET particles of cosmic origin. However, the responsibility of such cells for the long-term effects of cosmic irradiation remains unknown and must be investigated.

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Section: Discussionmentioning

confidence: 96%

Radiation-induced chromosome damage in astronauts' lymphocytes

Testard

Ricoul

Hoffschir³

et al. 1996

International Journal of Radiation Biology

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“…Moreover, there is no consensus on the causes of their appearance. Several hypotheses were proposed to explain the scanty data on the presence of these cells in persons exposed to various mutagenic environmental factors: biological (viruses and bacteria) [6,7], physical [5,8], and chemical [8]. Today the main task on the agenda is understanding the causes of MAC induction and the biological significance of these cells.…”

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confidence: 99%

Mutliaberrant cell formation caused by exposure to internal densely-ionizing irradiation

2004

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The origin of multiaberrant cells (MACs) was studied by comparing the structure and intensity of chromosome damage in peripheral blood lymphocytes of two groups of people: workers of Siberian Chemical Plant differing in the content of plutonium-239 in their bodies, and inhabitants of a non-polluted settlement (control group). Plutonium-239 is known to be a long-lived densely-ionizing source of α -radiation with high linear energy delivery; therefore, it has a stronger effect on cell hereditary structures than γ -rays. In persons with the content of plutonium-239 higher than 13 nCu, the frequency of MAC was 0.105% which at least tenfold exceeds the spontaneous level. The chromosome-type aberrations that are usually induced by ionizing radiation predominated in MACs. Our results suggest that MAC formation may be caused by internal body irradiation with the incorporated sources of densely-ionizing radiation.

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