A role for 4-hydroxy-2-nonenal in premature placental senescence in preeclampsia and intrauterine growth restriction

Tasta, Oriane; Swiader, Audrey; Grazide, Marie-Hélène; Rouahi, Myriam; Parant, Olivier; Vayssière, Christophe; Bujold, Emmanuel; Salvayre, Robert; Guerby, Paul; Nègre‐Salvayre, Anne

doi:10.1016/j.freeradbiomed.2021.01.002

Cited by 18 publications

(14 citation statements)

References 66 publications

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“…Unfortunately, severe preeclampsia /eclampsia led to many complications for the mother and her baby (Tasta et al,2021). Globally, stillbirths due to severe preeclampsia /eclampsia of the estimated 2.6 million stillbirths annually, it has been estimated that the HDPs precede 10% of early neonatal deaths (8/1000 live births) (Rozario, 2019).…”

Section: Complications Of Severe Preeclampsia /Eclampsiamentioning

confidence: 99%

Mothers’ Experiences of Severe Preeclampsia/ Eclampsia: A Narrative Literature Review

2023

JPTCP

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Severe preeclampsia /eclampsia is a particularly serious issue and is highly associated with higher rates of adverse maternal and neonatal outcomes. This review aims to emphasize the importance of investigating and studying the mothers' experiences of severe preeclampsia/eclampsia. This literature review includes recent and up-to-date qualitative and quantitative studies, recruited from different databases: The Jordanian database for nursing research, Medline (Medical literature online), CINAHL (Cumulative Index to Nursing and Allied Health Literature) PubMed, Research Gates, Science Direct. Also, a Google Scholar search was used to select further studies. The reviewed literature showed these physical complications associated with psychological complications make the experiences unpleasant and complex. Healthcare providers should be aware of these adverse effects, to change the way of managing and care affected mothers. Mother experiences of severe preeclampsia/ eclampsia seem very hurtful and complex shaped by many factors, further and deeper investigation of the mother's experience for it is very important for the mother's and baby's health.

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Section: Complications Of Severe Preeclampsia /Eclampsiamentioning

confidence: 99%

Mothers’ Experiences of Severe Preeclampsia/ Eclampsia: A Narrative Literature Review

2023

JPTCP

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“…Excessive cell senescence at advanced maternal age may be responsible for the high probability of adverse pregnancy outcomes. loss, and Trisomy 21 [82][83][84][85]. In these complicated pregnancies, the exaggeration of cell senescence rather than normal placental aging may be inevitable.…”

Section: Adverse Pregnancy Outcomes and Excessive Cell Senescence At ...mentioning

confidence: 99%

Flip a coin: cell senescence at the maternal–fetal interface

Gong

Muyayalo

Zhang

et al. 2023

Biology of Reproduction

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During pregnancy, cell senescence at the maternal-fetal interface is required for maternal well-being, placental development, and fetal growth. However, recent reports have shown that aberrant cell senescence is associated with multiple pregnancy-associated abnormalities, such as preeclampsia, fetal growth restrictions, recurrent pregnancy loss, and preterm birth. Therefore, the role and impact of cell senescence during pregnancy requires further comprehension. In this review, we discuss the principal role of cell senescence at the maternal-fetal interface, emphasizing its “bright side” during decidualization, placentation, and parturition. Additionally, we highlight the impact of its deregulation and how this “dark side” promotes pregnancy-associated abnormalities. Furthermore, we discuss novel and less invasive therapeutic practices associated with the modulation of cell senescence during pregnancy.

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“…Premature placental senescence is a critical characteristic of pre-eclampsia, with senescenceassociated secretory phenotype and increased expression of p53 and p21, which are markers of cellular senescence. SIRT1 is also a specific marker of senescence, and SIRT1 deficiency leads to premature senescence of placentas during placentation [50][51][52][53]. Interestingly, Xiong et al found that SIRT1 deficiency promotes the acetylation of P53, elevates the expression level of P21, and impairs trophoblast invasion and migration in advanced maternal age (AMA) pregnancy women, indicating that SIRT1 might involve in the pathogenesis of pre-eclampsia by inducing placental senescence [50].…”

Section: Sirt1 Affects Placental Senescencementioning

confidence: 99%

SIRT1: A Novel Protective Molecule in Pre-eclampsia

Liu¹,

Wang²,

Pei³

et al. 2022

Int. J. Med. Sci.

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Pre-eclampsia is a severe pregnant complication, mainly characterized by insufficient trophoblast invasion, impaired uterine spiral artery remodeling, placental hypoxia and ischemia, and endothelial dysfunction. However, the potential mechanisms of pre-eclampsia remain unclear. SIRT1 is a NAD+-dependent deacetylase, involving in multiple biological processes, including energy metabolism, oxidative stress, inflammatory response, and cellular autophagy. Several studies showed that SIRT1 might play a vital role in the pathogenesis of pre-eclampsia. In this review, we aim to integrate the latest research on SIRT1 and pre-eclampsia to explore the comprehensive mechanisms of SIRT1 in pre-eclampsia. More specifically, SIRT1 might affect placental development and trophoblast invasion through autophagy and senescence in pre-eclampsia, and SIRT1 protects vascular endothelial cells from oxidative stress, inflammatory response, autophagy, and senescence. Furthermore, SIRT1 deficiency mice showed typical pre-eclampsia-like performances, which can be reversed via direct SIRT1 supplement or SIRT1 agonist treatment. Additionally, resveratrol, a SIRT1 agonist, attenuates vascular endothelial injury and placental dysfunction, and exerts protective effect on decreasing blood pressure. In this review, we provide new insights into the development of pre-eclampsia, which can establish a theoretical basis for prevention and treatment for pre-eclampsia. Besides, we also propose questions that still need to be further addressed in order to elucidate the comprehensive molecular mechanisms of pre-eclampsia in the future.

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A role for 4-hydroxy-2-nonenal in premature placental senescence in preeclampsia and intrauterine growth restriction

Cited by 18 publications

References 66 publications

Mothers’ Experiences of Severe Preeclampsia/ Eclampsia: A Narrative Literature Review

Mothers’ Experiences of Severe Preeclampsia/ Eclampsia: A Narrative Literature Review

Flip a coin: cell senescence at the maternal–fetal interface

SIRT1: A Novel Protective Molecule in Pre-eclampsia

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