A role for amines in the antidepressant effect of exercise

Ransford, Charles

doi:10.1249/00005768-198201000-00001

Cited by 204 publications

(95 citation statements)

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“…Our findings, obtained through study of relatively healthy and happy students, are consistent with reviews on the effects of physical activity on mental health and the monoamine theory of the feel-good influence of physical activity (Acevedo & Ekkekakis, 2006; Chaouloff, 1989; Ransford, 1982; Rethorst et al, 2009; Wipfli et al, 2008) and research showing that self-initiated physical activity leads to immediate increases in pleasant-activated feelings in normal and depressed populations (Mata et al, 2011). That daily free-time physical activity was associated with pleasant-activated feeling states, but not with pleasant-deactivated feeling states suggests some differentiation with respect to activated versus deactivated feeling states.…”

Section: Discussionsupporting

confidence: 89%

“…The monoamine enhancement theory proposes physical activity enhances synaptic transmission of monoamines in the brain, including norepinephrine, dopamine, and serotonin (Acevedo & Ekkekakis, 2006; Chaouloff, 1989; Ransford, 1982). These monoamines result in feelings of elevated mood and activation – a pattern bearing strong similarity to pleasant-activated feelings.…”

Section: The Feel-good Effects Of Physical Activitymentioning

confidence: 99%

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Unpacking the Feel-Good Effect of Free-Time Physical Activity: Between- and Within-Person Associations With Pleasant–Activated Feeling States

Hyde

Conroy

Pincus

et al. 2011

Journal of Sport and Exercise Psychology

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Physical activity is a widely accessible and effective tool for improving well-being. This study aimed to unpack the feel good effects of free-time physical activity. Multilevel models were applied to repeated measures of daily free-time physical activity and four types of feeling states obtained from 190 undergraduate students. Physical activity was not associated with pleasant-deactivated, unpleasant-activated, or unpleasant-deactivated feelings. People who were more physically active overall had higher pleasant-activated feelings than people who were less physically active, and on days when people were more physically active than was typical for them, they reported higher levels of pleasant-activated feelings. Both the between- and within-person associations remained significant after controlling for day-of-week, sleep quality, and carryover effects of previous day free-time physical activity and feeling states. Results suggest that both increases in overall levels and acute bouts of free-time physical activity are associated with increases in feelings of pleasant-activation.

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Section: Discussionsupporting

confidence: 89%

Section: The Feel-good Effects Of Physical Activitymentioning

confidence: 99%

Unpacking the Feel-Good Effect of Free-Time Physical Activity: Between- and Within-Person Associations With Pleasant–Activated Feeling States

Hyde

Conroy

Pincus

et al. 2011

Journal of Sport and Exercise Psychology

View full text Add to dashboard Cite

show abstract

“…The self-efficacy/mastery hypothesis [36] suggests that physical activity could be seen as a challenging activity, the ability of individuals to be physically active on a regular basis may lead to improvements in their mood and self-confidence. Finally, the social interaction hypothesis [37] views social relationships resulting from physical activity practice and associated social support among individuals involved in physical activity to play a role in the effects of physical activity on mental health.…”

Section: Discussionmentioning

confidence: 99%

“…The monoamines hypothesis [37, 38] based on animal models suggests that physical activity increases the synaptic transmission of monoamines, which are assumed to have antidepressant effects. Another hypothesis [37] highlights the role of endorphins, released upon physical activity, on the central nervous system to create feeling of calm and improved mood after physical activity [39]. …”

Section: Discussionmentioning

confidence: 99%

Bidirectional association between physical activity and symptoms of anxiety and depression: the Whitehall II study

et al. 2012

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Although it has been hypothesized that the association of physical activity with depressive and anxiety symptoms is bidirectional, few studies have examined this issue in a prospective setting. We studied this bidirectional association using data on physical activity and symptoms of anxiety and depression at three points in time over 8 years. A total of 9,309 participants of the British Whitehall II prospective cohort study provided data on physical activity, anxiety and depression symptoms and 10 covariates at baseline in 1985. We analysed the associations of physical activity with anxiety and/or depression symptoms using multinomial logistic regression (with anxiety and depression symptoms as dependent variables) and binary logistic regression (with physical activity as the dependent variable). There was a cross-sectional inverse association between physical activity and anxiety and/or depressive symptoms at baseline (ORs between 0.63 and 0.72). In cumulative analyses, regular physical activity across all three data waves, but not irregular physical activity, was associated with reduced likelihood of depressive symptoms at follow-up (OR = 0.71, 95 % CI 0.54, 0.99). In a converse analysis, participants with anxiety and depression symptoms at baseline had higher odds of not meeting the recommended levels of physical activity at follow-up (OR = 1.79, 95 % CI 1.17, 2.74). This was also the case in individuals with anxiety and/or depression symptoms at both baseline and follow-up (OR = 1.70, 95 % CI 1.10, 2.63). The association between physical activity and symptoms of anxiety and/or depression appears to be bidirectional.

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“…Another study discovered that exercise reduces the amount of urine cortisol and reduces the depressive state in adolescent females ( 57 ). One reason exercise may aid in mitigating symptoms of depression is that it promotes serotonin and dopamine secretion ( 67 ). Another possibility is that exercise may increase endogenous opioid activity in the central and peripheral nervous system, which could help fi ght depression (and stress) ( 72 ).…”

Section: Discussionmentioning

confidence: 99%

Hypercortisolism as a Potential Concern for Submariners

Reini¹

2010

aviat space environ med

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Cortisol is a stress-response hormone that is important for survivability in fight or flight situations. Hypercortisolism is a state of chronically elevated cortisol levels due to a failure to return to, or maintain baseline levels. It is a condition that is often undiagnosed and can aid in the development of many physiological and psychological health problems. Some of the health ailments associated with hypercortisolism include metabolic syndrome, decreases in bone mineral density, and depression. Chronic stress and sleep deprivation are two common causes of hypercortisolism, both areas of concern within the submarine community. This review discusses the etiology of hypercortisolism and the likelihood of submariner vulnerability to the condition along with health problems associated with it. Lastly, strategies to prevent chronic elevation of cortisol and mitigate the potential health risks associated with the condition are covered.

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A role for amines in the antidepressant effect of exercise

Cited by 204 publications

References 0 publications

Unpacking the Feel-Good Effect of Free-Time Physical Activity: Between- and Within-Person Associations With Pleasant–Activated Feeling States

Unpacking the Feel-Good Effect of Free-Time Physical Activity: Between- and Within-Person Associations With Pleasant–Activated Feeling States

Bidirectional association between physical activity and symptoms of anxiety and depression: the Whitehall II study

Hypercortisolism as a Potential Concern for Submariners

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