A role for AP-1 in apoptosis: the case for and against

Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL

“…The best-known AP-1 complex contains c-Jun and c-Fos, although other Jun proteins (JunB and JunD) and Fos proteins (Fra-1, Fra-2 and FosB) have been reported (14). Numerous reports indicate that AP-1 induces apoptosis by transactivating proapoptotic genes (15)(16)(17). For example, induction of c-Jun and c-Fos was reported in lymphoid cells after growth factor deprivation and this induction was associated with apoptosis (18).…”

c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation

“…In It is also possible that the reduced cellular growth in c-Junexpressing prostate cancer cells is owing to increased apoptosis, since c-Jun transactivation is known to induce apoptosis in neurons, lymphocytes, and hepatocytes (reviewed in Ameyar et al, 2003). Future work will determine if overexpression of c-Jun in LNCaP cells leads to decreased cell-cycle progression and/or increased apoptosis.…”

AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene

“…We show that this regulation is influenced by the heterodimer composition, and that c-JunBFra-1 AP-1 dimers cooperate with Ras to regulate the ARF promoters. Early studies on AP-1 function focused mainly on its role in cell proliferation and transformation (Angel and Karin, 1991;Ameyar et al, 2003). The last few years, however, have seen a shift in our understanding of the role of AP-1 in cell-fate decisions.…”