A role for CA3 in social recognition memory

Chiang, Ming Ching; Huang, Arthur; Wintzer, Marie E.; Ohshima, Toshio; McHugh, Thomas J.

doi:10.1016/j.bbr.2018.01.019

Cited by 104 publications

(94 citation statements)

References 60 publications

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“…Optogenetic inhibition of entorhinal inputs in the dorsal DG does not impact sociability but impairs social recognition in mice, implicating the EC‐DG synapse as an important component for social memory. However, another recent study shows that the deletion of the n ‐methyl‐ d ‐aspartate receptor (NMDAR) NR1 subunit from the DG granule cells—effectively eliminating NMDAR‐dependent plasticity—does not produce deficits in social memory of male mice . Thus, the DG's role in social memory remains unclear.…”

Section: Oxytocin and Vasopressin Modulation Of Hippocampal‐dependentmentioning

confidence: 99%

“…Unlike the DG, selective removal of the NMDAR NR1 subunit from the CA3 region impairs social recognition memory. Furthermore, chemogenetic silencing shows that the ventral CA3 is necessary for the encoding but not recall of social recognition memory whereas the dorsal CA3 is dispensable for both …”

Section: Oxytocin and Vasopressin Modulation Of Hippocampal‐dependentmentioning

confidence: 99%

“…Fibers from CA2 are predominant in the stratum oriens and form synapses onto the deep layer of CA1 pyramidal neurons whereas CA3 axons are largely found in the stratum radiatum . Impairments of social memory are seen with selective removal of the NMDAR NR1 subunit in the CA1 region . Individual cells within the ventral CA1 are implicated in the storage of conspecific‐related social memories.…”

Section: Oxytocin and Vasopressin Modulation Of Hippocampal‐dependentmentioning

confidence: 99%

“…However, another recent study shows that the deletion of the N-methyl-D-aspartate receptor (NMDAR) NR1 subunit from the DG granule cells-effectively eliminating NMDARdependent plasticity-does not produce deficits in social memory of male mice. 93 Thus, the DG's role in social memory remains unclear.…”

Section: The Hippocampus and Social Memorymentioning

confidence: 99%

“…Furthermore, chemogenetic silencing shows that the ventral CA3 is necessary for the encoding but not recall of social recognition memory whereas the dorsal CA3 is dispensable for both. 93 The dorsal CA2 region receives excitatory inputs from the DG, CA3 and entorhinal cortex 44,96,97 and is implicated in both social memory and aggression. 49,[98][99][100][101] Outputs from the DG to CA2 exhibit a longitudinal spread along the septotemporal axis where the intermediate and dorsal regions of the DG can effectively innervate the entire septotemporal span of the CA2.…”

Section: The Hippocampus and Social Memorymentioning

confidence: 99%

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Oxytocin and vasopressin in the rodent hippocampus

Cilz

Cymerblit‐Sabba

Young

2018

Genes Brain and Behavior

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The role of the hippocampus in social memory and behavior is under intense investigation. Oxytocin (Oxt) and vasopressin (Avp) are two neuropeptides with many central actions related to social cognition. Oxt‐ and Avp‐expressing fibers are abundant in the hippocampus and receptors for both peptides are seen throughout the different subfields, suggesting that Oxt and Avp modulate hippocampal‐dependent processes. In this review, we first focus on the anatomical sources of Oxt and Avp input to the hippocampus and consider the distribution of their corresponding receptors in different hippocampal subfields and neuronal populations. We next discuss the behavioral outcomes related to social memory seen with perturbation of hippocampal Oxt and Avp signaling. Finally, we review Oxt and Avp modulatory mechanisms in the hippocampus that may underlie the behavioral roles for both peptides.

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Section: Oxytocin and Vasopressin Modulation Of Hippocampal‐dependentmentioning

confidence: 99%

Section: Oxytocin and Vasopressin Modulation Of Hippocampal‐dependentmentioning

confidence: 99%

Section: Oxytocin and Vasopressin Modulation Of Hippocampal‐dependentmentioning

confidence: 99%

Section: The Hippocampus and Social Memorymentioning

confidence: 99%

Section: The Hippocampus and Social Memorymentioning

confidence: 99%

See 3 more Smart Citations

Oxytocin and vasopressin in the rodent hippocampus

Cilz

Cymerblit‐Sabba

Young

2018

Genes Brain and Behavior

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Circuits underlying social function and dysfunction

Wang,

Yueh,

Chau

et al. 2023

Autism Research

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Substantial advances have been made toward understanding the genetic and environmental risk factors for autism, a neurodevelopmental disorder with social impairment as a core feature. In combination with optogenetic and chemogenetic tools to manipulate neural circuits in vivo, it is now possible to use model systems to test how specific neural circuits underlie social function and dysfunction. Here, we review the literature that has identified circuits associated with social interest (sociability), social reward, social memory, dominance, and aggression, and we outline a preliminary roadmap of the neural circuits driving these social behaviors. We highlight the neural circuitry underlying each behavioral domain, as well as develop an interactive map of how these circuits overlap across domains. We find that some of the circuits underlying social behavior are general and are involved in the control of multiple behavioral aspects, whereas other circuits appear to be specialized for specific aspects of social behavior. Our overlapping circuit map therefore helps to delineate the circuits involved in the various domains of social behavior and to identify gaps in knowledge. Lay SummaryDifficulties with social function are a core feature of autism, and we currently lack a clear understanding of the brain circuitry underlying social behaviors. We reviewed the literature that has identified brain nodes and circuits associated with social interest, the rewarding nature of social interactions, memory for social partners, dominance, and aggression in rodents. Our review, which reveals that some nodes/circuits may be involved in the control of many aspects of social behaviors, whereas other nodes/circuits appear to specialize in the control of specific behaviors, identifies gaps in our current understanding of these circuits.

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Abnormal innate and learned behavior induced by neuron–microglia miscommunication is related to CA3 reconfiguration

Méndez-Salcido

Torres-Flores

Ordaz

et al. 2022

Glia

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Neuron-microglia communication through the Cx3cr1-Cx3cl1 axis is essential for the development and refinement of neural circuits, which determine their function into adulthood. In the present work we set out to extend the behavioral characterization of Cx3cr1 À/À mice evaluating innate behaviors and spatial navigation, both dependent on hippocampal function. Our results show that Cx3cr1-deficient mice, which show some changes in microglial and synaptic terminals morphology and density, exhibit alterations in activities of daily living and in the rapid encoding of novel spatial information that, nonetheless, improves with training. A neural substrate for these cognitive deficiencies was found in the form of synaptic dysfunction in the CA3 region of the hippocampus, with a marked impact on the mossy fiber (MF) pathway. A network analysis of the CA3 microcircuit reveals the effect of these synaptic alterations on the functional connectivity among CA3 neurons with diminished strength and topological reorganization in Cx3cr1-deficient mice. Neonatal population activity of the CA3 region in Cx3cr1-deficient mice shows a marked reorganization around the giant depolarizing potentials, the first form of network-driven activity of the hippocampus, suggesting that alterations found in adult subjects arise early on in postnatal development, a critical period of microglia-dependent neural circuit refinement. Our results show that interruption of the Cx3cr1-Cx3cl1/neuronmicroglia axis leads to changes in CA3 configuration that affect innate and learned behaviors.

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A role for CA3 in social recognition memory

Cited by 104 publications

References 60 publications

Oxytocin and vasopressin in the rodent hippocampus

Oxytocin and vasopressin in the rodent hippocampus

Circuits underlying social function and dysfunction

Abnormal innate and learned behavior induced by neuron–microglia miscommunication is related to CA3 reconfiguration

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