“…The presence of CuRE-like elements in the promoter of CaCTR1 may facilitate tight control of copper uptake by a Mac1p-like transactivator, leading to copper homeostasis. Iron availability has been shown to affect C. albicans growth, hyphal production, adherence to host cells and the ability to set up an infection in mice (Sweet & Douglas, 1991;Valenti et al, 1986;Moors et al, 1992;Fratti et al, 1998;Eck et al, 1999;Ramanan & Wang, 2000). In S. cerevisiae the dependence of iron acquisiton on the uptake and delivery of copper to Fet3p is well documented and evidence suggests that a similar system operates in C. albicans (Morrissey et al, 1996;Eck et al, 1999;Hamacott et al, 2000;Ramanan & Wang, 2000).…”