1992
DOI: 10.1084/jem.175.6.1643
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A role for complement receptor-like molecules in iron acquisition by Candida albicans.

Abstract: Candida albicans, an opportunistic fungal pathogen of humans, is dependent upon iron for growth. Consequently, human serum inhibits C. albicans growth due to the presence of high affinity iron-binding proteins that sequester serum iron, making it unavailable for use by the organism. We report that in the inhibitory environment of human serum, the growth of C. albicans can be restored by the addition of exogenous hemoglobin or heme, but not by protoporphyrin IX, the heme precursor that does not contain iron. We… Show more

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Cited by 81 publications
(69 citation statements)
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“…The presence of CuRE-like elements in the promoter of CaCTR1 may facilitate tight control of copper uptake by a Mac1p-like transactivator, leading to copper homeostasis. Iron availability has been shown to affect C. albicans growth, hyphal production, adherence to host cells and the ability to set up an infection in mice (Sweet & Douglas, 1991;Valenti et al, 1986;Moors et al, 1992;Fratti et al, 1998;Eck et al, 1999;Ramanan & Wang, 2000). In S. cerevisiae the dependence of iron acquisiton on the uptake and delivery of copper to Fet3p is well documented and evidence suggests that a similar system operates in C. albicans (Morrissey et al, 1996;Eck et al, 1999;Hamacott et al, 2000;Ramanan & Wang, 2000).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The presence of CuRE-like elements in the promoter of CaCTR1 may facilitate tight control of copper uptake by a Mac1p-like transactivator, leading to copper homeostasis. Iron availability has been shown to affect C. albicans growth, hyphal production, adherence to host cells and the ability to set up an infection in mice (Sweet & Douglas, 1991;Valenti et al, 1986;Moors et al, 1992;Fratti et al, 1998;Eck et al, 1999;Ramanan & Wang, 2000). In S. cerevisiae the dependence of iron acquisiton on the uptake and delivery of copper to Fet3p is well documented and evidence suggests that a similar system operates in C. albicans (Morrissey et al, 1996;Eck et al, 1999;Hamacott et al, 2000;Ramanan & Wang, 2000).…”
Section: Discussionmentioning
confidence: 99%
“…The organism can acquire iron from haem and can bind to and lyse erythrocytes (Manns et al, 1994;Moors et al, 1992). Although C. albicans can produce siderophores (Ismail et al, 1985;Sweet & Douglas, 1991) it is still not clear how it obtains ferrous iron from these complexes or from other sources.…”
Section: Introductionmentioning
confidence: 99%
“…6 In humans, iron is found in some proteins, including hemoglobin (a component of erythrocytes). The ability of C. albicans to utilize hemoglobin as an iron source was first described by Moors et al 7 According to their study, the first step of C. albicans infection in vivo involves binding to erythrocytes through receptors of the complement system. Next, C. albicans produces a hemolysis factor that induces lysis of the erythrocyte.…”
Section: Introductionmentioning
confidence: 99%
“…Haemolytic activity has been identified in C. albicans and the pathogen has been proposed to obtain iron by attaching to and lysing complement-coated erythrocytes (Manns et al, 1994;Moors et al, 1992). In addition, the inhibitory growth effects of transferrin on C. albicans can be reversed by the addition of haem or haemoglobin (Moors et al, 1992).…”
Section: Introductionmentioning
confidence: 99%
“…In addition, the inhibitory growth effects of transferrin on C. albicans can be reversed by the addition of haem or haemoglobin (Moors et al, 1992). Although the genes that encode the haemolysins have not yet been identified, the mechanisms involved in acquiring extracellular iron have begun to be elucidated.…”
Section: Introductionmentioning
confidence: 99%