2020
DOI: 10.1096/fasebj.2020.34.s1.03401
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A Role for Keratinocytes in Peripheral Kappa Opioid Receptor‐Mediated Antinociception

Abstract: Peripherally‐expressed kappa opioid receptors (KOR) are a promising target to treat inflammatory pain that would be devoid of CNS related adverse effects. We have found that local injectionof KOR agonists into the rat hindpaw produces a profound antinociceptive response that is mediated by activation of G protein‐coupled inwardly‐rectifying potassium (GIRK) channels. We confirmed with immunohistochemistry that both KOR and GIRK2 channels are expressed in intraepidermal nerve fibers (IENFS), which propagate noc… Show more

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