A Role for lncRNAs in Regulating Inflammatory and Autoimmune Responses Underlying Type 1 Diabetes

Brodnicki, Thomas C.

doi:10.1007/978-3-030-92034-0_6

Cited by 2 publications

(1 citation statement)

References 209 publications

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“…DNA methylation, chromatin modifications, and post-translational modifications of histones have been implicated as the main epigenetic mechanisms. Alteration in the expression pattern of Non-coding RNA sequences like microRNA (miRNA/miR) and long non-coding RNA (lncRNA) has also been shown to regulate the β cell function as well as its cellular identity [138][139][140][141][142][143][144][145][146][147][148][149][150][151].…”

Section: Epigenetic Regulation Of β Cell-specific Gene Expression Pro...mentioning

confidence: 99%

MicroRNAs and Pancreatic ß Cell Functional Modulation

Irfan¹,

Jabeen²,

Anwar³

2022

Recent Advances in Noncoding RNAs

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Recent reports of diabetes susceptibility loci located on the non-coding regions of the genome highlight the importance of epigenetic control in health and disease. Specifically, microRNAs have shown to have an important regulatory role in pancreatic ß cell physiology. Human studies implicated that ß cell mass and function are regulated by microRNAs in health and disease. Further, the microRNAs are also implicated in ensuing diabetic complications. Delineating the peculiar role of microRNAs in ß cell physiology and pathophysiology will fill the missing gaps in our current knowledge and help to devise better treatment regimens for diabetes. This chapter will discuss multiple effects of different microRNAs on the ß cell physiology in the context of maintenance and function in Type 2 diabetes mellitus.

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Section: Epigenetic Regulation Of β Cell-specific Gene Expression Pro...mentioning

confidence: 99%

MicroRNAs and Pancreatic ß Cell Functional Modulation

Irfan¹,

Jabeen²,

Anwar³

2022

Recent Advances in Noncoding RNAs

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An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes

et al. 2022

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Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. Here, we study temporal events in pancreatic islets in LEW.1WR1 rats, in which autoimmune diabetes can be induced with virus infection, by performing transcriptional analysis of islets harvested during the pre-diabetic period. Single-cell RNA-Seq and differential expression analyses of islets from pre-diabetic rats reveal subsets of β and α cells under stress as evidenced by heightened expression, over time, of a transcriptional signature characterized by interferon-stimulated genes, chemokines including Cxcl10, major histocompatibility class I, and genes for the ubiquitin-proteasome system. Mononuclear phagocytes show increased expression of inflammatory markers. RNA-in situ hybridization of rat pancreatic tissue defines the spatial distribution of Cxcl10+ β and α cells and their association with CD8+ T cell infiltration, a hallmark of insulitis and islet destruction. Our studies define early islet transcriptional events during immune cell recruitment to islets and reveal spatial associations between stressed β and α cells and immune cells. Insights into such early processes can assist in the development of therapeutic and prevention strategies for T1D.

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A Role for lncRNAs in Regulating Inflammatory and Autoimmune Responses Underlying Type 1 Diabetes

Cited by 2 publications

References 209 publications

MicroRNAs and Pancreatic ß Cell Functional Modulation

MicroRNAs and Pancreatic ß Cell Functional Modulation

An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes

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