A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

Suzuki, Hiroshi; Kurihara, Yukiko; Takeya, Motohiro; Kamada, Nobuo; Kataoka, Motoyukl; Jishage, Kou-ichi; Ueda, Otoya; Sakaguchi, Hisashl; Higashi, Takayuki; Suzuki, Takahiro; Takashima, Yohei; Kawabe, Yojiro; Cynshi, Osamu; Wada, Youichiro; Honda, Makoto; Kurihara, Hiroki; Aburatani, Hiroyuki; Doi, Takefumi; Matsumoto, Akiyo; Azuma, Sadahiro; Noda, Tetsuo; Toyoda, Yutaka; Itakura, Hiroshige; Yazaki, Yoshio; Horiuchi, Seikoh; Takahashi, Kiyoshi; Kruijt, J. Kar; Berkel, Theo J.C. Van; Steinbrecher, Urs P.; Ishibashi, Shun; Maeda, Nobuyo; Gordon, Siamon; Kodama, Tatsuhiko

doi:10.1038/386292a0

Cited by 1,112 publications

(900 citation statements)

References 27 publications

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“…Descriptions of the construct and the phenotypic expression in homozygous knock-out mice have been reported previously [24]. Normal littermates were bred as controls.…”

Section: Methodsmentioning

confidence: 99%

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

et al. 2005

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Aims/hypothesis: Glomerular mesangial expansion is a characteristic feature of diabetic nephropathy, and the accumulation of AGE in the mesangial lesion has been implicated as one of its potential causes. However, the route for the AGE accumulation in mesangial lesions in diabetic patients is poorly established. Methods: Glycolaldehyde-modified BSA (GA-BSA) and methylglyoxalmodified BSA (MG-BSA) were prepared as model AGE proteins, and their in vivo plasma clearance was examined in mice, and renal uptake by in vitro studies with isolated renal mesangial cells. Results: Both 111 In-GA-BSA and 111

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“…Descriptions of the construct and the phenotypic expression in homozygous knock-out mice have been reported previously [24]. Normal littermates were bred as controls.…”

Section: Methodsmentioning

confidence: 99%

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

et al. 2005

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“…40 Upregulation of ICAM-1 in cultured human and rabbit arterial endothelial cells has been shown to occur after lysophosphatidylcholine treatment. 41 Moreover, lysophosphatidylcholine induced the expression of ICAM-1 on endothelium derived from human iliac arteries but not from Values are meanϮSEM (n) and express ratio (%) of lesion area to media area (measured in 2 ). P values are shown for ApoE Ϫ/Ϫ (SKO) and ApoE Ϫ/Ϫ /ICAM-1 Ϫ/Ϫ (DKO) mice fed a chow or fat diet from 0 to 20 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Oxidized LDL, one of the factors thought to affect vessel wall integrity, 3 can lead to an inflammatory response. 4 Such a response will induce endothelial cell activation, extravasation of leukocytes, and migratory/reparative process by vascular smooth muscle.…”

mentioning

confidence: 99%

ICAM-1 Deficiency Reduces Atherosclerotic Lesions in Double-Knockout Mice (ApoE ⁻ ^/− /ICAM-1 ⁻ ^/− ) Fed a Fat or a Chow Diet

Bourdillon

Poston

Covacho

et al. 2000

ATVB

147

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Abstract-Intercellular adhesion molecule (ICAM)-1, a major adhesion molecule, plays a critical role in the homing of leukocytes to sites of atherosclerotic lesions. However, very little is known on the role of ICAM-1 in initiating and perpetuating vascular lesions in ApoE Ϫ/Ϫ mice fed a chow or a fat diet. This study has investigated the mean aortic lesions in mice (C57BL6 background) with a single-knockout (ApoE Ϫ/Ϫ ) or double-knockout (DKO; ApoE Ϫ/Ϫ , ICAM-1 Ϫ/Ϫ ) fed a chow or a fat diet over a period of 3, 6, 15, and 20 weeks. A 3-fold reduction in lesion size was observed at all time points in DKO mice fed a chow diet. However, in DKO mice fed a fat diet, a marked reduction in the aortic lesion was observed at 3 and 15 weeks, which did not reach a significant level at 6 and 20 weeks. This study shows in essence that DKO mice are protected from developing significant lesions for up to 6 weeks when fed a chow diet and from 3 to 6 weeks when fed a fat diet. After 6 weeks, the lesion size of the DKO mice follows that of the single-knockout mice when fed a chow diet and gets to the same level in mice fed a fat diet. Plasma cholesterol levels were not altered as a result of ICAM-1 deficiency. These studies show that ICAM-1 is implicated in the formation and progression of atherosclerotic lesions.

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“…Mice deficient in SR-A on a 129/ICR genetic background have been described (12). C3H/HeJ and C3H/HeN mice were obtained from Harlan (Oxon, U.K.).…”

Section: Animalsmentioning

confidence: 99%

The Class A Macrophage Scavenger Receptor Attenuates CXC Chemokine Production and the Early Infiltration of Neutrophils in Sterile Peritonitis

Cotena

Gordon

Platt

2004

The Journal of Immunology

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The macrophage scavenger receptor (SR-A) is a multifunctional receptor that is associated with several important pathological conditions, including atherosclerosis. In this study, we show, using a sterile peritonitis model, that it can regulate the inflammatory response. SR-A null mice display an increased initial granulocytic infiltration because of overproduction of the CXC chemokines, MIP-2 and keratinocyte-derived cytokine. This differential response is dependent upon particle internalization and can be mimicked by advanced glycation end product-BSA-conjugated latex beads. Thus SR-A is a nonactivating receptor, which is the first example of a pattern recognition receptor that serves to counter the activities of proinflammatory receptors and attenuates the production of specific chemokines to ensure an inflammatory response of the appropriate magnitude.

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A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

Cited by 1,112 publications

References 27 publications

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

ICAM-1 Deficiency Reduces Atherosclerotic Lesions in Double-Knockout Mice (ApoE ⁻ ^/− /ICAM-1 ⁻ ^/− ) Fed a Fat or a Chow Diet

The Class A Macrophage Scavenger Receptor Attenuates CXC Chemokine Production and the Early Infiltration of Neutrophils in Sterile Peritonitis

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A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

Cited by 1,112 publications

References 27 publications

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

ICAM-1 Deficiency Reduces Atherosclerotic Lesions in Double-Knockout Mice (ApoE − /− /ICAM-1 − /− ) Fed a Fat or a Chow Diet

The Class A Macrophage Scavenger Receptor Attenuates CXC Chemokine Production and the Early Infiltration of Neutrophils in Sterile Peritonitis

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ICAM-1 Deficiency Reduces Atherosclerotic Lesions in Double-Knockout Mice (ApoE ⁻ ^/− /ICAM-1 ⁻ ^/− ) Fed a Fat or a Chow Diet