A role for P-selectin in neutrophil and platelet infiltration in immune complex glomerulonephritis.

Zachem, Charles; Alpers, Charles E.; Way, William; Shankland, Stuart J.; Couser, William G.; Johnson, Richard J.

doi:10.1681/asn.v8121838

Cited by 31 publications

(2 citation statements)

References 26 publications

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“… 1 Accordingly, PLAs are well established markers of immune-thrombosis and have been shown to be elevated in a variety of thrombo-inflammatory conditions. 27 , 28 , 29 PLA levels have been shown to be higher in COVID-19 patients and correlate with disease severity. 20 , 21 , 22 , 23 In addition, platelet-monocyte interaction was shown to result in higher tissue factor (TF) expression by monocytes.…”

Section: Discussionmentioning

confidence: 99%

Circulating cellular clusters are associated with thrombotic complications and clinical outcomes in COVID-19

Dorken-Gallastegi¹,

Lee²,

Li³

et al. 2023

iScience

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Section: Discussionmentioning

confidence: 99%

Circulating cellular clusters are associated with thrombotic complications and clinical outcomes in COVID-19

Dorken-Gallastegi¹,

Lee²,

Li³

et al. 2023

iScience

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“…Участие тромбоцитов в этих процессах опосредовано их непосредственным взаимодействием с лейкоцитами, о чем свидетельствуют результаты экспериментов. Отсутствие или блокирование тромбоцитарного P-селектина значительно снижало инфильтрацию нейтрофилов и вызванное этим нарушение функции почек в моделях экспериментального гломерулонефрита [73,147] и постишемической почечной недостаточности [119]. В клубочковых капиллярах происходит постоянное динамическое взаимодействие тромбоцитов с моноцитами и нейтрофилами, а при воспалении количество и длительность таких взаимодействий значительно возрастает, причем мобилизация и активация нейтрофилов происходит только в присутствии тромбоцитов [37].…”

Section: тромбоцитарно-лейкоцитарные взаимодействияunclassified

Platelet-leukocyte interactions: immunoregulatory role and pathophysiological relevance

et al. 2022

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Blood platelets are the central players in thrombosis and blood coagulation. Moreover, they also exhibit immunoregulatory properties and bridge hemostasis and immunity. Morphological and functional characteristics of the platelets ensure continuous surveillance for the vascular system, recognition of different hazards, development of appropriate response and recruitment of immune cells. Indirect platelet-leukocyte interactions are mediated by immunoregulatory molecules that are released, along with coagulation and thrombosis factors in the course of platelet activation and degranulation. Chemokines, cytokines, growth factors, some of which are synthesized de novo, are released from activated platelets and modulate cellular functions, thus modulating both innate and adaptive immune response. Activated platelets enter contacts with immune cells to form heterotypic aggregates, i.e., platelet-leukocyte complexes that reside in blood circulation along with other blood cells. The aggregate formation and stabilization is mediated by interaction between the molecules expressed on the surface of platelets and leukocytes, in particular, P-selectin (CD62P) and PSGL-1 (CD162). Platelet-monocyte and platelet-neutrophil complexes are most abundant, with platelet-monocyte aggregates being most stable. Moreover, the platelet-derived microvesicles also interact with leukocytes to form heterotypic aggregates, thus, probably, modulating the immune cell functions via transfer of non-coding RNA molecules. Formation of platelet-leukocyte complexes results into mutual activation of platelets and leukocytes. Platelets and platelet-derived microvesicles stimulate phagocytic activity, cytokine secretion, and generation of reactive oxygen species in monocytes and neutrophils, inducing formation of neutrophilic extracellular traps and procoagulant phenotype in monocytes. The blood platelets regulate monocyte differentiation, promote adhesion, as well as transmigration of lymphocytes and NK cells. At the sites of inflammation, platelets enhance extravasation and infiltration of leukocytes into the damaged tissue. Impaired interactions of platelets with endothelial layer and immune cells may underlie pathogenic conditions. Increased level of circulating plateletleukocyte complexes is observed in various disorders including cardiovascular diseases, acute ischemic stroke, respiratory disorders, renal pathologies, liver diseases, diabetes, reproductive disorders, bacterial and viral infections. Further studies of platelet-leukocyte interactions are warranted to unveil pathogenic mechanisms and to develop new therapeutic approaches.

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Therapeutic effect of sulphated hyaluronic acid, a potential selectin‐blocking agent, on experimental progressive mesangial proliferative glomerulonephritis

Matsuda

Shikata

Shimizu

et al. 2002

The Journal of Pathology

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The initial event in the process of leukocyte infiltration is characterized by leukocyte rolling on the surface of the endothelium, which is mediated by selectins. P- and L-selectin bind to the sulphated sugar chains of their natural ligands, including sulphated glycolipids such as sulphatide. Recently, it has been demonstrated that sulphated glycolipids and sulphated oligosaccharides interfere with selectin binding pathways. This study synthesized sulphated hyaluronic acid (SHA), which is a potential selectin-blocking agent, and examined its therapeutic effect on the experimental progressive mesangial proliferative glomerulonephritis induced by anti-Thy-1 monoclonal antibody (1-22-3 MAb) after unilateral nephrectomy. The selectin-inhibitory effect of SHA in vitro was confirmed. SHA inhibited the binding of P- and L-selectin to sulphatide, which is a glycolipid ligand for P- and L-selectin, at a concentration of 1.5 micro g/ml and 100 micro g/ml. Immunohistochemical examination showed that P-selectin was up-regulated in the glomeruli in the 1-22-3 MAb nephritis model, while the ligands for L-selectin were not detected in the glomerular tufts. A single administration of SHA ameliorated proteinuria and glomerular leukocyte infiltration in 24 h after the injection of anti-Thy-1 MAb. Anti-P-selectin MAb, but not anti-L-selectin MAb, inhibited proteinuria and glomerular leukocyte infiltration. To examine further the therapeutic effect of SHA on chronic glomerulonephritis, SHA was administered daily from day 3 to day 14 in this model. Proteinuria and glomerular leukocyte infiltration were significantly diminished in SHA-treated rats on day 14. These results suggest that SHA ameliorated rat progressive mesangial proliferative glomerulonephritis by inhibiting P-selectin-dependent leukocyte infiltration in glomeruli. Sulphated oligosaccharides may be beneficial for the therapy of mesangial proliferative glomerulonephritis.

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A role for P-selectin in neutrophil and platelet infiltration in immune complex glomerulonephritis.

Cited by 31 publications

References 26 publications

Circulating cellular clusters are associated with thrombotic complications and clinical outcomes in COVID-19

Circulating cellular clusters are associated with thrombotic complications and clinical outcomes in COVID-19

Platelet-leukocyte interactions: immunoregulatory role and pathophysiological relevance

Therapeutic effect of sulphated hyaluronic acid, a potential selectin‐blocking agent, on experimental progressive mesangial proliferative glomerulonephritis

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