A role for tetracycline selection in the evolution of Clostridium difficile PCR-ribotype 078

Abstract

Consequently, an unusually high proportion of RT078 genomes were tetM positive (76.5%). 35Additional tetracycline resistance determinants were also identified, some for the first time in

Levofloxacin Prophylaxis During Induction Therapy for Pediatric Acute Lymphoblastic Leukemia

“…Therefore, using fluoroquinolone prophylaxis to reduce exposure to other antibiotics might prevent C. difficile infection, but this is the first study to show such a benefit. Previous studies of quinolone prophylaxis in adults showed no such effect on C. difficile infection [6], and some studies have even identified fluoroquinolone exposure as a risk factor for C. difficile infection [35]. The difference in the current study may be related to the marked reduction in the use of broad-spectrum antibiotic therapy or to predominance of quinolone-susceptible C. difficile [2,35].…”

Clostridium difficile ribotype 017 – characterization, evolution and epidemiology of the dominant strain in Asia

“…Besides these antimicrobials, C. difficile RT 017 also has higher rates of resistance to tetracyclines and rifaximin [107–109]. Tetracycline resistance was associated with an outbreak of C. difficile RT 078 [110,111]. Rifaximin is a derivative of rifampicin which was also associated with the outbreak of C. difficile RT 027 [112,113].…”

A global to local genomics analysis of Clostridioides difficile ST1/RT027 identifies cryptic transmission events in a northern Arizona healthcare network

“…Use of tetracyclines has not been frequently linked to CDI [113]; however, tetracycline resistance has been associated with some lineages of C. difficile such as RT078 (ST11) [114–116]. No strains were fully resistant to vancomycin, which is a recommended treatment option for CDI [42], despite the presence of CDSs associated with vancomycin resistance being detected in one tested genome.…”