A role for the hepatobiliary system in IgE‐mediated intestinal inflammation in the rat

Collins, '; Leach,; Mitchell, Payne A.; Dai, Ming; Jackson, Rod

doi:10.1046/j.1365-2222.1999.00425.x

Cited by 12 publications

(14 citation statements)

References 25 publications

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“…There are at least two types of mast cells, the mucosal type of mast cells (MMC) and the connective tissuetype of mast cells. In rats, staining of mast cells in liver sections with alcian blue/safranin indicates that these cells are predominantly of the mucosal subtype [18], with Collins and co-workers reporting that <7% of hepatic mast cells had the staining characteristics of connective tissue mast cells [20]. These MMC are the local source of large quantities of chemical mediators, including histamine [12,13], leukotrienes [21], and plateletactivating factor [22], which have been postulated to play important functions in the pathogenesis of I/Rinduced tissue injury.…”

Section: Discussionmentioning

confidence: 92%

Mast Cells Are Not Involved in the Ischemia-Reperfusion Injury in Perfused Rat Liver

Shibamoto

Tsutsumi

Kuda

et al. 2012

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 92%

Mast Cells Are Not Involved in the Ischemia-Reperfusion Injury in Perfused Rat Liver

Shibamoto

Tsutsumi

Kuda

et al. 2012

Journal of Surgical Research

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“…Not unreasonably, mast cells of the gastrointestinal tract have been implicated as the major effector cells in such reactions, 4 , 5 being ideally located at the site of inflammation and tissue damage. However, recent evidence suggests that the hepatobiliary system plays a crucial role in IgE‐mediated gastrointestinal hypersensitivity 6 . Although both hepatic and extrahepatic mast cells could account for the inflammatory mediators that have been detected in bile, the possible involvement of hepatic mast cells (HMC) highlights the need to better understand the nature and phenotype of these rarely studied cells.…”

Section: Introductionmentioning

confidence: 99%

Mast cells in the rat liver are phenotypically heterogeneous and exhibit features of immaturity

2001

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Summary Gastrointestinal hypersensitivity to food allergens is a significant but relatively poorly understood allergic disease. Recent evidence from a rat model of IgE-mediated gastrointestinal hypersensitivity has suggested that hepatic mast cells (HMC) may play an important role in such reactions. The present study was undertaken to better define their phenotype. Livers from Australian albino Wistar (AaW), Brown Norway (BN) and PVG/c rats were examined using traditional histological techniques and reverse transcription-polymerase chain reaction (RT-PCR). Hepatic mast cells were overwhelmingly Alcian blue positive, sensitive to formalin fixation and predominantly rat mast cell protease (RMCP) 1 + /2 -(AaW 57%; BN 53%). Such a phenotype has previously been associated with an immature mast cell phenotype. A significant number of HMC also stained RMCP 1 -/2 + (AaW 15%; BN 19%) or were RMCP 1 + /2 + (AaW 24%; BN 26%). In contrast to previous reports, RT-PCR showed that the liver expressed mRNA of other mast cell proteases, including the chymase RMCP 5 as well as two tryptases, RMCP 6 and RMCP 7. These results suggest that HMC are a heterogeneous population of mast cells with some characteristics previously associated with immature cells.

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“…showed that DBA/2 mice fed a continuous casein diet produced high level of casein‐specific IgE accompanied by an increase in Th2 cells in the liver 60 . Furthermore, mast cells that require IL‐4 for their survival and play an important role in IgE‐mediated hypersensitivity develop in the liver after feeding an Ag 61 . More importantly, a report has described a case in which a peanut allergy was transferred to the recipient of a donor liver, but not to the recipient of the kidney and pancreas of the same donor 62 .…”

Section: Portal Vein Tolerance and Food Allergymentioning

confidence: 99%

Molecular mechanisms of portal vein tolerance

Watanabe

Kudo

Chiba³

et al. 2007

Hepatology Research

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The liver has been considered as a tolerogenic organ in the sense that favors the induction of peripheral tolerance. The administration of antigens (Ags) via the portal vein causes tolerance, which is termed portal vein tolerance and can explain the occurrence of tolerogenic responses in the liver. Here we discuss the fundamental mechanisms accounting for portal vein tolerance. Antigen-presenting cells (APCs) in the liver, especially dendritic cells and sinusoidal endothelial cells, have limited the ability to produce pro-inflammatory cytokines upon stimulation with endotoxin, an effect that could be due to the continuous exposure to bacterial Ags derived from intestinal microflora. Ag presentation by liver APCs results in T cell tolerance through clonal deletion and selection of regulatory T cells. Thus, APCs with immunosuppressive functions are associated with the achievement of portal vein tolerance via the induction of clonal deletion and generation of regulatory T cells.

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A role for the hepatobiliary system in IgE‐mediated intestinal inflammation in the rat

Abstract: The data indicate that biliary products are major contributors to the gastrointestinal damage arising from IgE-mediated hypersensitivity reactions in the rat, and such hypersensitivity reactions may involve a population of mast cells which reside in the liver.

Cited by 12 publications

References 25 publications

Mast Cells Are Not Involved in the Ischemia-Reperfusion Injury in Perfused Rat Liver

Mast Cells Are Not Involved in the Ischemia-Reperfusion Injury in Perfused Rat Liver

Mast cells in the rat liver are phenotypically heterogeneous and exhibit features of immaturity

Molecular mechanisms of portal vein tolerance

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